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Protein

Short transient receptor potential channel 5

Gene

TRPC5

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.

Enzyme regulationi

Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 5
Short name:
Rtrp5
Short name:
TrpC5
Alternative name(s):
Capacitative calcium entry channel 2
Short name:
CCE2
Gene namesi
Name:TRPC5
Synonyms:TRP5
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 330CytoplasmicSequence analysisAdd BLAST330
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 398ExtracellularSequence analysisAdd BLAST47
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 437CytoplasmicSequence analysisAdd BLAST18
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 470ExtracellularSequence analysisAdd BLAST12
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Topological domaini492 – 512CytoplasmicSequence analysisAdd BLAST21
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 603ExtracellularSequence analysisAdd BLAST70
Transmembranei604 – 624HelicalSequence analysisAdd BLAST21
Topological domaini625 – 974CytoplasmicSequence analysisAdd BLAST350

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153201 – 974Short transient receptor potential channel 5Add BLAST974

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi461N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Interactioni

Subunit structurei

Homotetramer and heterotetramer with TRPC1 and/or TRPC4. Interacts with NHERF. Interacts with MX1 and RNF24. Interacts (via C-terminus) with CABP1. Interacts with SESTD1 (via the spectrin 1 repeat). Interacts with TRPC4AP.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007983.

Structurei

3D structure databases

ProteinModelPortaliO62852.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 60ANK 1Add BLAST30
Repeati69 – 97ANK 2Add BLAST29
Repeati98 – 124ANK 3Add BLAST27
Repeati141 – 170ANK 4Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni972 – 974Essential for binding to NHERF PDZ domainBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi690 – 693Poly-Arg4

Sequence similaritiesi

Contains 4 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiO62852.
KOiK04968.
OMAiNCSKSEI.
OrthoDBiEOG091G029I.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005461. TRPC5_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF24. PTHR10117:SF24. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01646. TRPCHANNEL5.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequencei

Sequence statusi: Complete.

O62852-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLNAV EKGDYATVKQ
60 70 80 90 100
ALQEAEIYYN VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL
110 120 130 140 150
LYAIRKEVVG AVELLLSYRK PSGEKQVPTL MMDTQFSEFT PDITPIMLAA
160 170 180 190 200
HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE CVSSSEVDSL RHSRSRLNIY
210 220 230 240 250
KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE YEELSQQCKL
260 270 280 290 300
FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE
310 320 330 340 350
FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI
360 370 380 390 400
SPRSNLGLFI KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP
410 420 430 440 450
TVVEWMILPW VLGFIWGEIK EMWDGGFTEY IHDWWNLMDF AMNSLYLATI
460 470 480 490 500
SLKIVAYVKY NGSRPREEWE MWHPTLIAEA LFAISNILSS LRLISLFTAN
510 520 530 540 550
SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF YYETRAIDEP
560 570 580 590 600
NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV
610 620 630 640 650
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY
660 670 680 690 700
FDEGGTLPPP FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRHNLRSFT
710 720 730 740 750
ERHADSLIQN QHYQEVIRNL VKRYVAAMIR NSKTNEGLTE ENFKELKQDI
760 770 780 790 800
SSFRYEVLDL LGNRKQPRRS LSTSSTELSQ RDDTNDGSGG ARAKSKSVSF
810 820 830 840 850
NLGCKKKACH GPPLIRTMPR ASGAQGKSKA ESSSKRSFMG PSLKKLGLLF
860 870 880 890 900
SKFNGHMSEP SSEPMYTISD GIVQQHYMWQ DIRYSQMEKG KAEACSQSEI
910 920 930 940 950
NLSEVELGEV RGAAQSSECP LTCSSSLHCA SSICSSNSKL LDSSEDVFET
960 970
WGEACDLLMH KWGDGQEEQV TTRL
Length:974
Mass (Da):111,537
Last modified:August 1, 1998 - v1
Checksum:i94256E0F2B925316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006203 mRNA. Translation: CAA06911.1.
RefSeqiNP_001076248.1. NM_001082779.1.
UniGeneiOcu.3063.

Genome annotation databases

EnsembliENSOCUT00000009246; ENSOCUP00000007983; ENSOCUG00000009245.
GeneIDi100009574.
KEGGiocu:100009574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006203 mRNA. Translation: CAA06911.1.
RefSeqiNP_001076248.1. NM_001082779.1.
UniGeneiOcu.3063.

3D structure databases

ProteinModelPortaliO62852.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007983.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000009246; ENSOCUP00000007983; ENSOCUG00000009245.
GeneIDi100009574.
KEGGiocu:100009574.

Organism-specific databases

CTDi7224.

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiO62852.
KOiK04968.
OMAiNCSKSEI.
OrthoDBiEOG091G029I.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005461. TRPC5_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF24. PTHR10117:SF24. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01646. TRPCHANNEL5.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC5_RABIT
AccessioniPrimary (citable) accession number: O62852
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.