O62846 (KAPCG_MACMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
cAMP-dependent protein kinase catalytic subunit gamma
Short name=PKA C-gamma
EC=2.7.11.11

Gene names

Name:

PRKACG

Organism

Macaca mulatta (Rhesus macaque)

Taxonomic identifier

9544 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	209 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Activated by cAMP.
Subunit structure	A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
Tissue specificity	Testis specific.
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding cAMP
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Lipoprotein Myristate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cAMP-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – ›209	›208	cAMP-dependent protein kinase catalytic subunit gamma		PRO_0000086065
Regions
	Domain	43 – ›209	›167	Protein kinase
	Nucleotide binding	49 – 57	9	ATP By similarity
Sites
	Active site	166	1	Proton acceptor By similarity
	Binding site	72	1	ATP By similarity
Amino acid modifications
	Modified residue	197	1	Phosphothreonine; by autocatalysis By similarity
	Lipidation	2	1	N-myristoyl glycine By similarity
Experimental info
	Non-terminal residue	209	1

Sequences

	Sequence		Length	Mass (Da)
	O62846 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 9BAEB8B1363DD1A4	FASTA	209	24,096
	10 20 30 40 50 60 MGNAAAKKDT EQETVNEFLA KARGDFLYRW GNPAQNTASS DQFERLKTLG TGSYGRVMLV 70 80 90 100 110 120 RHRETGNHYA MKILDKQKVV RLKQVEHTLN EKRILQAINF PFLVKLQFSF KDNSNLYLVM 130 140 150 160 170 180 EYVPGGEMFS HLRRVGRFSE PQACFYAAQV VLAFQYLHSL DLIHRDLKPE NLLIDQQGYL 190 200 QVTDFGFAKR VKGRTWTLCG TPEYLAPEI

References

[1]	"The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon." Reinton N., Haugen T.B., Orstavik S., Skalhegg B.S., Hansson V., Jahnsen T., Tasken K. Genomics 49:290-297(1998) [PubMed: 9598317] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ001927 Genomic DNA. Translation: CAA05098.1.
3D structure databases
ProteinModelPortal	O62846.
SMR	O62846. Positions 4-209.
ModBase	Search...
Protein-protein interaction databases
STRING	O62846.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	prNOG19322.
GeneTree	ENSGT00550000074358.
HOVERGEN	HBG108317.
InParanoid	O62846.
OrthoDB	EOG4J118D.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAPCG_MACMU

Accession

Primary (citable) accession number: O62846

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 23, 2007
Last modified:	September 21, 2011
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program