O62839 (CATA_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catalase
EC=1.11.1.6

Gene names

Name:

CAT

Organism

Sus scrofa (Pig) [Complete proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.
Catalytic activity	2 H2O2 = O2 + 2 H2O.
Cofactor	Heme group By similarity. NADP By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the catalase family.
Sequence caution	The sequence BAA25301.1 differs from that shown. Reason: Frameshift at position 504.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Peroxisome
Ligand	Heme Iron Metal-binding NADP
Molecular function	Mitogen Oxidoreductase Peroxidase
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	catalase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 527	526	Catalase		PRO_0000084903
Sites
	Active site	75	1	By similarity
	Active site	148	1	By similarity
	Metal binding	358	1	Iron (heme axial ligand) By similarity
Amino acid modifications
	Modified residue	231	1	Phosphotyrosine By similarity
	Modified residue	308	1	Phosphotyrosine By similarity
	Modified residue	517	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O62839 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 20BC72D91893FFE9	FASTA	527	59,883
	10 20 30 40 50 60 MADNRDPASD QMKHWKEQRA AQKPDILTTG SGNPIGDKLN ILTAGPRGPL LVQDVVFTDE 70 80 90 100 110 120 MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRFSKAKVF EHVGKRTPIA VRFSTVAGES 130 140 150 160 170 180 GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDAIL FPSFIHSQKR NPQTHLKDPD 190 200 210 220 230 240 MVWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNEKGEAV YCKFHYKTDQ 250 260 270 280 290 300 GIKNLSVEDA ARLPQEDPDY GIRDLFNAIA TGNYPSWTFY IQVMTFQEAE AFPFNPFDLT 310 320 330 340 350 360 KVWPHSEYPL IPVGKLVLNR NPVNYFAEVE QMAFDPSNMP PGIEPSPDKM LQGRLFGYPD 370 380 390 400 410 420 THRHRLGANY LQIPVNCPFR ARVANYQRDG PMCFQDNQGG APNYYPNSFS APEQTHSALE 430 440 450 460 470 480 HCTRYSGDVQ RFNSANEDNV TQVRTFYLNV LNEEERKRLC ENIAGHLKDA QLFIQKKAVK 490 500 510 520 NFSDVHPDYG ARIQALLDKY NAEXPENAVH TYVQAGSHLA AREKANL

References

[1]	"Swine catalase deduced from cDNA and localization of the catalase gene on swine chromosome 2p16-p15." Lin Z.-H., Wang Y.-F., Sarai A., Yasue H. Biochem. Genet. 35:297-302(1997) [PubMed: 9475954] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Landrace. Tissue: Liver.
[2]	"Porcine submaxillary gland GDP-L-fucose: beta-D-galactoside alpha-2-L-fucosyltransferase is likely a counterpart of the human Secretor gene-encoded blood group transferase." Thurin J., Blaszczyk-Thurin M. J. Biol. Chem. 270:26577-26580(1995) [PubMed: 7592879] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-38 AND 321-349. Tissue: Submandibular gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D89812 mRNA. Translation: BAA25301.1. Frameshift.
RefSeq	NP_999466.2. NM_214301.2.
UniGene	Ssc.1018.
3D structure databases
ProteinModelPortal	O62839.
SMR	O62839. Positions 4-501.
ModBase	Search...
Protein-protein interaction databases
STRING	O62839.
Protein family/group databases
PeroxiBase	5272. SscKat01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397568.
KEGG	ssc:397568.
Organism-specific databases
CTD	847.
Phylogenomic databases
GeneTree	ENSGT00390000018100.
HOVERGEN	HBG003986.
OrthoDB	EOG45TCMV.
Family and domain databases
InterPro	IPR018028. Catalase. IPR020835. Catalase-like_dom. IPR024708. Catalase_AS. IPR024711. Catalase_clade1/3. IPR011614. Catalase_core. IPR002226. Catalase_haem_BS. IPR010582. Catalase_immune_responsive. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
KO	K03781.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. PF06628. Catalase-rel. 1 hit. [Graphical view]
PIRSF	PIRSF038928. Catalase_clade1-3. 1 hit.
PRINTS	PR00067. CATALASE.
SMART	SM01060. Catalase. 1 hit. [Graphical view]
SUPFAM	SSF56634. Catalase_N. 1 hit.
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA_PIG

Accession

Primary (citable) accession number: O62839
Secondary accession number(s): Q9TR38, Q9TR39

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 81 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program