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Reviewed, UniProtKB/Swiss-Prot O62839 (CATA_PIG)

Last modified October 13, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Catalase
    EC=1.11.1.6
Gene names
Name: CAT
OrganismSus scrofa (Pig)
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

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Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.

Catalytic activity

2 H2O2 = O2 + 2 H2O.

Cofactor

Heme group By similarity.

NADP By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the catalase family.

Sequence caution

The sequence BAA25301.1 differs from that shown. Reason: Frameshift at position 504.

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Ontologies

Keywords
   Biological processHydrogen peroxide
   Cellular componentPeroxisome
   LigandHeme
Iron
Metal-binding
NADP
   Molecular functionMitogen
Oxidoreductase
Peroxidase
   PTMPhosphoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processhydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncatalase activity

Inferred from electronic annotation. Source: EC

heme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 527526Catalase
PRO_0000084903

Sites

Active site751 By similarity
Active site1481 By similarity
Metal binding3581Iron (heme axial ligand) By similarity

Amino acid modifications

Modified residue2311Phosphotyrosine By similarity
Modified residue3081Phosphotyrosine By similarity
Modified residue5171Phosphoserine By similarity

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Sequences

Sequence LengthMass (Da)Tools
O62839-1 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 20BC72D91893FFE9

FASTA52759,883
        10         20         30         40         50         60 
MADNRDPASD QMKHWKEQRA AQKPDILTTG SGNPIGDKLN ILTAGPRGPL LVQDVVFTDE 

        70         80         90        100        110        120 
MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRFSKAKVF EHVGKRTPIA VRFSTVAGES 

       130        140        150        160        170        180 
GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDAIL FPSFIHSQKR NPQTHLKDPD 

       190        200        210        220        230        240 
MVWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNEKGEAV YCKFHYKTDQ 

       250        260        270        280        290        300 
GIKNLSVEDA ARLPQEDPDY GIRDLFNAIA TGNYPSWTFY IQVMTFQEAE AFPFNPFDLT 

       310        320        330        340        350        360 
KVWPHSEYPL IPVGKLVLNR NPVNYFAEVE QMAFDPSNMP PGIEPSPDKM LQGRLFGYPD 

       370        380        390        400        410        420 
THRHRLGANY LQIPVNCPFR ARVANYQRDG PMCFQDNQGG APNYYPNSFS APEQTHSALE 

       430        440        450        460        470        480 
HCTRYSGDVQ RFNSANEDNV TQVRTFYLNV LNEEERKRLC ENIAGHLKDA QLFIQKKAVK 

       490        500        510        520 
NFSDVHPDYG ARIQALLDKY NAEXPENAVH TYVQAGSHLA AREKANL

« Hide

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References

[1]"Swine catalase deduced from cDNA and localization of the catalase gene on swine chromosome 2p16-p15."
Lin Z.-H., Wang Y.-F., Sarai A., Yasue H.
Biochem. Genet. 35:297-302(1997) [PubMed: 9475954] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Landrace.
Tissue: Liver.
[2]"Porcine submaxillary gland GDP-L-fucose: beta-D-galactoside alpha-2-L-fucosyltransferase is likely a counterpart of the human Secretor gene-encoded blood group transferase."
Thurin J., Blaszczyk-Thurin M.
J. Biol. Chem. 270:26577-26580(1995) [PubMed: 7592879] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-38 AND 321-349.
Tissue: Submandibular gland.

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Cross-references

Sequence databases

D89812 mRNA. Translation: BAA25301.1. Frameshift.
RefSeqNP_999466.1.
UniGeneSsc.1018

3D structure databases

HSSPHSSP built from PDB template 4BLC based on UniProtKB P00432.
SMRO62839. Positions 5-501.
ModBaseSearch...

Protein family/group databases

PeroxiBase5272. SscKat01.

Genome annotation databases

GeneID397568.
KEGGssc:397568.

Organism-specific databases

CTD397568.

Phylogenomic databases

HOVERGENO62839.

Enzyme and pathway databases

BRENDA1.11.1.6. 249.

Family and domain databases

InterProIPR002226. Catalase.
IPR010582. Catalase-rel_immune_responsive.
IPR011614. Catalase_N.
IPR018028. Catalase_rel_subgroup.
[Graphical view]
Gene3DG3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHERPTHR11465. Catalase. 1 hit.
PfamPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PRINTSPR00067. CATALASE.
ProDomPD000510. Catalase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCATA_PIG
AccessionPrimary (citable) accession number: O62839
Secondary accession number(s): Q9TR38, Q9TR39
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: October 13, 2009
This is version 66 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents