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O62830 (PPM1B_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein phosphatase 1B
EC=3.1.3.16
Alternative name(s):
Protein phosphatase 2C isoform beta
Short name=PP2C-beta
Gene names
Name:PPM1B
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Enzyme with a broad specificity.

Catalytic activity

A phosphoprotein + H2O = a protein + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the PP2C family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Beta-1 (identifier: O62830-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta-2 (identifier: O62830-2)

The sequence of this isoform differs from the canonical sequence as follows:
     359-364: NIIFFR → K
     384-392: ASDEAEESG → GAGDLEDPW
     393-484: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 484484Protein phosphatase 1B
PRO_0000057745

Sites

Metal binding601Manganese 1 By similarity
Metal binding601Manganese 2 By similarity
Metal binding611Manganese 1; via carbonyl oxygen By similarity
Metal binding2431Manganese 2 By similarity
Metal binding2861Manganese 2 By similarity

Natural variations

Alternative sequence359 – 3646NIIFFR → K in isoform Beta-2.
VSP_020009
Alternative sequence384 – 3929ASDEAEESG → GAGDLEDPW in isoform Beta-2.
VSP_020010
Alternative sequence393 – 48492Missing in isoform Beta-2.
VSP_020011

Sequences

Sequence LengthMass (Da)Tools
Isoform Beta-1 [UniParc].

Last modified July 25, 2006. Version 2.
Checksum: 453DD1E6E7D47D27

FASTA48453,431
        10         20         30         40         50         60 
MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL EDWSFFAVYD 

        70         80         90        100        110        120 
GHAGSRVANY CSTHLLEHIT NNEDFRAAGK SGSALEPSVE NVKNGIRTGF LKIDEYMRNF 

       130        140        150        160        170        180 
SDLRNGMDRS GSTAVGVMIS PKHIYFINCG DSRAVLYRSG QVCFSTQDHK PCNPREKERI 

       190        200        210        220        230        240 
QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL 

       250        260        270        280        290        300 
ACDGIWDVMS NEELCEFVKS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSI VLVCFSNAPK 

       310        320        330        340        350        360 
VSDEAMRKDS ELDKYLESRV EEIMEKSGEE GMPDLAHVMR ILSAENIPNL PPGGGLAGNI 

       370        380        390        400        410        420 
IFFRRHVIEA VYSRLNPHRE SDGASDEAEE SGSQGKLVEA LRQMRINHRG NYRQLLEEML 

       430        440        450        460        470        480 
TSYRLAKVEG EENPAEQAAT AASSNSDAGN TVAMQESHTE SKSDLAELDS CTEDAGTKMS 


GEKL

« Hide

Isoform Beta-2 [UniParc].

Checksum: D70B95141250FFB1
Show »

FASTA38742,834

References

« Hide 'large scale' references
[1]"Protein phosphatase type-2C isozymes present in vertebrate retinae: purification, characterization, and localization in photoreceptors."
Klumpp S., Selke D., Fischer D., Baumann A., Mueller F., Thanos S.
J. Neurosci. Res. 51:328-338(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-2).
Tissue: Retina.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-1).
Strain: Crossbred X Angus.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ005458 mRNA. Translation: CAA06555.1.
BC111235 mRNA. Translation: AAI11236.1.
IPIIPI00691012.
IPI00782896.
RefSeqNP_776855.1. NM_174430.2.
UniGeneBt.5004.

3D structure databases

ProteinModelPortalO62830.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000043518.

Proteomic databases

PRIDEO62830.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000046197; ENSBTAP00000043518; ENSBTAG00000000223.
ENSBTAT00000050064; ENSBTAP00000046832; ENSBTAG00000000223.
GeneID281995.
KEGGbta:281995.

Organism-specific databases

CTD5495.

Phylogenomic databases

eggNOGCOG0631.
GeneTreeENSGT00650000093052.
HOGENOMHOG000233895.
HOVERGENHBG053647.
InParanoidO62830.
KOK04461.
OMAVMISPEH.
OrthoDBEOG4BP1BZ.

Family and domain databases

Gene3D1.10.10.430. 1 hit.
3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like.
IPR012911. PP2C_C.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
PF07830. PP2C_C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. PP2C-related. 1 hit.
SSF81601. PP2C_C. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805863.

Entry information

Entry namePPM1B_BOVIN
AccessionPrimary (citable) accession number: O62830
Secondary accession number(s): Q2T9W5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 25, 2006
Last modified: April 3, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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