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Protein

ADM

Gene

ADM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hypotensive peptide. May function as a hormone in circulation control (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-BTA-418555. G alpha (s) signalling events.
R-BTA-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
ADM
Cleaved into the following 3 chains:
Adrenomedullin
Short name:
AM
Adrenomedullin-11-26
Short name:
AM 11-26
Alternative name(s):
ProAM N-terminal 20 peptide
Short name:
PAMP
Short name:
ProAM-N20
Gene namesi
Name:ADM
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PeptideiPRO_000000095322 – 41Proadrenomedullin N-20 terminal peptideBy similarityAdd BLAST20
PropeptideiPRO_000000095445 – 92By similarityAdd BLAST48
PeptideiPRO_000000095595 – 146AdrenomedullinBy similarityAdd BLAST52
PeptideiPRO_0000246182105 – 120Adrenomedullin-11-261 PublicationAdd BLAST16
PropeptideiPRO_0000000956153 – 188PreproAM C-terminal fragmentBy similarityAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Arginine amideBy similarity1
Disulfide bondi110 ↔ 115By similarity
Modified residuei146Tyrosine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiO62827.

Expressioni

Gene expression databases

BgeeiENSBTAG00000021048.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028036.

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4C. Eukaryota.
ENOG41120TV. LUCA.
GeneTreeiENSGT00390000000451.
HOGENOMiHOG000033821.
HOVERGENiHBG004181.
InParanoidiO62827.
KOiK12333.
OMAiVAPRNKI.
OrthoDBiEOG091G0QFI.
TreeFamiTF333447.

Family and domain databases

InterProiIPR001710. Adrenomedullin.
IPR021116. Calcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00801. ADRENOMEDULN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O62827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVPVALLY LGSLAFLGVD TARLDVAAEF RKKWNKWALS RGKRELRESS
60 70 80 90 100
SYPTGLADVK AGPVQTLIRP QDVKGASRSP QASSPDAARI RVKRYRQSLN
110 120 130 140 150
NFQGLRSFGC RFGTCTVQKL AHQIYHFTDK DKDGSAPRSK ISPQGYGRRR
160 170 180
RRSLPEAGLG RTLLQPPEPK LRGAPDSRVH QVLATLRI
Length:188
Mass (Da):20,963
Last modified:July 25, 2006 - v2
Checksum:i6102E69A756DCA86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9L → M in CAA04866 (PubMed:9585168).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001613 mRNA. Translation: CAA04866.1.
AB055107 mRNA. Translation: BAB62176.1.
BC123826 mRNA. Translation: AAI23827.1.
RefSeqiNP_776313.1. NM_173888.3.
XP_005215950.1. XM_005215893.3.
XP_005215951.1. XM_005215894.3.
XP_015330126.1. XM_015474640.1.
UniGeneiBt.2047.

Genome annotation databases

EnsembliENSBTAT00000028036; ENSBTAP00000028036; ENSBTAG00000021048.
ENSBTAT00000063482; ENSBTAP00000053999; ENSBTAG00000021048.
GeneIDi280713.
KEGGibta:280713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001613 mRNA. Translation: CAA04866.1.
AB055107 mRNA. Translation: BAB62176.1.
BC123826 mRNA. Translation: AAI23827.1.
RefSeqiNP_776313.1. NM_173888.3.
XP_005215950.1. XM_005215893.3.
XP_005215951.1. XM_005215894.3.
XP_015330126.1. XM_015474640.1.
UniGeneiBt.2047.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028036.

Proteomic databases

PaxDbiO62827.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028036; ENSBTAP00000028036; ENSBTAG00000021048.
ENSBTAT00000063482; ENSBTAP00000053999; ENSBTAG00000021048.
GeneIDi280713.
KEGGibta:280713.

Organism-specific databases

CTDi133.

Phylogenomic databases

eggNOGiENOG410IK4C. Eukaryota.
ENOG41120TV. LUCA.
GeneTreeiENSGT00390000000451.
HOGENOMiHOG000033821.
HOVERGENiHBG004181.
InParanoidiO62827.
KOiK12333.
OMAiVAPRNKI.
OrthoDBiEOG091G0QFI.
TreeFamiTF333447.

Enzyme and pathway databases

ReactomeiR-BTA-418555. G alpha (s) signalling events.
R-BTA-419812. Calcitonin-like ligand receptors.

Gene expression databases

BgeeiENSBTAG00000021048.

Family and domain databases

InterProiIPR001710. Adrenomedullin.
IPR021116. Calcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00801. ADRENOMEDULN.
ProtoNetiSearch...

Entry informationi

Entry nameiADML_BOVIN
AccessioniPrimary (citable) accession number: O62827
Secondary accession number(s): Q08DC5, Q95KP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 25, 2006
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.