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Protein

Short transient receptor potential channel 2 homolog

Gene

TRPC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to form a receptor-activated calcium permeant cation channel.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 2 homolog
Short name:
TrpC2
Alternative name(s):
Transient receptor protein 2
Short name:
TRP-2
Short name:
bTrp2
Gene namesi
Name:TRPC2
Synonyms:TRP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Short transient receptor potential channel 2 homologPRO_0000215309Add
BLAST

Proteomic databases

PRIDEiO62826.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015344.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257288.
InParanoidiO62826.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01643. TRPCHANNEL2.

Sequencei

Sequence statusi: Complete.

O62826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVILSLYLAA FTLRLLLAGL AHKHCRDAPD GAACHYFTSA ERSEWRTEDP
60 70 80 90 100
QFLAEVLFAV TSMLSFTRLA SILPAHESLG TLQISMGRMI DDMIRFMFIL
110 120 130 140 150
MIILTAFLCG LNNIYVPYQE TERLGNFNET FQFLFWTMFG MEEHSVVDMP
160 170 180 190 200
QFLVPEFVGR ALYGIFTIVM VIVLLNMLIA MITNSFQKIE DAADVEWKFA
210 220 230 240 250
RSKLYLSYFR EGLTLPVPFN ILPSPKAIFY LLRRVFRFIC CCHFCCKTKK
260 270 280 290 300
PDYPPIPTFA NPGAGAGPGE GERGSYRLRV IKALVQRYIE TAQREFEETR
310 320 330 340 350
RKDLGNRLTE LTKTVSRLQS EVAGVQRAVV EAGPRRPPGG ASVLSRYITR
360 370 380 390 400
VRNSFQNLGP PIPETPELTV PATVGTQESS EIGLPDAGGA QAPASGESGP
410 420 430
SSPAHVLVHR EQESEGAGDL PQEADLGAKE GT
Length:432
Mass (Da):48,057
Last modified:August 1, 1998 - v1
Checksum:i9BA438C22E98B02C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006304 mRNA. Translation: CAA06964.1.
UniGeneiBt.2872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006304 mRNA. Translation: CAA06964.1.
UniGeneiBt.2872.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015344.

Proteomic databases

PRIDEiO62826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG257288.
InParanoidiO62826.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01643. TRPCHANNEL2.
ProtoNetiSearch...

Publicationsi

  1. "Structure and mRNA expression of a bovine trp homologue related to mammalian trp2 transcripts."
    Wissenbach U., Schroth G., Philipp S., Flockerzi V.
    FEBS Lett. 429:61-66(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiTRPC2_BOVIN
AccessioniPrimary (citable) accession number: O62826
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.