O62826 (TRPC2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Short transient receptor potential channel 2 homolog
Short name=TrpC2

Alternative name(s):
Transient receptor protein 2
Short name=TRP-2
Short name=bTrp2

Gene names

Name:	TRPC2
Synonyms:	TRP2

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Thought to form a receptor-activated calcium permeant cation channel By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC2 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	Short transient receptor potential channel 2 homolog		PRO_0000215309
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	52 – 72	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	162 – 182	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O62826 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 9BA438C22E98B02C	FASTA	432	48,057
	10 20 30 40 50 60 MVILSLYLAA FTLRLLLAGL AHKHCRDAPD GAACHYFTSA ERSEWRTEDP QFLAEVLFAV 70 80 90 100 110 120 TSMLSFTRLA SILPAHESLG TLQISMGRMI DDMIRFMFIL MIILTAFLCG LNNIYVPYQE 130 140 150 160 170 180 TERLGNFNET FQFLFWTMFG MEEHSVVDMP QFLVPEFVGR ALYGIFTIVM VIVLLNMLIA 190 200 210 220 230 240 MITNSFQKIE DAADVEWKFA RSKLYLSYFR EGLTLPVPFN ILPSPKAIFY LLRRVFRFIC 250 260 270 280 290 300 CCHFCCKTKK PDYPPIPTFA NPGAGAGPGE GERGSYRLRV IKALVQRYIE TAQREFEETR 310 320 330 340 350 360 RKDLGNRLTE LTKTVSRLQS EVAGVQRAVV EAGPRRPPGG ASVLSRYITR VRNSFQNLGP 370 380 390 400 410 420 PIPETPELTV PATVGTQESS EIGLPDAGGA QAPASGESGP SSPAHVLVHR EQESEGAGDL 430 PQEADLGAKE GT

References

[1]	"Structure and mRNA expression of a bovine trp homologue related to mammalian trp2 transcripts." Wissenbach U., Schroth G., Philipp S., Flockerzi V. FEBS Lett. 429:61-66(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ006304 mRNA. Translation: CAA06964.1.
IPI	IPI00685255.
UniGene	Bt.2872.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000015344.
Proteomic databases
PRIDE	O62826.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG257288.
Family and domain databases
InterPro	IPR005821. Ion_trans_dom. IPR005458. TRPC2_channel. IPR002153. TRPC_channel. [Graphical view]
PANTHER	PTHR10117. PTHR10117. 1 hit. PTHR10117:SF6. PTHR10117:SF6. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. [Graphical view]
PRINTS	PR01097. TRNSRECEPTRP. PR01643. TRPCHANNEL2.
ProtoNet	Search...

Entry information

Entry name

TRPC2_BOVIN

Accession

Primary (citable) accession number: O62826

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	August 1, 1998
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program