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O62826 (TRPC2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Short transient receptor potential channel 2 homolog

Short name=TrpC2
Alternative name(s):
Transient receptor protein 2
Short name=TRP-2
Short name=bTrp2
Gene names
Name:TRPC2
Synonyms:TRP2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Thought to form a receptor-activated calcium permeant cation channel By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC2 sub-subfamily. [View classification]

Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandCalcium
   Molecular functionCalcium channel
Ion channel
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncalcium channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Short transient receptor potential channel 2 homolog
PRO_0000215309

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane52 – 7221Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane162 – 18221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O62826 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 9BA438C22E98B02C

FASTA43248,057
        10         20         30         40         50         60 
MVILSLYLAA FTLRLLLAGL AHKHCRDAPD GAACHYFTSA ERSEWRTEDP QFLAEVLFAV 

        70         80         90        100        110        120 
TSMLSFTRLA SILPAHESLG TLQISMGRMI DDMIRFMFIL MIILTAFLCG LNNIYVPYQE 

       130        140        150        160        170        180 
TERLGNFNET FQFLFWTMFG MEEHSVVDMP QFLVPEFVGR ALYGIFTIVM VIVLLNMLIA 

       190        200        210        220        230        240 
MITNSFQKIE DAADVEWKFA RSKLYLSYFR EGLTLPVPFN ILPSPKAIFY LLRRVFRFIC 

       250        260        270        280        290        300 
CCHFCCKTKK PDYPPIPTFA NPGAGAGPGE GERGSYRLRV IKALVQRYIE TAQREFEETR 

       310        320        330        340        350        360 
RKDLGNRLTE LTKTVSRLQS EVAGVQRAVV EAGPRRPPGG ASVLSRYITR VRNSFQNLGP 

       370        380        390        400        410        420 
PIPETPELTV PATVGTQESS EIGLPDAGGA QAPASGESGP SSPAHVLVHR EQESEGAGDL 

       430 
PQEADLGAKE GT 

« Hide

References

[1]"Structure and mRNA expression of a bovine trp homologue related to mammalian trp2 transcripts."
Wissenbach U., Schroth G., Philipp S., Flockerzi V.
FEBS Lett. 429:61-66(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ006304 mRNA. Translation: CAA06964.1.
UniGeneBt.2872.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000015344.

Proteomic databases

PRIDEO62826.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG257288.

Family and domain databases

InterProIPR005821. Ion_trans_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR01097. TRNSRECEPTRP.
PR01643. TRPCHANNEL2.
ProtoNetSearch...

Entry information

Entry nameTRPC2_BOVIN
AccessionPrimary (citable) accession number: O62826
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: August 1, 1998
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families