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Protein

Promotilin

Gene

MLN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.By similarity

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Promotilin
Cleaved into the following 2 chains:
Gene namesi
Name:MLN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525By similarityAdd
BLAST
Chaini26 – 11590PromotilinPRO_0000342167Add
BLAST
Peptidei26 – 4722MotilinPRO_0000019176Add
BLAST
Peptidei50 – 11566Motilin-associated peptidePRO_0000019177Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiO62820.
PRIDEiO62820.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020661.

Family & Domainsi

Sequence similaritiesi

Belongs to the motilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J17F. Eukaryota.
ENOG411197B. LUCA.
HOGENOMiHOG000108883.
HOVERGENiHBG003618.
InParanoidiO62820.
KOiK05265.

Family and domain databases

InterProiIPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR015662. Promotilin.
[Graphical view]
PANTHERiPTHR14156. PTHR14156. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O62820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRKATAVL LAVHAAAMLA SQTEAFVPIF TYGEVRRMQE KERYKGQKKS
60 70 80 90 100
LSVQQRSEEV GPVDPTEPWE EKQEVIKLTA PVEIGMRMNS RQLEKYQATL
110
EGLLREVLPP SRNAQ
Length:115
Mass (Da):13,055
Last modified:August 1, 1998 - v1
Checksum:i017DDB70EEA5EE68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068196 mRNA. Translation: AAC18864.1.
RefSeqiNP_776363.1. NM_173938.2.
UniGeneiBt.35.

Genome annotation databases

GeneIDi280860.
KEGGibta:280860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068196 mRNA. Translation: AAC18864.1.
RefSeqiNP_776363.1. NM_173938.2.
UniGeneiBt.35.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020661.

Proteomic databases

PaxDbiO62820.
PRIDEiO62820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280860.
KEGGibta:280860.

Organism-specific databases

CTDi4295.

Phylogenomic databases

eggNOGiENOG410J17F. Eukaryota.
ENOG411197B. LUCA.
HOGENOMiHOG000108883.
HOVERGENiHBG003618.
InParanoidiO62820.
KOiK05265.

Miscellaneous databases

NextBioi20805004.

Family and domain databases

InterProiIPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR015662. Promotilin.
[Graphical view]
PANTHERiPTHR14156. PTHR14156. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence and characterization of cDNA encoding the motilin precursor from chicken, dog, cow and horse. Evidence of mosaic evolution in prepromotilin."
    Huang Z., Depoortere I., De Clercq P., Peeters T.
    Gene 240:217-226(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Duodenal mucosa.

Entry informationi

Entry nameiMOTI_BOVIN
AccessioniPrimary (citable) accession number: O62820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.