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Protein

Promotilin

Gene

MLN

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.By similarity

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Promotilin
Cleaved into the following 2 chains:
Gene namesi
Name:MLN
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000034216726 – 115PromotilinAdd BLAST90
PeptideiPRO_000001917626 – 47MotilinAdd BLAST22
PeptideiPRO_000001917750 – 115Motilin-associated peptideAdd BLAST66

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiO62820.
PRIDEiO62820.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020661.

Family & Domainsi

Sequence similaritiesi

Belongs to the motilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J17F. Eukaryota.
ENOG411197B. LUCA.
HOGENOMiHOG000108883.
HOVERGENiHBG003618.
InParanoidiO62820.
KOiK05265.

Family and domain databases

InterProiIPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR015662. Promotilin.
[Graphical view]
PANTHERiPTHR14156. PTHR14156. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O62820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRKATAVL LAVHAAAMLA SQTEAFVPIF TYGEVRRMQE KERYKGQKKS
60 70 80 90 100
LSVQQRSEEV GPVDPTEPWE EKQEVIKLTA PVEIGMRMNS RQLEKYQATL
110
EGLLREVLPP SRNAQ
Length:115
Mass (Da):13,055
Last modified:August 1, 1998 - v1
Checksum:i017DDB70EEA5EE68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068196 mRNA. Translation: AAC18864.1.
RefSeqiNP_776363.1. NM_173938.2.
UniGeneiBt.35.

Genome annotation databases

GeneIDi280860.
KEGGibta:280860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068196 mRNA. Translation: AAC18864.1.
RefSeqiNP_776363.1. NM_173938.2.
UniGeneiBt.35.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020661.

Proteomic databases

PaxDbiO62820.
PRIDEiO62820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280860.
KEGGibta:280860.

Organism-specific databases

CTDi4295.

Phylogenomic databases

eggNOGiENOG410J17F. Eukaryota.
ENOG411197B. LUCA.
HOGENOMiHOG000108883.
HOVERGENiHBG003618.
InParanoidiO62820.
KOiK05265.

Family and domain databases

InterProiIPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR015662. Promotilin.
[Graphical view]
PANTHERiPTHR14156. PTHR14156. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOTI_BOVIN
AccessioniPrimary (citable) accession number: O62820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.