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Protein

Orexin receptor type 2

Gene

HCRTR2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca2+ levels in response to orexin-A binding.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei44 – 441Important for responses to orexinBy similarity
Binding sitei324 – 3241AgonistBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-SSC-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-SSC-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin receptor type 2
Short name:
Ox-2-R
Short name:
Ox2-R
Short name:
Ox2R
Alternative name(s):
Hypocretin receptor type 2
Gene namesi
Name:HCRTR2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componentsi: Chromosome 7, Unplaced

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454ExtracellularBy similarityAdd
BLAST
Transmembranei55 – 7521Helical; Name=1By similarityAdd
BLAST
Topological domaini76 – 8813CytoplasmicBy similarityAdd
BLAST
Transmembranei89 – 11022Helical; Name=2By similarityAdd
BLAST
Topological domaini111 – 12717ExtracellularBy similarityAdd
BLAST
Transmembranei128 – 15023Helical; Name=3By similarityAdd
BLAST
Topological domaini151 – 17020CytoplasmicBy similarityAdd
BLAST
Transmembranei171 – 19121Helical; Name=4By similarityAdd
BLAST
Topological domaini192 – 22231ExtracellularBy similarityAdd
BLAST
Transmembranei223 – 24321Helical; Name=5By similarityAdd
BLAST
Topological domaini244 – 30461CytoplasmicBy similarityAdd
BLAST
Transmembranei305 – 32622Helical; Name=6By similarityAdd
BLAST
Topological domaini327 – 34216ExtracellularBy similarityAdd
BLAST
Transmembranei343 – 36624Helical; Name=7By similarityAdd
BLAST
Topological domaini367 – 44478CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Orexin receptor type 2PRO_0000069991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence analysis
Disulfide bondi127 ↔ 210PROSITE-ProRule annotation
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO62809.

Structurei

3D structure databases

ProteinModelPortaliO62809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 4917Required for response to orexin-ABy similarityAdd
BLAST

Domaini

The N-terminal region is required for orexin signaling.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiO62809.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01064. OREXINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTKLEDSP PCRNWSSAPE LNETQEPFLN PTDYDDEEFL RYLWREYLHP
60 70 80 90 100
KEYEWVLIAG YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD
110 120 130 140 150
VLVTITCLPA TLVVDITETW FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL
160 170 180 190 200
DRWYAICHPL MFKSTAKRAR NSIVIIWIVS CIIMIPQAIV MECSTMLPGL
210 220 230 240 250
ANKTTLFTVC DERWGGEIYP KMYHICFFLV TYMAPLCLMV LAYLQIFRKL
260 270 280 290 300
WCRQIPGTSS VVQRKWKPLQ PVSQPRGPGQ QTKSRISAVA AEIKQIRARR
310 320 330 340 350
KTARMLMVVL LVFAICYLPI SILNVLKRVF GMFTHTEDRE TVYAWFTFSH
360 370 380 390 400
WLVYANSAAN PIIYNFLSGK FREEFKAAFS CCCLGVHHRQ EDRLARGRTS
410 420 430 440
TESRKSLTTQ ISNFDNISKL SEQVLLTSMS TLPAANGAGQ LQNW
Length:444
Mass (Da):50,765
Last modified:September 7, 2016 - v2
Checksum:i29C05AC3EBA9201A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811C → Y in AAC16044 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ321702 mRNA. Translation: ABC59144.1.
CU694214 Genomic DNA. No translation available.
AF059740 mRNA. Translation: AAC16044.1.
UniGeneiSsc.16128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ321702 mRNA. Translation: ABC59144.1.
CU694214 Genomic DNA. No translation available.
AF059740 mRNA. Translation: AAC16044.1.
UniGeneiSsc.16128.

3D structure databases

ProteinModelPortaliO62809.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO62809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiO62809.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-SSC-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-SSC-416476. G alpha (q) signalling events.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01064. OREXINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOX2R_PIG
AccessioniPrimary (citable) accession number: O62809
Secondary accession number(s): Q2MK76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 7, 2016
Last modified: September 7, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.