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Protein

Orexin receptor type 2

Gene

HCRTR2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca2+ levels in response to orexin-A binding.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei44Important for responses to orexinBy similarity1
Binding sitei324AgonistBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-SSC-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-SSC-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin receptor type 2
Short name:
Ox-2-R
Short name:
Ox2-R
Short name:
Ox2R
Alternative name(s):
Hypocretin receptor type 2
Gene namesi
Name:HCRTR2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 7

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54ExtracellularBy similarityAdd BLAST54
Transmembranei55 – 75Helical; Name=1By similarityAdd BLAST21
Topological domaini76 – 88CytoplasmicBy similarityAdd BLAST13
Transmembranei89 – 110Helical; Name=2By similarityAdd BLAST22
Topological domaini111 – 127ExtracellularBy similarityAdd BLAST17
Transmembranei128 – 150Helical; Name=3By similarityAdd BLAST23
Topological domaini151 – 170CytoplasmicBy similarityAdd BLAST20
Transmembranei171 – 191Helical; Name=4By similarityAdd BLAST21
Topological domaini192 – 222ExtracellularBy similarityAdd BLAST31
Transmembranei223 – 243Helical; Name=5By similarityAdd BLAST21
Topological domaini244 – 304CytoplasmicBy similarityAdd BLAST61
Transmembranei305 – 326Helical; Name=6By similarityAdd BLAST22
Topological domaini327 – 342ExtracellularBy similarityAdd BLAST16
Transmembranei343 – 366Helical; Name=7By similarityAdd BLAST24
Topological domaini367 – 444CytoplasmicBy similarityAdd BLAST78

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699911 – 444Orexin receptor type 2Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Glycosylationi22N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi127 ↔ 210PROSITE-ProRule annotation
Glycosylationi202N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO62809.

Structurei

3D structure databases

ProteinModelPortaliO62809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 49Required for response to orexin-ABy similarityAdd BLAST17

Domaini

The N-terminal region is required for orexin signaling.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiO62809.
KOiK04239.
OrthoDBiEOG090B07P6.
TreeFamiTF315303.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004060. Orexin_rcpt_2.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PF03827. Orexin_rec2. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01522. OREXIN2R.
PR01064. OREXINR.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O62809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTKLEDSP PCRNWSSAPE LNETQEPFLN PTDYDDEEFL RYLWREYLHP
60 70 80 90 100
KEYEWVLIAG YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD
110 120 130 140 150
VLVTITCLPA TLVVDITETW FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL
160 170 180 190 200
DRWYAICHPL MFKSTAKRAR NSIVIIWIVS CIIMIPQAIV MECSTMLPGL
210 220 230 240 250
ANKTTLFTVC DERWGGEIYP KMYHICFFLV TYMAPLCLMV LAYLQIFRKL
260 270 280 290 300
WCRQIPGTSS VVQRKWKPLQ PVSQPRGPGQ QTKSRISAVA AEIKQIRARR
310 320 330 340 350
KTARMLMVVL LVFAICYLPI SILNVLKRVF GMFTHTEDRE TVYAWFTFSH
360 370 380 390 400
WLVYANSAAN PIIYNFLSGK FREEFKAAFS CCCLGVHHRQ EDRLARGRTS
410 420 430 440
TESRKSLTTQ ISNFDNISKL SEQVLLTSMS TLPAANGAGQ LQNW
Length:444
Mass (Da):50,765
Last modified:September 7, 2016 - v2
Checksum:i29C05AC3EBA9201A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181C → Y in AAC16044 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ321702 mRNA. Translation: ABC59144.1.
CU694214 Genomic DNA. No translation available.
AF059740 mRNA. Translation: AAC16044.1.
RefSeqiNP_001123423.1. NM_001129951.1.
XP_013833190.1. XM_013977736.1.
UniGeneiSsc.16128.

Genome annotation databases

EnsembliENSSSCT00000001653; ENSSSCP00000001611; ENSSSCG00000001481.
GeneIDi397428.
KEGGissc:397428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ321702 mRNA. Translation: ABC59144.1.
CU694214 Genomic DNA. No translation available.
AF059740 mRNA. Translation: AAC16044.1.
RefSeqiNP_001123423.1. NM_001129951.1.
XP_013833190.1. XM_013977736.1.
UniGeneiSsc.16128.

3D structure databases

ProteinModelPortaliO62809.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO62809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000001653; ENSSSCP00000001611; ENSSSCG00000001481.
GeneIDi397428.
KEGGissc:397428.

Organism-specific databases

CTDi3062.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiO62809.
KOiK04239.
OrthoDBiEOG090B07P6.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-SSC-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-SSC-416476. G alpha (q) signalling events.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004060. Orexin_rcpt_2.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PF03827. Orexin_rec2. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01522. OREXIN2R.
PR01064. OREXINR.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOX2R_PIG
AccessioniPrimary (citable) accession number: O62809
Secondary accession number(s): Q2MK76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 7, 2016
Last modified: February 15, 2017
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.