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O62772 (CRFR1_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Corticotropin-releasing factor receptor 1
Short name=CRF-R-1
Short name=CRF-R1
Short name=CRFR-1
Alternative name(s):
Corticotropin-releasing hormone receptor 1
Short name=CRH-R-1
Short name=CRH-R1
Gene names
Name:CRHR1
OrganismOvis aries (Sheep)
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subunit structure

Interacts (via N-terminal extracellular domain) with CRF and UCN By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

C-terminal Ser or Thr residues may be phosphorylated.

Phosphorylation at Ser-301 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 415392Corticotropin-releasing factor receptor 1
PRO_0000012817

Regions

Topological domain24 – 12198Extracellular Potential
Transmembrane122 – 14221Helical; Name=1; Potential
Topological domain143 – 1519Cytoplasmic Potential
Transmembrane152 – 17120Helical; Name=2; Potential
Topological domain172 – 18918Extracellular Potential
Transmembrane190 – 21324Helical; Name=3; Potential
Topological domain214 – 22714Cytoplasmic Potential
Transmembrane228 – 24922Helical; Name=4; Potential
Topological domain250 – 26819Extracellular Potential
Transmembrane269 – 29123Helical; Name=5; Potential
Topological domain292 – 31423Cytoplasmic Potential
Transmembrane315 – 33420Helical; Name=6; Potential
Topological domain335 – 34915Extracellular Potential
Transmembrane350 – 36920Helical; Name=7; Potential
Topological domain370 – 41546Cytoplasmic Potential

Amino acid modifications

Modified residue3011Phosphoserine; by PKA By similarity
Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation781N-linked (GlcNAc...) Potential
Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation981N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 54 By similarity
Disulfide bond44 ↔ 87 By similarity
Disulfide bond68 ↔ 102 By similarity

Sequences

Sequence LengthMass (Da)Tools
O62772 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: FA5F652D12B4CDC4

FASTA41547,559
        10         20         30         40         50         60 
MGRRPQLRLV KALLLLGLNS ISASLQDQHC ESLSLASNVS GLQCNASVDL NGTCWPQSPA 

        70         80         90        100        110        120 
GQLVVRPCLV FFYGVRYNTT SNGYRVCLAN GTWAARVNHS ECQEILSEGE KSKAHYHIAV 

       130        140        150        160        170        180 
IINYLGHCIS LAALLVAFVL FLRLRSIRCV RNIIHWNLIS AFILRNATWF VVQLTMSPEV 

       190        200        210        220        230        240 
HQSNVGWCRL VTAAYNYFHV TNFFWMFGEG CYLHTAVVLT YSTDRLRKWM FICIGWGVPF 

       250        260        270        280        290        300 
PIIVAWAIGK LYYDNEKCWF GKRPGVYTDY IYQGPMILVL LINFIFLFNI VRILMTKLRA 

       310        320        330        340        350        360 
STTSETIQYR KAVKATLVLL PLLGITYMLF FVNPGEDEVS RVVFIYFNSF LESFQGFFVS 

       370        380        390        400        410 
VFYCFLNSEV RSAIRKRWHR WQDKHSIRAR VARAMSIPTS PTRVSFHSIK QSTAV

« Hide

References

[1]"Structure and function of the ovine type 1 corticotropin releasing factor receptor (CRF1) and a carboxyl-terminal variant."
Myers D.A., Trinh J.V., Myers T.R.
Mol. Cell. Endocrinol. 144:21-35(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF054582 mRNA. Translation: AAC08027.1.
RefSeqNP_001009727.1. NM_001009727.1.
UniGeneOar.759.

3D structure databases

ProteinModelPortalO62772.
SMRO62772. Positions 44-106.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID443025.

Organism-specific databases

CTD1394.

Phylogenomic databases

HOVERGENHBG106921.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR003052. GPCR_2_CRF1_rcpt.
IPR003051. GPCR_2_CRF_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR01279. CRFRECEPTOR.
PR01280. CRFRECEPTOR1.
PR00249. GPCRSECRETIN.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. False negative.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCRFR1_SHEEP
AccessionPrimary (citable) accession number: O62772
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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