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O62760

- CHLE_FELCA

UniProt

O62760 - CHLE_FELCA

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Protein

Cholinesterase

Gene
BCHE
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters By similarity.

Catalytic activityi

An acylcholine + H2O = choline + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei226 – 2261Acyl-ester intermediate By similarity
Active sitei353 – 3531Charge relay system By similarity
Active sitei466 – 4661Charge relay system By similarity

GO - Molecular functioni

  1. acetylcholinesterase activity Source: UniProtKB
  2. cholinesterase activity Source: UniProtKB

GO - Biological processi

  1. metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

MEROPSiS09.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholinesterase (EC:3.1.1.8)
Alternative name(s):
Acylcholine acylhydrolase
Butyrylcholine esterase
Choline esterase II
Pseudocholinesterase
Gene namesi
Name:BCHE
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Chromosome C2

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. extracellular region Source: UniProtKB-SubCell
  3. nuclear envelope lumen Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed predictionAdd
BLAST
Chaini29 – 602574CholinesterasePRO_0000008612Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi85 – 851N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi93 ↔ 120 By similarity
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Modified residuei226 – 2261Phosphoserine By similarity
Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi280 ↔ 291 By similarity
Glycosylationi284 – 2841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi369 – 3691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi428 ↔ 547 By similarity
Glycosylationi483 – 4831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi509 – 5091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi513 – 5131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi514 – 5141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi599 – 599Interchain By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Homotetramer; disulfide-linked. Dimer of dimers By similarity.

Structurei

3D structure databases

ProteinModelPortaliO62760.
SMRiO62760. Positions 32-562, 564-593.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni144 – 1452Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00740000115241.
HOVERGENiHBG008839.
KOiK01050.
OMAiWIPTPKP.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF08674. AChE_tetra. 1 hit.
PF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
ProDomiPD415333. AChE_tetra. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O62760-1 [UniParc]FASTAAdd to Basket

« Hide

MQSKGTIISI QFLLRFLLLW VLIGKSHTEE DIIITTKNGK VRGMNLPVLD    50
GTVTAFLGIP YAQPPLGRLR FKKPQFLTKW SDIWNATKYA NSCYQNADQS 100
FPGFPGSEMW NPNTDLSEDC LYLNVWIPTP KPKNATVMIW IYGGGFQTGT 150
SSLPVYDGKF LARVERVIVV SMNYRVGALG FLALPGNPEV PGNMGLFDQQ 200
LALQWVQKNI AAFGGNPKSV TLFGESAGAG SVSLHLLSPR SQPLFTRAIL 250
QSGSSNAPWA VMSLDEAKNR TLTLAKFIGC SKENDTEIIK CLRNKDPQEI 300
LLNELLVVPS DTLLSVNFGP VVDGDFLTDM PDTLLQLGQF KKTQILVGVN 350
KDEGTAFLVY GAPGFSKDND SIITRKEFQE GLKIYFPGVS EFGREAILFY 400
YVDLLDDQRA EKYREALDDV LGDYNIICPA LEFTTKFSEL GNNAFFYYFE 450
HRSSQLPWPE WMGVMHGYEI EFVFGLPLER RVNYTRAEEI LSRSIMNYWA 500
NFAKYGNPNG TQNNSTRWPA FRSTDQKYLT LNAESPKVYT KLRAQQCRFW 550
TLFFPKVLEM TGNIDEAERE WRAGFYRWNN YMMDWKNQFN DYTSKKESCA 600
GL 602
Length:602
Mass (Da):68,328
Last modified:August 1, 1998 - v1
Checksum:iECB8879232B74B9C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053483 mRNA. Translation: AAC06261.1.
RefSeqiNP_001009364.1. NM_001009364.1.

Genome annotation databases

EnsembliENSFCAT00000026436; ENSFCAP00000016618; ENSFCAG00000030105.
GeneIDi493960.
KEGGifca:493960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053483 mRNA. Translation: AAC06261.1 .
RefSeqi NP_001009364.1. NM_001009364.1.

3D structure databases

ProteinModelPortali O62760.
SMRi O62760. Positions 32-562, 564-593.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.980.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSFCAT00000026436 ; ENSFCAP00000016618 ; ENSFCAG00000030105 .
GeneIDi 493960.
KEGGi fca:493960.

Organism-specific databases

CTDi 590.

Phylogenomic databases

GeneTreei ENSGT00740000115241.
HOVERGENi HBG008839.
KOi K01050.
OMAi WIPTPKP.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR014788. AChE_tetra.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view ]
Pfami PF08674. AChE_tetra. 1 hit.
PF00135. COesterase. 1 hit.
[Graphical view ]
PRINTSi PR00878. CHOLNESTRASE.
ProDomi PD415333. AChE_tetra. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma."
    Bartels C.F., Xie W., Miller-Lindholm A.K., Schopfer L.M., Lockridge O.
    Biochem. Pharmacol. 60:479-487(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiCHLE_FELCA
AccessioniPrimary (citable) accession number: O62760
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: August 1, 1998
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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