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Protein

Non-specific lipid-transfer protein

Gene

SCP2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis (By similarity).By similarity1 Publication

Catalytic activityi

3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl-CoA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific lipid-transfer protein (EC:2.3.1.176)
Short name:
NSL-TP
Alternative name(s):
Propanoyl-CoA C-acyltransferase
SCP-chi
SCPX
Sterol carrier protein 2
Short name:
SCP-2
Sterol carrier protein X
Short name:
SCP-X
Gene namesi
Name:SCP2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Mitochondrion By similarity

  • Note: Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues.By similarity
Isoform SCPx :
  • Peroxisome By similarity

  • Note: Interaction with PEX5 is essential for peroxisomal import.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000340951 – 547Non-specific lipid-transfer proteinAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineBy similarity1
Modified residuei7N6-acetyllysineBy similarity1
Modified residuei40N6-succinyllysineBy similarity1
Modified residuei132N6-acetyllysine; alternateBy similarity1
Modified residuei132N6-succinyllysine; alternateBy similarity1
Modified residuei168N6-succinyllysineBy similarity1
Modified residuei173N6-acetyllysineBy similarity1
Modified residuei177N6-acetyllysineBy similarity1
Modified residuei183N6-acetyllysine; alternateBy similarity1
Modified residuei183N6-succinyllysine; alternateBy similarity1
Modified residuei282N6-succinyllysineBy similarity1
Modified residuei341N6-acetyllysine; alternateBy similarity1
Modified residuei341N6-succinyllysine; alternateBy similarity1
Modified residuei432N6-acetyllysine; alternateBy similarity1
Modified residuei432N6-succinyllysine; alternateBy similarity1
Modified residuei438N6-acetyllysine; alternateBy similarity1
Modified residuei438N6-succinyllysine; alternateBy similarity1
Modified residuei443N6-acetyllysine; alternateBy similarity1
Modified residuei443N6-succinyllysine; alternateBy similarity1
Modified residuei453N6-acetyllysine; alternateBy similarity1
Modified residuei453N6-succinyllysine; alternateBy similarity1
Modified residuei464N6-succinyllysineBy similarity1
Modified residuei470N6-acetyllysine; alternateBy similarity1
Modified residuei470N6-succinyllysine; alternateBy similarity1
Modified residuei479N6-succinyllysineBy similarity1
Modified residuei491N6-acetyllysineBy similarity1
Modified residuei492N6-succinyllysineBy similarity1
Modified residuei511N6-succinyllysineBy similarity1
Modified residuei516PhosphoserineBy similarity1
Modified residuei522N6-succinyllysineBy similarity1
Modified residuei534N6-succinyllysineBy similarity1
Modified residuei544N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiO62742.

Interactioni

Subunit structurei

Interacts with PEX5.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000019823.

Structurei

Secondary structure

1547
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi432 – 454Combined sources23
Beta strandi457 – 465Combined sources9
Helixi467 – 469Combined sources3
Beta strandi472 – 480Combined sources9
Beta strandi484 – 487Combined sources4
Beta strandi494 – 500Combined sources7
Helixi501 – 508Combined sources8
Helixi514 – 519Combined sources6
Beta strandi524 – 527Combined sources4
Helixi529 – 536Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C44X-ray1.80A425-547[»]
ProteinModelPortaliO62742.
SMRiO62742.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO62742.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini433 – 543SCP2Add BLAST111

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi545 – 547Microbody targeting signalSequence analysis3

Sequence similaritiesi

In the N-terminal section; belongs to the thiolase family.Curated
Contains 1 SCP2 domain.Curated

Phylogenomic databases

eggNOGiKOG1406. Eukaryota.
KOG4170. Eukaryota.
ENOG410XPRW. LUCA.
HOGENOMiHOG000221741.
HOVERGENiHBG006506.
InParanoidiO62742.
KOiK08764.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
3.40.47.10. 4 hits.
InterProiIPR003033. SCP2_sterol-bd_dom.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02036. SCP2. 1 hit.
PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
SSF55718. SSF55718. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform SCPx (identifier: O62742-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSARKLAP LPRVFVVGVG MTKFVKPGTE DARDYPDMAK EAGQKALADA
60 70 80 90 100
QIPYSAVEQA CIGYVYGDST CGQRAVYHSL GLTGIPIINV NNNCSTGSTA
110 120 130 140 150
LFMGRQLIQG GMAECVLALG FEKMERGSLG AKFPDRTNPM DKHLDVLINK
160 170 180 190 200
YGLSAHPVAP QMFGSAGKEH MEKYGTKIEH FAKIGWKNHK HSVNNPYSQF
210 220 230 240 250
QKEYSLDEVM SSRPIFDFLT VLQCCPTSDG AAAAILASEE FVKKYGLQSK
260 270 280 290 300
AVEILAQEMV TDFPSSFEEK SIIKMVGFDM SKEAARRCYE KSGLRPSDID
310 320 330 340 350
VIELHDCFSA NELLTYEALG LCPEGKGGAL VDRGDNTYGG KWVINPSGGL
360 370 380 390 400
ISKGHPLGAT GLAQCAELCW QLRGEAGKRQ VPGAKVALQH NLGLGGAAVV
410 420 430 440 450
TLYKMGFPEA ASSFRTHQIE AAPTSSAGDG FKANLVFKEI EKKLEEEGEQ
460 470 480 490 500
FVKKIGGIFA FKVKDGPGGK EATWVVDVKN GKGSVLPNSD KKADCTITIA
510 520 530 540
DSDLLALMTG KMNPQSAFFQ GKLKITGNMG LAMKLQNLQL QPGKAKL
Length:547
Mass (Da):58,904
Last modified:August 1, 1998 - v1
Checksum:i32BE7F7DCBF9BCD7
GO
Isoform SCP2 (identifier: O62742-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-404: Missing.

Note: Mitochondrial precursor. Contains a mitochondrial transit peptide at positions 1-20 (Potential).Curated
Show »
Length:143
Mass (Da):15,305
Checksum:i8970B49A3B9E2928
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188961 – 404Missing in isoform SCP2. 1 PublicationAdd BLAST404

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051897 mRNA. Translation: AAC15422.1.
RefSeqiNP_001075504.1. NM_001082035.1. [O62742-1]
UniGeneiOcu.2203.

Genome annotation databases

GeneIDi100008683.
KEGGiocu:100008683.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051897 mRNA. Translation: AAC15422.1.
RefSeqiNP_001075504.1. NM_001082035.1. [O62742-1]
UniGeneiOcu.2203.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C44X-ray1.80A425-547[»]
ProteinModelPortaliO62742.
SMRiO62742.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000019823.

Proteomic databases

PRIDEiO62742.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008683.
KEGGiocu:100008683.

Organism-specific databases

CTDi6342.

Phylogenomic databases

eggNOGiKOG1406. Eukaryota.
KOG4170. Eukaryota.
ENOG410XPRW. LUCA.
HOGENOMiHOG000221741.
HOVERGENiHBG006506.
InParanoidiO62742.
KOiK08764.

Miscellaneous databases

EvolutionaryTraceiO62742.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
3.40.47.10. 4 hits.
InterProiIPR003033. SCP2_sterol-bd_dom.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02036. SCP2. 1 hit.
PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
SSF55718. SSF55718. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNLTP_RABIT
AccessioniPrimary (citable) accession number: O62742
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.