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Protein

Keratocan

Gene

KERA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Keratocan
Short name:
KTN
Alternative name(s):
Corneal keratan sulfate proteoglycan 37A core protein
Keratan sulfate proteoglycan keratocan
Short name:
KSPG keratocan
Gene namesi
Name:KERA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 352332KeratocanPRO_0000032747Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi93 – 931N-linked (GlcNAc...) (keratan sulfate)By similarity
Glycosylationi167 – 1671N-linked (GlcNAc...) (keratan sulfate)By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence analysis
Glycosylationi260 – 2601N-linked (GlcNAc...) (keratan sulfate)By similarity
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence analysis
Disulfide bondi303 ↔ 343By similarity

Post-translational modificationi

Binds three long, highly sulfated keratan sulfate chains in the cornea but short, non-sulfated poly(N-acetyllactosamine) chains in other tissues.
The N-terminus is blocked.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiO62702.
PRIDEiO62702.

Expressioni

Tissue specificityi

Abundant in cornea and sclera but also found in other tissues.1 Publication

Gene expression databases

BgeeiENSBTAG00000014340.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019066.

Structurei

3D structure databases

ProteinModelPortaliO62702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 7139LRRNTAdd
BLAST
Repeati72 – 9322LRR 1Add
BLAST
Repeati96 – 11722LRR 2Add
BLAST
Repeati122 – 14221LRR 3Add
BLAST
Repeati143 – 16422LRR 4Add
BLAST
Repeati167 – 18014LRR 5Add
BLAST
Repeati193 – 21422LRR 6Add
BLAST
Repeati215 – 23521LRR 7Add
BLAST
Repeati238 – 25821LRR 8Add
BLAST
Repeati263 – 28220LRR 9Add
BLAST
Repeati283 – 30422LRR 10Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 5817Cys-richAdd
BLAST

Sequence similaritiesi

Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiO62702.
KOiK08123.
TreeFamiTF334562.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O62702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTICFILW VVFVTDTVWT RSVRQVYEAS DPEDWTMHDF DCPRECFCPP
60 70 80 90 100
SFPTALYCEN RGLKEIPAIP SRIWYLYLEN NLIETIPEKP FENATQLRWI
110 120 130 140 150
NLNKNKITNY GIEKGALSQL KKLLFLFLED NELEEVPSPL PRSLEQLQLA
160 170 180 190 200
RNKVSRIPQG TFSNLENLTL LDLQHNKLLD NAFQRDTFKG LKNLMQLNMA
210 220 230 240 250
KNALRNMPPR LPANTMQVFL DNNSIEGIPE NYFNVIPKVA FLRLNHNKLS
260 270 280 290 300
DAGLPSSGFN VSSILDLQLS HNQLTKVPKI SAHLQHLHLD HNKIRNVNVS
310 320 330 340 350
VICPSTPTTL PVEDSFSYGP HLRYLRLDGN EIKPPIPMDL MTCFRLLQAV

II
Length:352
Mass (Da):40,406
Last modified:May 15, 2007 - v2
Checksum:iC16E4072CF4A85F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti189 – 1891K → R in AAC69272 (PubMed:9751803).Curated
Sequence conflicti218 – 2181V → L in AAI20376 (Ref. 3) Curated
Sequence conflicti288 – 2881H → Y in AAI20376 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48360 mRNA. Translation: AAC48568.1.
AF036962 Genomic DNA. Translation: AAC69272.1.
BC120375 mRNA. Translation: AAI20376.1.
RefSeqiNP_776335.1. NM_173910.1.
XP_010803060.1. XM_010804758.2.
XP_015326371.1. XM_015470885.1.
UniGeneiBt.5391.

Genome annotation databases

GeneIDi280785.
KEGGibta:280785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48360 mRNA. Translation: AAC48568.1.
AF036962 Genomic DNA. Translation: AAC69272.1.
BC120375 mRNA. Translation: AAI20376.1.
RefSeqiNP_776335.1. NM_173910.1.
XP_010803060.1. XM_010804758.2.
XP_015326371.1. XM_015470885.1.
UniGeneiBt.5391.

3D structure databases

ProteinModelPortaliO62702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019066.

Proteomic databases

PaxDbiO62702.
PRIDEiO62702.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280785.
KEGGibta:280785.

Organism-specific databases

CTDi11081.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiO62702.
KOiK08123.
TreeFamiTF334562.

Gene expression databases

BgeeiENSBTAG00000014340.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKERA_BOVIN
AccessioniPrimary (citable) accession number: O62702
Secondary accession number(s): Q0VC34, Q28032
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 15, 2007
Last modified: September 7, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.