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Protein

Beta-defensin 1

Gene

DEFB1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 1
Short name:
BD-1
Alternative name(s):
Defensin, beta 1
Gene namesi
Name:DEFB1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 15

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Propeptidei21 – 233By similarityPRO_0000006957
Peptidei24 – 6441Beta-defensin 1PRO_0000006958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 60By similarity
Disulfide bondi38 ↔ 53By similarity
Disulfide bondi43 ↔ 61By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO62697.

Expressioni

Gene expression databases

GenevisibleiO62697. SS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025388.

Structurei

3D structure databases

ProteinModelPortaliO62697.
SMRiO62697. Positions 28-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JJAE. Eukaryota.
ENOG411147G. LUCA.
GeneTreeiENSGT00730000112203.
HOVERGENiHBG004834.
InParanoidiO62697.
OMAiINNPITC.
OrthoDBiEOG091G1ANZ.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
IPR006080. Defensin_beta/alpha.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O62697-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLHRLLLVF LLMVLLPVPG LLKNIGNSVS CLRNKGVCMP GKCAPKMKQI
60
GTCGMPQVKC CKRK
Length:64
Mass (Da):7,066
Last modified:August 1, 1998 - v1
Checksum:i0A4B7494BA3E337A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031666 mRNA. Translation: AAC39175.1.
AF132038 Genomic DNA. Translation: AAD51137.1.
RefSeqiNP_999003.1. NM_213838.1.
UniGeneiSsc.16109.

Genome annotation databases

EnsembliENSSSCT00000024650; ENSSSCP00000025388; ENSSSCG00000027555.
ENSSSCT00000031084; ENSSSCP00000022776; ENSSSCG00000020997.
GeneIDi396819.
KEGGissc:396819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031666 mRNA. Translation: AAC39175.1.
AF132038 Genomic DNA. Translation: AAD51137.1.
RefSeqiNP_999003.1. NM_213838.1.
UniGeneiSsc.16109.

3D structure databases

ProteinModelPortaliO62697.
SMRiO62697. Positions 28-63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025388.

Proteomic databases

PaxDbiO62697.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000024650; ENSSSCP00000025388; ENSSSCG00000027555.
ENSSSCT00000031084; ENSSSCP00000022776; ENSSSCG00000020997.
GeneIDi396819.
KEGGissc:396819.

Organism-specific databases

CTDi1672.

Phylogenomic databases

eggNOGiENOG410JJAE. Eukaryota.
ENOG411147G. LUCA.
GeneTreeiENSGT00730000112203.
HOVERGENiHBG004834.
InParanoidiO62697.
OMAiINNPITC.
OrthoDBiEOG091G1ANZ.

Gene expression databases

GenevisibleiO62697. SS.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
IPR006080. Defensin_beta/alpha.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEFB1_PIG
AccessioniPrimary (citable) accession number: O62697
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.