O62696 (ARY1_FELCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arylamine N-acetyltransferase 1
EC=2.3.1.5

Alternative name(s):
Arylamide acetylase 1
N-acetyltransferase type 1
Short name=NAT-1

Gene names

Name:	NAT1
Synonyms:	NAT

Organism

Felis catus (Cat) (Felis silvestris catus) [Complete proteome]

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	258 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Participates in the detoxification of a plethora of hydrazine and arylamine drugs.
Catalytic activity	Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the arylamine N-acetyltransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	arylamine N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›258	›258	Arylamine N-acetyltransferase 1		PRO_0000107903
Regions
	Region	97 – 98	2	Substrate binding By similarity
Sites
	Active site	59	1	Acyl-thioester intermediate By similarity
	Active site	98	1	By similarity
	Active site	113	1	By similarity
	Binding site	199	1	Coenzyme A By similarity
	Binding site	205	1	Coenzyme A By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	258	1

Sequences

	Sequence		Length	Mass (Da)
	O62696 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: AD31B8745E79F2C3	FASTA	258	30,138
	10 20 30 40 50 60 IGYKNARNKL DLETLTDILQ HQIRAIPFEN LNIHCGETME LGLKAIFEQV VWRNRGGWCL 70 80 90 100 110 120 QVNHLLYWVL TTIGYETTML GGYVYSTAAN KYSNAMIHLL LKVTTEGKNY IVDAGFGRSY 130 140 150 160 170 180 QMWQPLELIS GKDQLQVPCI FRLTEERGIW YLDQIRRQQY IANEEFLNSD LLEKNKYRKI 190 200 210 220 230 240 YSFTLEPRTI EDFESVNTYL QTSPTSVFTS KSFCSLQTSE GVHCLVGCTL TYRKFNYKDN 250 MDLVEFKVLN EEEVEQKL

References

[1]	"Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene." Trepanier L.A., Cribb A.E., Spielberg S.P., Ray K. Pharmacogenetics 8:169-179(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF030398 Genomic DNA. Translation: AAC18940.1.
3D structure databases
ProteinModelPortal	O62696.
SMR	O62696. Positions 1-258.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000165.
Family and domain databases
InterPro	IPR001447. Arylamine_N-AcTrfase. [Graphical view]
PANTHER	PTHR11786. PTHR11786. 1 hit.
Pfam	PF00797. Acetyltransf_2. 1 hit. [Graphical view]
PRINTS	PR01543. ANATRNSFRASE.
ProtoNet	Search...

Entry information

Entry name

ARY1_FELCA

Accession

Primary (citable) accession number: O62696

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program