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Protein

Pro-interleukin-16

Gene

IL16

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4 (By similarity).By similarity
Pro-interleukin-16 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-interleukin-16
Cleaved into the following chain:
Interleukin-16
Short name:
IL-16
Alternative name(s):
Lymphocyte chemoattractant factor
Short name:
LCF
Gene namesi
Name:IL16
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Interleukin-16 :

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630Pro-interleukin-16PRO_0000377545Add
BLAST
Chaini510 – 630121Interleukin-16By similarityPRO_0000015416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer (Probable). Pro-interleukin-16 interacts (via PDZ 2 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Pro-interleukin-16 interacts with GRIN2A. Pro-interleukin-16 interacts with GABPB1. Pro-interleukin-16 interacts (via PDZ 3 domain) with HDAC3 (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000015164.

Structurei

3D structure databases

ProteinModelPortaliO62675.
SMRiO62675. Positions 401-630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini410 – 49586PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini532 – 61786PDZ 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni404 – 50097Interaction with PPP1R12A, PPP1R12B and PPP1R12CBy similarityAdd
BLAST

Sequence similaritiesi

Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
HOGENOMiHOG000081749.
HOVERGENiHBG000100.
InParanoidiO62675.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR020450. IL-16.
IPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 2 hits.
[Graphical view]
PRINTSiPR01931. INTRLEUKIN16.
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O62675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYSFDTTAE DPWVRISDCI KNLFSPIMSE NPGHMPLQPN ASLSEEDGTQ
60 70 80 90 100
GHPDGNPPKL DTANGTPKVY KSADRSTVKK GPPVAPKPAW FRQSLKGLRN
110 120 130 140 150
RASDPRGLPD PALSTQPAPA SREHLGPHIR ASSSSSIKQR ISSFETFGSS
160 170 180 190 200
QLPDKGAQRL SLQPSSGEAA KPLGKHEGGR FSGLLGRGAA PTLVPQQPEQ
210 220 230 240 250
VLPSGSPAAT EARDPGVSES PPPGLQPNQK TLPTGSDPLL RLLPTQTEKS
260 270 280 290 300
QGPVLKMPSQ RARSFPLTRS QSCETKLLDE KTSKLYSISS QVSSAVMKSL
310 320 330 340 350
LCLPSSLSCA QTPCIPKEGA SPTSSSNEDS AANGSAETSA SDTGFSLNLS
360 370 380 390 400
ELREYTEGLT EAKEDDDGDH SSHQSGQSVI SLLSSEELKQ LIEEVKVLDE
410 420 430 440 450
ATLKQLDSIH VTILHKEEGA GLGFSLAGGA DLENKVITVH KVFPNGLASQ
460 470 480 490 500
EGTIQKGNEV LSINGKSLKG TTHNDALAIL RQAREPRQAV IVTRKLTAES
510 520 530 540 550
MPDLNSTTDS AASASAASDV SVESSAEATV YTVTLEKMSA GLGFSLEGGK
560 570 580 590 600
GSLHGDKPLT INRIFKGAAS EQSETIQPGD EILQLAGTAM QGLTRFEAWN
610 620 630
IIKALPDGPV TIVIRRKSLQ PKETTAAADS
Length:630
Mass (Da):66,563
Last modified:August 1, 1998 - v1
Checksum:i9689007AB1781EDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017107 mRNA. Translation: AAC16035.1.
RefSeqiNP_001027980.1. NM_001032808.1.
UniGeneiMmu.2764.
Mmu.35167.

Genome annotation databases

GeneIDi574100.
KEGGimcc:574100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017107 mRNA. Translation: AAC16035.1.
RefSeqiNP_001027980.1. NM_001032808.1.
UniGeneiMmu.2764.
Mmu.35167.

3D structure databases

ProteinModelPortaliO62675.
SMRiO62675. Positions 401-630.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000015164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574100.
KEGGimcc:574100.

Organism-specific databases

CTDi3603.

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
HOGENOMiHOG000081749.
HOVERGENiHBG000100.
InParanoidiO62675.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR020450. IL-16.
IPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 2 hits.
[Graphical view]
PRINTSiPR01931. INTRLEUKIN16.
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL16_MACMU
AccessioniPrimary (citable) accession number: O62675
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.