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Protein

Cytochrome P450 2C41

Gene

CYP2C41

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi434 – 4341Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C41 (EC:1.14.14.1)
Alternative name(s):
CYPIIC41
Gene namesi
Name:CYP2C41
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Cytochrome P450 2C41PRO_0000051724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481N6-acetyllysineBy similarity
Modified residuei374 – 3741N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliO62671.
SMRiO62671. Positions 30-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.
InParanoidiO62671.
KOiK07413.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPVVVLVLC LSCCLLLSLW KQSSRKGKLP PGPTPLPFIG NILQLDKDIN
60 70 80 90 100
KSLSNLSKAY GPVFTLYFGM KPTVVLHGYD AVKETLIDLG EEFSARGRFP
110 120 130 140 150
IAEKVSGGHG IIFTSGNRWK EMRRFALTTL RNLGMGKSDL ESRVQEEACY
160 170 180 190 200
LVEELRKTNA LPCDPTFVLG CASCNVICSI IFQNRFDYTD QTLIGFLEKL
210 220 230 240 250
NENFRILSSP WIQAYNSFPA LLHYLPGSHN TIFKNFAFIK SYILEKIKEH
260 270 280 290 300
QESFDVNNPR DFIDYFLIKM EQEKHNQPLE FTFENLKTIA TDLFGAGTET
310 320 330 340 350
TSTTLRYGLL LLLKHPEVTV KVQEEIDRVI GRHQSPHMQD RSRMPYTNAV
360 370 380 390 400
LHEIQRYIDL VPNSLPHAVT CDVKFRNYVI PKGTTILISL SSVLSDEKEF
410 420 430 440 450
PRPEIFDPAH FLDDSGNFKK SDYFMAFSAG KRICVGEGLA RMELFLFLTT
460 470 480
ILQKFTLKPL VDPKDIDTTP LASGFGHVPP TYQLCFIPV
Length:489
Mass (Da):55,499
Last modified:August 1, 1998 - v1
Checksum:iBDAA6739BAAA8E15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016248 mRNA. Translation: AAC08738.1.
RefSeqiNP_001003334.1. NM_001003334.1.
UniGeneiCfa.3499.

Genome annotation databases

GeneIDi415123.
KEGGicfa:415123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016248 mRNA. Translation: AAC08738.1.
RefSeqiNP_001003334.1. NM_001003334.1.
UniGeneiCfa.3499.

3D structure databases

ProteinModelPortaliO62671.
SMRiO62671. Positions 30-489.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi415123.
KEGGicfa:415123.

Organism-specific databases

CTDi415123.

Phylogenomic databases

HOVERGENiHBG015789.
InParanoidiO62671.
KOiK07413.

Miscellaneous databases

NextBioi20818802.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of a new canine cytochrome P450 cDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression."
    Blaisdell J., Goldstein J.A., Bai S.A.
    Drug Metab. Dispos. 26:278-283(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP241_CANFA
AccessioniPrimary (citable) accession number: O62671
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: March 4, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.