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O62671 (CP241_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C41

EC=1.14.14.1
Alternative name(s):
CYPIIC41
Gene names
Name:CYP2C41
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Cytochrome P450 2C41
PRO_0000051724

Sites

Metal binding4341Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O62671 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: BDAA6739BAAA8E15

FASTA48955,499
        10         20         30         40         50         60 
MDPVVVLVLC LSCCLLLSLW KQSSRKGKLP PGPTPLPFIG NILQLDKDIN KSLSNLSKAY 

        70         80         90        100        110        120 
GPVFTLYFGM KPTVVLHGYD AVKETLIDLG EEFSARGRFP IAEKVSGGHG IIFTSGNRWK 

       130        140        150        160        170        180 
EMRRFALTTL RNLGMGKSDL ESRVQEEACY LVEELRKTNA LPCDPTFVLG CASCNVICSI 

       190        200        210        220        230        240 
IFQNRFDYTD QTLIGFLEKL NENFRILSSP WIQAYNSFPA LLHYLPGSHN TIFKNFAFIK 

       250        260        270        280        290        300 
SYILEKIKEH QESFDVNNPR DFIDYFLIKM EQEKHNQPLE FTFENLKTIA TDLFGAGTET 

       310        320        330        340        350        360 
TSTTLRYGLL LLLKHPEVTV KVQEEIDRVI GRHQSPHMQD RSRMPYTNAV LHEIQRYIDL 

       370        380        390        400        410        420 
VPNSLPHAVT CDVKFRNYVI PKGTTILISL SSVLSDEKEF PRPEIFDPAH FLDDSGNFKK 

       430        440        450        460        470        480 
SDYFMAFSAG KRICVGEGLA RMELFLFLTT ILQKFTLKPL VDPKDIDTTP LASGFGHVPP 


TYQLCFIPV 

« Hide

References

[1]"Isolation of a new canine cytochrome P450 cDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression."
Blaisdell J., Goldstein J.A., Bai S.A.
Drug Metab. Dispos. 26:278-283(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF016248 mRNA. Translation: AAC08738.1.
RefSeqNP_001003334.1. NM_001003334.1.
UniGeneCfa.3499.

3D structure databases

ProteinModelPortalO62671.
SMRO62671. Positions 30-489.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID415123.
KEGGcfa:415123.

Organism-specific databases

CTD415123.

Phylogenomic databases

HOVERGENHBG015789.
KOK07413.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20818802.

Entry information

Entry nameCP241_CANFA
AccessionPrimary (citable) accession number: O62671
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: December 11, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families