Reviewed, UniProtKB/Swiss-Prot O62671 (CP241_CANFA)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 2C41
    EC=1.14.14.1
Alternative name(s):
    CYPIIC41

Gene names

Name:

CYP2C41

Organism

Canis familiaris (Dog)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Cytochrome P450 2C41		PRO_0000051724
Sites
	Metal binding	434	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O62671-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: BDAA6739BAAA8E15	FASTA	489	55,499
	10 20 30 40 50 60 MDPVVVLVLC LSCCLLLSLW KQSSRKGKLP PGPTPLPFIG NILQLDKDIN KSLSNLSKAY 70 80 90 100 110 120 GPVFTLYFGM KPTVVLHGYD AVKETLIDLG EEFSARGRFP IAEKVSGGHG IIFTSGNRWK 130 140 150 160 170 180 EMRRFALTTL RNLGMGKSDL ESRVQEEACY LVEELRKTNA LPCDPTFVLG CASCNVICSI 190 200 210 220 230 240 IFQNRFDYTD QTLIGFLEKL NENFRILSSP WIQAYNSFPA LLHYLPGSHN TIFKNFAFIK 250 260 270 280 290 300 SYILEKIKEH QESFDVNNPR DFIDYFLIKM EQEKHNQPLE FTFENLKTIA TDLFGAGTET 310 320 330 340 350 360 TSTTLRYGLL LLLKHPEVTV KVQEEIDRVI GRHQSPHMQD RSRMPYTNAV LHEIQRYIDL 370 380 390 400 410 420 VPNSLPHAVT CDVKFRNYVI PKGTTILISL SSVLSDEKEF PRPEIFDPAH FLDDSGNFKK 430 440 450 460 470 480 SDYFMAFSAG KRICVGEGLA RMELFLFLTT ILQKFTLKPL VDPKDIDTTP LASGFGHVPP TYQLCFIPV

References

[1]

"Isolation of a new canine cytochrome P450 cDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression." Blaisdell J., Goldstein J.A., Bai S.A. Drug Metab. Dispos. 26:278-283(1998) [PubMed: 9492393] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF016248 mRNA. Translation: AAC08738.1.
RefSeq	NP_001003334.1.
UniGene	Cfa.3499
3D structure databases
SMR	O62671. Positions 30-489.
ModBase	Search...
Genome annotation databases
GeneID	415123.
KEGG	cfa:415123.
Organism-specific databases
CTD	415123.
Phylogenomic databases
HOVERGEN	O62671.
Enzyme and pathway databases
BRENDA	1.14.14.1. 463.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP241_CANFA

Accession

Primary (citable) accession number: O62671

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	January 19, 2010
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)