Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Desmin

Gene

DES

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei354 – 3541Stutter

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Enzyme and pathway databases

ReactomeiR-BTA-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Desmin
Gene namesi
Name:DES
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

  • CytoplasmmyofibrilsarcomereZ line By similarity
  • Cytoplasm By similarity
  • Cell membranesarcolemma By similarity

  • Note: Localizes in the intercalated disks which occur at the Z line of cardiomyocytes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Intermediate filament, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470DesminPRO_0000063769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphoserine; by AURKBBy similarity
Modified residuei17 – 171Phosphothreonine; by AURKBBy similarity
Modified residuei28 – 281PhosphoserineBy similarity
Modified residuei31 – 311PhosphoserineBy similarity
Modified residuei32 – 321PhosphoserineBy similarity
Modified residuei45 – 451PhosphoserineBy similarity
Modified residuei58 – 581ADP-ribosylarginineBy similarity
Modified residuei60 – 601Phosphoserine; by AURKBBy similarity
Modified residuei81 – 811PhosphoserineBy similarity
Modified residuei290 – 2901PhosphoserineBy similarity
Modified residuei358 – 3581PhosphoserineBy similarity
Modified residuei361 – 3611PhosphoserineBy similarity
Modified residuei424 – 4241PhosphoserineBy similarity

Post-translational modificationi

ADP-ribosylation prevents ability to form intermediate filaments.By similarity

Keywords - PTMi

ADP-ribosylation, Phosphoprotein

Proteomic databases

PaxDbiO62654.
PeptideAtlasiO62654.
PRIDEiO62654.

Interactioni

Subunit structurei

Homopolymer. Interacts with MTM1 and DST (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007041.

Structurei

3D structure databases

ProteinModelPortaliO62654.
SMRiO62654. Positions 106-143, 333-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 108108HeadAdd
BLAST
Regioni109 – 412304RodAdd
BLAST
Regioni109 – 14133Coil 1AAdd
BLAST
Regioni142 – 15110Linker 1
Regioni152 – 252101Coil 1BAdd
BLAST
Regioni253 – 26816Linker 12Add
BLAST
Regioni269 – 28719Coil 2AAdd
BLAST
Regioni288 – 2958Linker 2
Regioni296 – 412117Coil 2BAdd
BLAST
Regioni413 – 47058TailAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi45 – 484Poly-Ser

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFZ1. Eukaryota.
ENOG410XRBS. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230977.
HOVERGENiHBG013015.
InParanoidiO62654.
KOiK07610.
OMAiFPRTGFG.
OrthoDBiEOG7FV3Q8.
TreeFamiTF330122.

Family and domain databases

InterProiIPR027698. DES.
IPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR018039. Intermediate_filament_CS.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF28. PTHR23239:SF28. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF04732. Filament_head. 1 hit.
[Graphical view]
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAYSSSQR VSSYRRTFGG APSFPLGSPL SSPVFPRAGF GTKGSSSSVT
60 70 80 90 100
SRVYQVSRTS GGAGGLGALR ASRLGSTRVP SSYGAGELLD FSLADAVNQE
110 120 130 140 150
FLTTRTNEKV ELQELNDRFA NYIEKVRFLE QQNAALAAEV NRLKGREPTR
160 170 180 190 200
VAEIYEEELR ELRRQVEVLT NQRARVDVER DNLLDDLQRL KAKLQEEIQL
210 220 230 240 250
KEEAENNLAA FRADVDAATL ARIDLERRIE SLNEEIAFLK KVHEEEIREL
260 270 280 290 300
QAQLQEQQVQ VEMDMSKPDL TAALRDIRAQ YETIAAKNIS EAEEWYKSKV
310 320 330 340 350
SDLTQAANKN NDALRQAKQE MMEYRHQIQS YTCEIDALKG TNDSLMRQMR
360 370 380 390 400
ELEDRFASEA SGYQDNIARL EEEIRHLKDE MARHLREYQD LLNVKMALDV
410 420 430 440 450
EIATYRKLLE GEESRINLPI QTFSALNFRE TSPEQRGSEV HTKKTVMIKT
460 470
IETRDGEVVS EATQQQHEVL
Length:470
Mass (Da):53,532
Last modified:January 23, 2007 - v3
Checksum:iB642D20280B3FD54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011675 Genomic DNA. Translation: BAA25135.1.
AB011673 mRNA. Translation: BAA25133.1.
BC133410 mRNA. Translation: AAI33411.1.
RefSeqiNP_001075044.1. NM_001081575.1.
UniGeneiBt.6141.

Genome annotation databases

EnsembliENSBTAT00000007041; ENSBTAP00000007041; ENSBTAG00000005353.
GeneIDi280765.
KEGGibta:280765.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011675 Genomic DNA. Translation: BAA25135.1.
AB011673 mRNA. Translation: BAA25133.1.
BC133410 mRNA. Translation: AAI33411.1.
RefSeqiNP_001075044.1. NM_001081575.1.
UniGeneiBt.6141.

3D structure databases

ProteinModelPortaliO62654.
SMRiO62654. Positions 106-143, 333-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007041.

Proteomic databases

PaxDbiO62654.
PeptideAtlasiO62654.
PRIDEiO62654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007041; ENSBTAP00000007041; ENSBTAG00000005353.
GeneIDi280765.
KEGGibta:280765.

Organism-specific databases

CTDi1674.

Phylogenomic databases

eggNOGiENOG410IFZ1. Eukaryota.
ENOG410XRBS. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230977.
HOVERGENiHBG013015.
InParanoidiO62654.
KOiK07610.
OMAiFPRTGFG.
OrthoDBiEOG7FV3Q8.
TreeFamiTF330122.

Enzyme and pathway databases

ReactomeiR-BTA-390522. Striated Muscle Contraction.

Family and domain databases

InterProiIPR027698. DES.
IPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR018039. Intermediate_filament_CS.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF28. PTHR23239:SF28. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF04732. Filament_head. 1 hit.
[Graphical view]
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Desmin structure as related to meat tenderness."
    Chikuni K., Tanabe R., Muroya S.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Holstein.
    Tissue: Muscle.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal muscle.

Entry informationi

Entry nameiDESM_BOVIN
AccessioniPrimary (citable) accession number: O62654
Secondary accession number(s): A2VDU8, O62655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.