ID   PNOC_BOVIN              Reviewed;         176 AA.
AC   O62647;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   24-JAN-2024, entry version 119.
DE   RecName: Full=Prepronociceptin;
DE   Contains:
DE     RecName: Full=Nocistatin;
DE   Contains:
DE     RecName: Full=Nociceptin;
DE     AltName: Full=Orphanin FQ;
DE     AltName: Full=PPNOC;
DE   Contains:
DE     RecName: Full=Orphanin FQ2;
DE   Flags: Precursor;
GN   Name=PNOC;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION OF NOCISTATIN.
RX   PubMed=9521323; DOI=10.1038/32660;
RA   Okuda-Ashitaka E., Minami T., Tachibana S., Yoshihara Y., Nishiuchi Y.,
RA   Kimura T., Ito S.;
RT   "Nocistatin, a peptide that blocks nociceptin action in pain
RT   transmission.";
RL   Nature 392:286-289(1998).
CC   -!- FUNCTION: [Nociceptin]: Ligand of the opioid receptor-like receptor
CC       OPRL1. It may act as a transmitter in the brain by modulating
CC       nociceptive and locomotor behavior. May be involved in neuronal
CC       differentiation and development. {ECO:0000250|UniProtKB:P55791}.
CC   -!- FUNCTION: [Nocistatin]: Blocks nociceptin action in pain transmission
CC       by inhibiting nociceptin-induced hyperalgesia and allodynia.
CC       {ECO:0000269|PubMed:9521323}.
CC   -!- FUNCTION: [Orphanin FQ2]: Has potent analgesic activity.
CC       {ECO:0000250|UniProtKB:Q64387}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Specific enzymatic cleavages at paired basic residues probably
CC       yield other active peptides besides nociceptin.
CC   -!- PTM: The N-terminal domain contains 6 conserved cysteines thought to be
CC       involved in disulfide bonding and/or processing.
CC   -!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
CC       {ECO:0000305}.
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DR   EMBL; AB005251; BAA25419.1; -; mRNA.
DR   RefSeq; NP_776575.1; NM_174150.2.
DR   RefSeq; XP_015327885.1; XM_015472399.1.
DR   AlphaFoldDB; O62647; -.
DR   STRING; 9913.ENSBTAP00000000695; -.
DR   PaxDb; 9913-ENSBTAP00000000695; -.
DR   Ensembl; ENSBTAT00000000695.3; ENSBTAP00000000695.2; ENSBTAG00000000534.3.
DR   GeneID; 281414; -.
DR   KEGG; bta:281414; -.
DR   CTD; 5368; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000534; -.
DR   VGNC; VGNC:33089; PNOC.
DR   eggNOG; ENOG502S0DD; Eukaryota.
DR   GeneTree; ENSGT00950000183149; -.
DR   HOGENOM; CLU_143892_0_0_1; -.
DR   InParanoid; O62647; -.
DR   OMA; CREKLHP; -.
DR   TreeFam; TF332620; -.
DR   Reactome; R-BTA-375276; Peptide ligand-binding receptors.
DR   Reactome; R-BTA-418594; G alpha (i) signalling events.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000000534; Expressed in oocyte and 23 other cell types or tissues.
DR   GO; GO:0043679; C:axon terminus; IBA:GO_Central.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0097060; C:synaptic membrane; IEA:Ensembl.
DR   GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
DR   GO; GO:0031628; F:opioid receptor binding; IBA:GO_Central.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0007270; P:neuron-neuron synaptic transmission; IEA:Ensembl.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   GO; GO:0007600; P:sensory perception; IBA:GO_Central.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
DR   InterPro; IPR002367; Nociceptin.
DR   InterPro; IPR006024; Opioid_neupept.
DR   PANTHER; PTHR11438:SF2; PREPRONOCICEPTIN; 1.
DR   PANTHER; PTHR11438; PROENKEPHALIN; 1.
DR   Pfam; PF01160; Opiods_neuropep; 1.
DR   PRINTS; PR01028; OPIOIDPRCRSR.
DR   PRINTS; PR01031; ORPHNNPRCRSR.
DR   PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Neuropeptide;
KW   Neurotransmitter; Opioid peptide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..95
FT                   /id="PRO_0000008320"
FT   PEPTIDE         98..127
FT                   /note="Nocistatin"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000008321"
FT   PEPTIDE         130..146
FT                   /note="Nociceptin"
FT                   /evidence="ECO:0000250|UniProtKB:P55791"
FT                   /id="PRO_0000008322"
FT   PEPTIDE         149..165
FT                   /note="Orphanin FQ2"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000008323"
FT   PROPEP          169..176
FT                   /id="PRO_0000008324"
SQ   SEQUENCE   176 AA;  20256 MW;  0245B61BD81ECA26 CRC64;
     MKILFCDLLL LSLFSSVSSS CQKDCLVCRE KLRPTLDSFS LEMCILECEE KAFTSPLWTP
     CTKVMARGSW QLSPADPDHV AAALDQPRAS EMQHLKRMPR VRSLFQRQKR TEPGLEEVGE
     IEQKQLQKRF GGFTGARKSA RKLANQKRFS EFMRQYLVLS MQSSQRRRTL HQNGNA
//