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O62647

- PNOC_BOVIN

UniProt

O62647 - PNOC_BOVIN

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Protein

Prepronociceptin

Gene

PNOC

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development (By similarity).By similarity

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
  2. synaptic transmission Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter, Opioid peptide

Enzyme and pathway databases

ReactomeiREACT_210568. G alpha (i) signalling events.
REACT_219025. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prepronociceptin
Cleaved into the following 3 chains:
Alternative name(s):
Orphanin FQ
PPNOC
Gene namesi
Name:PNOC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 8

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 9576PRO_0000008320Add
BLAST
Peptidei98 – 12730Neuropeptide 1CuratedPRO_0000008321Add
BLAST
Peptidei130 – 14617NociceptinPRO_0000008322Add
BLAST
Peptidei149 – 16517Neuropeptide 2CuratedPRO_0000008323Add
BLAST
Propeptidei169 – 1768PRO_0000008324

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiO62647.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000695.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40726.
GeneTreeiENSGT00510000049153.
HOGENOMiHOG000082421.
HOVERGENiHBG008227.
InParanoidiO62647.
OMAiHLKRMPR.
OrthoDBiEOG7MH118.
TreeFamiTF332620.

Family and domain databases

InterProiIPR002367. Nociceptin.
IPR006024. Opioid_neupept.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01031. ORPHNNPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O62647-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKILFCDLLL LSLFSSVSSS CQKDCLVCRE KLRPTLDSFS LEMCILECEE
60 70 80 90 100
KAFTSPLWTP CTKVMARGSW QLSPADPDHV AAALDQPRAS EMQHLKRMPR
110 120 130 140 150
VRSLFQRQKR TEPGLEEVGE IEQKQLQKRF GGFTGARKSA RKLANQKRFS
160 170
EFMRQYLVLS MQSSQRRRTL HQNGNA
Length:176
Mass (Da):20,256
Last modified:August 1, 1998 - v1
Checksum:i0245B61BD81ECA26
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB005251 mRNA. Translation: BAA25419.1.
RefSeqiNP_776575.1. NM_174150.2.
XP_005209901.1. XM_005209844.1.
UniGeneiBt.199.

Genome annotation databases

EnsembliENSBTAT00000000695; ENSBTAP00000000695; ENSBTAG00000000534.
GeneIDi281414.
KEGGibta:281414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB005251 mRNA. Translation: BAA25419.1 .
RefSeqi NP_776575.1. NM_174150.2.
XP_005209901.1. XM_005209844.1.
UniGenei Bt.199.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000000695.

Proteomic databases

PRIDEi O62647.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000000695 ; ENSBTAP00000000695 ; ENSBTAG00000000534 .
GeneIDi 281414.
KEGGi bta:281414.

Organism-specific databases

CTDi 5368.

Phylogenomic databases

eggNOGi NOG40726.
GeneTreei ENSGT00510000049153.
HOGENOMi HOG000082421.
HOVERGENi HBG008227.
InParanoidi O62647.
OMAi HLKRMPR.
OrthoDBi EOG7MH118.
TreeFami TF332620.

Enzyme and pathway databases

Reactomei REACT_210568. G alpha (i) signalling events.
REACT_219025. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi 20805403.

Family and domain databases

InterProi IPR002367. Nociceptin.
IPR006024. Opioid_neupept.
[Graphical view ]
PANTHERi PTHR11438. PTHR11438. 1 hit.
Pfami PF01160. Opiods_neuropep. 1 hit.
[Graphical view ]
PRINTSi PR01028. OPIOIDPRCRSR.
PR01031. ORPHNNPRCRSR.
PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nocistatin, a peptide that blocks nociceptin action in pain transmission."
    Okuda-Ashitaka E., Minami T., Tachibana S., Yoshihara Y., Nishiuchi Y., Kimura T., Ito S.
    Nature 392:286-289(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPNOC_BOVIN
AccessioniPrimary (citable) accession number: O62647
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3