O62647 (PNOC_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prepronociceptin

Cleaved into the following 3 chains:

1. Neuropeptide 1
2. Nociceptin
   Alternative name(s):
   Orphanin FQ
   PPNOC
3. Neuropeptide 2

Gene names

Name:

PNOC

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development By similarity.
Subcellular location	Secreted.
Post-translational modification	Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Sequence similarities	Belongs to the opioid neuropeptide precursor family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Neuropeptide Neurotransmitter Opioid peptide
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW synaptic transmission Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 95	76			PRO_0000008320
	Peptide	98 – 127	30	Neuropeptide 1 Probable		PRO_0000008321
	Peptide	130 – 146	17	Nociceptin		PRO_0000008322
	Peptide	149 – 165	17	Neuropeptide 2 Probable		PRO_0000008323
	Propeptide	169 – 176	8			PRO_0000008324

Sequences

	Sequence		Length	Mass (Da)
	O62647 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 0245B61BD81ECA26	FASTA	176	20,256
	10 20 30 40 50 60 MKILFCDLLL LSLFSSVSSS CQKDCLVCRE KLRPTLDSFS LEMCILECEE KAFTSPLWTP 70 80 90 100 110 120 CTKVMARGSW QLSPADPDHV AAALDQPRAS EMQHLKRMPR VRSLFQRQKR TEPGLEEVGE 130 140 150 160 170 IEQKQLQKRF GGFTGARKSA RKLANQKRFS EFMRQYLVLS MQSSQRRRTL HQNGNA

References

[1]	"Nocistatin, a peptide that blocks nociceptin action in pain transmission." Okuda-Ashitaka E., Minami T., Tachibana S., Yoshihara Y., Nishiuchi Y., Kimura T., Ito S. Nature 392:286-289(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB005251 mRNA. Translation: BAA25419.1.
IPI	IPI00695461.
RefSeq	NP_776575.1. NM_174150.2.
UniGene	Bt.199.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000000695.
Proteomic databases
PRIDE	O62647.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000000695; ENSBTAP00000000695; ENSBTAG00000000534.
GeneID	281414.
KEGG	bta:281414.
Organism-specific databases
CTD	5368.
Phylogenomic databases
eggNOG	NOG40726.
GeneTree	ENSGT00510000049153.
HOGENOM	HOG000082421.
HOVERGEN	HBG008227.
InParanoid	O62647.
OMA	HLKRMPR.
OrthoDB	EOG44BB3B.
Family and domain databases
InterPro	IPR002367. Nociceptin. IPR006024. Opioid_neupept. [Graphical view]
PANTHER	PTHR11438. PTHR11438. 1 hit.
Pfam	PF01160. Opiods_neuropep. 1 hit. [Graphical view]
PRINTS	PR01028. OPIOIDPRCRSR. PR01031. ORPHNNPRCRSR.
PROSITE	PS01252. OPIOIDS_PRECURSOR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20805403.

Entry information

Entry name

PNOC_BOVIN

Accession

Primary (citable) accession number: O62647

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 1, 1998
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program