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O62647

- PNOC_BOVIN

UniProt

O62647 - PNOC_BOVIN

Protein

Prepronociceptin

Gene

PNOC

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development By similarity.By similarity

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW
    2. synaptic transmission Source: UniProtKB-KW

    Keywords - Molecular functioni

    Neuropeptide, Neurotransmitter, Opioid peptide

    Enzyme and pathway databases

    ReactomeiREACT_210568. G alpha (i) signalling events.
    REACT_219025. Peptide ligand-binding receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prepronociceptin
    Cleaved into the following 3 chains:
    Alternative name(s):
    Orphanin FQ
    PPNOC
    Gene namesi
    Name:PNOC
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 8

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 9576PRO_0000008320Add
    BLAST
    Peptidei98 – 12730Neuropeptide 1CuratedPRO_0000008321Add
    BLAST
    Peptidei130 – 14617NociceptinPRO_0000008322Add
    BLAST
    Peptidei149 – 16517Neuropeptide 2CuratedPRO_0000008323Add
    BLAST
    Propeptidei169 – 1768PRO_0000008324

    Post-translational modificationi

    Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiO62647.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000000695.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40726.
    GeneTreeiENSGT00510000049153.
    HOGENOMiHOG000082421.
    HOVERGENiHBG008227.
    InParanoidiO62647.
    OMAiHLKRMPR.
    OrthoDBiEOG7MH118.
    TreeFamiTF332620.

    Family and domain databases

    InterProiIPR002367. Nociceptin.
    IPR006024. Opioid_neupept.
    [Graphical view]
    PANTHERiPTHR11438. PTHR11438. 1 hit.
    PfamiPF01160. Opiods_neuropep. 1 hit.
    [Graphical view]
    PRINTSiPR01028. OPIOIDPRCRSR.
    PR01031. ORPHNNPRCRSR.
    PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O62647-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILFCDLLL LSLFSSVSSS CQKDCLVCRE KLRPTLDSFS LEMCILECEE    50
    KAFTSPLWTP CTKVMARGSW QLSPADPDHV AAALDQPRAS EMQHLKRMPR 100
    VRSLFQRQKR TEPGLEEVGE IEQKQLQKRF GGFTGARKSA RKLANQKRFS 150
    EFMRQYLVLS MQSSQRRRTL HQNGNA 176
    Length:176
    Mass (Da):20,256
    Last modified:August 1, 1998 - v1
    Checksum:i0245B61BD81ECA26
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005251 mRNA. Translation: BAA25419.1.
    RefSeqiNP_776575.1. NM_174150.2.
    XP_005209901.1. XM_005209844.1.
    UniGeneiBt.199.

    Genome annotation databases

    EnsembliENSBTAT00000000695; ENSBTAP00000000695; ENSBTAG00000000534.
    GeneIDi281414.
    KEGGibta:281414.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005251 mRNA. Translation: BAA25419.1 .
    RefSeqi NP_776575.1. NM_174150.2.
    XP_005209901.1. XM_005209844.1.
    UniGenei Bt.199.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000000695.

    Proteomic databases

    PRIDEi O62647.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000000695 ; ENSBTAP00000000695 ; ENSBTAG00000000534 .
    GeneIDi 281414.
    KEGGi bta:281414.

    Organism-specific databases

    CTDi 5368.

    Phylogenomic databases

    eggNOGi NOG40726.
    GeneTreei ENSGT00510000049153.
    HOGENOMi HOG000082421.
    HOVERGENi HBG008227.
    InParanoidi O62647.
    OMAi HLKRMPR.
    OrthoDBi EOG7MH118.
    TreeFami TF332620.

    Enzyme and pathway databases

    Reactomei REACT_210568. G alpha (i) signalling events.
    REACT_219025. Peptide ligand-binding receptors.

    Miscellaneous databases

    NextBioi 20805403.

    Family and domain databases

    InterProi IPR002367. Nociceptin.
    IPR006024. Opioid_neupept.
    [Graphical view ]
    PANTHERi PTHR11438. PTHR11438. 1 hit.
    Pfami PF01160. Opiods_neuropep. 1 hit.
    [Graphical view ]
    PRINTSi PR01028. OPIOIDPRCRSR.
    PR01031. ORPHNNPRCRSR.
    PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nocistatin, a peptide that blocks nociceptin action in pain transmission."
      Okuda-Ashitaka E., Minami T., Tachibana S., Yoshihara Y., Nishiuchi Y., Kimura T., Ito S.
      Nature 392:286-289(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPNOC_BOVIN
    AccessioniPrimary (citable) accession number: O62647
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3