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O62647 (PNOC_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prepronociceptin

Cleaved into the following 3 chains:

  1. Neuropeptide 1
  2. Nociceptin
    Alternative name(s):
    Orphanin FQ
    PPNOC
  3. Neuropeptide 2
Gene names
Name:PNOC
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development By similarity.

Subcellular location

Secreted.

Post-translational modification

Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Sequence similarities

Belongs to the opioid neuropeptide precursor family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionNeuropeptide
Neurotransmitter
Opioid peptide
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processneuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

synaptic transmission

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 9576
PRO_0000008320
Peptide98 – 12730Neuropeptide 1 Probable
PRO_0000008321
Peptide130 – 14617Nociceptin
PRO_0000008322
Peptide149 – 16517Neuropeptide 2 Probable
PRO_0000008323
Propeptide169 – 1768
PRO_0000008324

Sequences

Sequence LengthMass (Da)Tools
O62647 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 0245B61BD81ECA26

FASTA17620,256
        10         20         30         40         50         60 
MKILFCDLLL LSLFSSVSSS CQKDCLVCRE KLRPTLDSFS LEMCILECEE KAFTSPLWTP 

        70         80         90        100        110        120 
CTKVMARGSW QLSPADPDHV AAALDQPRAS EMQHLKRMPR VRSLFQRQKR TEPGLEEVGE 

       130        140        150        160        170 
IEQKQLQKRF GGFTGARKSA RKLANQKRFS EFMRQYLVLS MQSSQRRRTL HQNGNA 

« Hide

References

[1]"Nocistatin, a peptide that blocks nociceptin action in pain transmission."
Okuda-Ashitaka E., Minami T., Tachibana S., Yoshihara Y., Nishiuchi Y., Kimura T., Ito S.
Nature 392:286-289(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB005251 mRNA. Translation: BAA25419.1.
RefSeqNP_776575.1. NM_174150.2.
XP_005209901.1. XM_005209844.1.
UniGeneBt.199.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000000695.

Proteomic databases

PRIDEO62647.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000000695; ENSBTAP00000000695; ENSBTAG00000000534.
GeneID281414.
KEGGbta:281414.

Organism-specific databases

CTD5368.

Phylogenomic databases

eggNOGNOG40726.
GeneTreeENSGT00510000049153.
HOGENOMHOG000082421.
HOVERGENHBG008227.
InParanoidO62647.
OMAHLKRMPR.
OrthoDBEOG7MH118.
TreeFamTF332620.

Family and domain databases

InterProIPR002367. Nociceptin.
IPR006024. Opioid_neupept.
[Graphical view]
PANTHERPTHR11438. PTHR11438. 1 hit.
PfamPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSPR01028. OPIOIDPRCRSR.
PR01031. ORPHNNPRCRSR.
PROSITEPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805403.

Entry information

Entry namePNOC_BOVIN
AccessionPrimary (citable) accession number: O62647
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families