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Protein

Synaptophysin-like protein 2

Gene

SYPL2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.1 Publication

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin-like protein 2
Alternative name(s):
Mitsugumin-29
Short name:
Mg29
Gene namesi
Name:SYPL2
Synonyms:MG29
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence analysisAdd
BLAST
Transmembranei34 – 5421HelicalSequence analysisAdd
BLAST
Topological domaini55 – 11662VesicularSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Topological domaini138 – 15013CytoplasmicSequence analysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence analysisAdd
BLAST
Topological domaini172 – 21342VesicularSequence analysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence analysisAdd
BLAST
Topological domaini235 – 26430CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Synaptophysin-like protein 2PRO_0000179168Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Skeletal muscle.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001314.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 238209MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF8N. Eukaryota.
ENOG4111ZDM. LUCA.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiO62646.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTESPSRA ADKSPRQQVD RLLEGLRWRR LEEPLGFIKV LQWLFAIFAF
60 70 80 90 100
GSCGSYSGET GAMVRCNNEA KDVSSIIVLF GYPFRLHRIE YEMPLCDDDS
110 120 130 140 150
SSKTMHLMGD FSAPAEFFVT LGIFSFFYTM AALVVYLRFH KLYTENKRFP
160 170 180 190 200
LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG ATRPSSLTAA MSVCHGEEAV
210 220 230 240 250
CSAGATPSMG LANISVLFGF INFFLWAGNC WFVFKETPWH GQGQDQGQGP
260
SQESAAEQGA VEKQ
Length:264
Mass (Da):29,312
Last modified:August 1, 1998 - v1
Checksum:iCE534B48BC060845
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004816 mRNA. Translation: BAA25784.1.
RefSeqiNP_001075455.1. NM_001081986.1.
UniGeneiOcu.2202.

Genome annotation databases

GeneIDi100008596.
KEGGiocu:100008596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004816 mRNA. Translation: BAA25784.1.
RefSeqiNP_001075455.1. NM_001081986.1.
UniGeneiOcu.2202.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008596.
KEGGiocu:100008596.

Organism-specific databases

CTDi284612.

Phylogenomic databases

eggNOGiENOG410IF8N. Eukaryota.
ENOG4111ZDM. LUCA.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiO62646.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYPL2_RABIT
AccessioniPrimary (citable) accession number: O62646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.