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Protein

Thy-1 membrane glycoprotein

Gene

THY1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thy-1 membrane glycoprotein
Alternative name(s):
Thy-1 antigen
CD_antigen: CD90
Gene namesi
Name:THY1
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001497520 – 130Thy-1 membrane glycoproteinAdd BLAST111
PropeptideiPRO_0000014976131 – 161Removed in mature formBy similarityAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi28 ↔ 130AlternatePROSITE-ProRule annotation
Disulfide bondi38 ↔ 104PROSITE-ProRule annotation
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Modified residuei82PhosphoserineBy similarity1
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Lipidationi130GPI-anchor amidated cysteine; alternateBy similarity1
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiO62643.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000011701.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 126Ig-like V-typeAdd BLAST107

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IVXA. Eukaryota.
ENOG410YYC2. LUCA.
HOGENOMiHOG000048719.
HOVERGENiHBG002958.
InParanoidiO62643.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
IPR033292. THY1.
[Graphical view]
PANTHERiPTHR19226:SF2. PTHR19226:SF2. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O62643-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLAISIALL LTVLQVSRGQ KVTSLTACLV DQSLRLDCRH ENTTSSPIQY
60 70 80 90 100
EFSLTRETKK HVLFGTVGVP EHTYRSRTNF TSKYNMKVLY LSAFTXKDEG
110 120 130 140 150
TYTCXLHHSG HSPPISSQNV TVLRDKLVKC EGISLLAQNT SWLXLLLLSL
160
SLLQATDFMS L
Length:161
Mass (Da):18,011
Last modified:August 1, 1998 - v1
Checksum:i326B135498BA401B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93310 mRNA. Translation: AAC05640.1.
UniGeneiMmu.1976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93310 mRNA. Translation: AAC05640.1.
UniGeneiMmu.1976.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000011701.

Proteomic databases

PRIDEiO62643.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IVXA. Eukaryota.
ENOG410YYC2. LUCA.
HOGENOMiHOG000048719.
HOVERGENiHBG002958.
InParanoidiO62643.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
IPR033292. THY1.
[Graphical view]
PANTHERiPTHR19226:SF2. PTHR19226:SF2. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHY1_MACMU
AccessioniPrimary (citable) accession number: O62643
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: October 5, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.