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Protein

Coatomer subunit beta'

Gene

beta'COP

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-DME-6807878 COPI-mediated anterograde transport
R-DME-6811434 COPI-dependent Golgi-to-ER retrograde traffic
SignaLinkiO62621

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit beta'
Alternative name(s):
Beta'-coat protein
Short name:
Beta'-COP
Gene namesi
Name:beta'COPImported
ORF Names:CG6699Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0025724 beta'COP

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509161 – 914Coatomer subunit beta'Add BLAST914

Proteomic databases

PaxDbiO62621
PRIDEiO62621

Expressioni

Gene expression databases

BgeeiFBgn0025724
GenevisibleiO62621 DM

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.By similarity

Protein-protein interaction databases

BioGridi69859, 13 interactors
DIPiDIP-22262N
IntActiO62621, 3 interactors
STRINGi7227.FBpp0080048

Structurei

3D structure databases

ProteinModelPortaliO62621
SMRiO62621
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 54WD 1Add BLAST42
Repeati55 – 94WD 2Add BLAST40
Repeati97 – 136WD 3Add BLAST40
Repeati140 – 180WD 4Add BLAST41
Repeati183 – 224WD 5Add BLAST42
Repeati227 – 266WD 6Add BLAST40
Repeati352 – 390WD 7Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat COPB2 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0276 Eukaryota
ENOG410XNNY LUCA
GeneTreeiENSGT00900000141083
InParanoidiO62621
KOiK17302
OMAiNHETQTL
OrthoDBiEOG091G0284
PhylomeDBiO62621

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR006692 Coatomer_WD-assoc_reg
IPR016453 COPB2
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF04053 Coatomer_WDAD, 1 hit
PF00400 WD40, 4 hits
PIRSFiPIRSF005567 Coatomer_beta'_subunit, 1 hit
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O62621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLKLDIKRR LTSRSDRVKC VDLHPAEPWM LCALYNGHVH IMNYENQQMV
60 70 80 90 100
KDFEVCDVPV RSARFVARKN WILTGSDDMQ IRVFNYNTLE KVHSFEAHSD
110 120 130 140 150
YLRCIAVHPT QPLVLTSSDD MLIKLWNWEK MWACQRVFEG HTHYVMQIVF
160 170 180 190 200
NPKDNNTFAS ASLDRTVKVW QLGSNFANFT LEGHEKGVNC VDYYHGGDKP
210 220 230 240 250
YLISGADDRL VKIWDYQNKT CVQTLEGHAQ NISAVCFHPE LPIVLTGSED
260 270 280 290 300
GTVRIWHSGT YRLETCLNYG FERVWTISSM RGTNNVALGY DEGSIIIKVG
310 320 330 340 350
REEPAMSMDV VGSKIIWAKH SEMQQVNLKT IADGTEIKDG ERLPVATKDM
360 370 380 390 400
GACEIYPQTI AHNPNGRFVV VCGDGEYIIY TSMALRNKAF GSAQEFVWAL
410 420 430 440 450
ESNEYAIREN NGTVRLFRNF KERKSFTPEY GAESIYGGYY FGVKTSSGLA
460 470 480 490 500
FYDWETLQLV RRIEVQPKNV FWNESGSLVC LATDDSYFVL GVDTAQVANA
510 520 530 540 550
VETKEGLEDD GVESAFNVLG EVSECVKTGL WVGDCFIYTN SVNRINYYVG
560 570 580 590 600
GEIVTVSHLD RTMYLLGYVP KDNRIYLGDK ELNVISFCLQ LSVLEYQTAV
610 620 630 640 650
MRRDFERADV VLPTIPKEHR TRVAHFLEKQ GFKSQALQVS TDADHKFDLA
660 670 680 690 700
LQIGDLEIAL KLARESENSQ KWSQLADVAS SKNNMSLVKE CMQKANDLSG
710 720 730 740 750
LLLLSTASGD AQLLEVVGAA GSAQGHHNLA FLSAFLRSDV ERCLEILIET
760 770 780 790 800
NRLPEAAFFA RTYLPSQMSR IVELWREKLG KVNEKAGQSL ADPAQYTNLF
810 820 830 840 850
PGLGDALRVE QHLQEERARK APARLAANLP LNSERHPLQE LFAAEQGAAG
860 870 880 890 900
QHLEEKVKPA YVPAQAVVSS SQVAEPTSAA DDDDDLDLEI DGITLDDNID
910
TTDVNLDDDF LSDD
Length:914
Mass (Da):102,713
Last modified:January 27, 2003 - v2
Checksum:i15E862E1944F5C4B
GO

Sequence cautioni

The sequence AAM50181 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti254R → C in CAA07084 (Ref. 1) Curated1
Sequence conflicti254R → C in CAA07085 (Ref. 1) Curated1
Sequence conflicti343 – 345LPV → CPF in CAA07084 (Ref. 1) Curated3
Sequence conflicti343 – 345LPV → CPF in CAA07085 (Ref. 1) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006523 mRNA Translation: CAA07084.1
AJ006524 Genomic DNA Translation: CAA07085.1
AE014134 Genomic DNA Translation: AAF53294.2
BT023906 mRNA Translation: ABA81840.1
AY119527 mRNA Translation: AAM50181.1 Different initiation.
RefSeqiNP_524836.2, NM_080097.4
UniGeneiDm.2980

Genome annotation databases

EnsemblMetazoaiFBtr0080469; FBpp0080048; FBgn0025724
GeneIDi45757
KEGGidme:Dmel_CG6699

Similar proteinsi

Entry informationi

Entry nameiCOPB2_DROME
AccessioniPrimary (citable) accession number: O62621
Secondary accession number(s): Q3KN33, Q8MRM3, Q9VJZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 27, 2003
Last modified: May 23, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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