Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O62584

- TYS1_ENCCU

UniProt

O62584 - TYS1_ENCCU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Thymidylate synthase 1/2

Gene

TS-1

more
Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei174 – 1741By similarity

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. dTMP biosynthetic process Source: InterPro
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase 1/2 (EC:2.1.1.45)
Short name:
TS 1/2
Short name:
TSase 1/2
Gene namesi
Name:TS-1
Ordered Locus Names:ECU01_0180
AND
Name:TS-2
Ordered Locus Names:ECU01_1430
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Thymidylate synthase 1/2PRO_0000140906Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU01_1430.

Structurei

Secondary structure

1
294
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 2214
Beta strandi24 – 263
Beta strandi34 – 4512
Helixi47 – 493
Beta strandi55 – 573
Helixi61 – 7212
Helixi79 – 824
Turni83 – 853
Helixi114 – 1196
Beta strandi135 – 1373
Helixi139 – 14911
Beta strandi157 – 1593
Helixi166 – 1705
Beta strandi174 – 18310
Beta strandi186 – 19712
Turni198 – 2003
Helixi201 – 21919
Beta strandi223 – 23715
Helixi238 – 2403
Helixi241 – 2477
Beta strandi257 – 2604
Helixi269 – 2713
Helixi274 – 2763
Beta strandi277 – 2815

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KGBX-ray2.20A1-294[»]
ProteinModelPortaliO62584.
SMRiO62584. Positions 6-290.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO62584.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family.Curated

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
InParanoidiO62584.
KOiK00560.
OMAiKWARSKE.
OrthoDBiEOG7X6M9G.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62584-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPQDPRHPEH QYLDLVKHIL ENGARRMDRT GTGTLSVFGA TMRFSLEDNT
60 70 80 90 100
FPLLTTRRVF YRGVVEELLF FLRGETDSKV LEKKGVRIWE KNGAKQFLQS
110 120 130 140 150
VGIDREEGDL GPIYGFQWRH FGARYETSAS SYEGKGVDQI ASAIAAIRAN
160 170 180 190 200
PASRRIVVSA WNPTDLGSMA LPPCHVLFQF NVTDGKLSCA MYQRSGDMGL
210 220 230 240 250
GVPFNIASYS LLTILVAHLT GLQPGEFVHF LGDAHVYLDH VDSLRQQIQR
260 270 280 290
PPRAFPKLFV SPKGPRTEPE HFQYEDFELV GYDPHPAIKM NMSA
Length:294
Mass (Da):33,112
Last modified:August 31, 2004 - v2
Checksum:i5FF3C707E86C0C56
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341T → A in CAA06648. (PubMed:11157783)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005644 Genomic DNA. Translation: CAA06648.1.
AL391737 Genomic DNA. Translation: CAD24888.1.
AL391737 Genomic DNA. Translation: CAD25016.1.
RefSeqiXP_965853.1. XM_960760.1.
XP_965981.1. XM_960888.1.

Genome annotation databases

GeneIDi860190.
860191.
KEGGiecu:ECU01_0180.
ecu:ECU01_1430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005644 Genomic DNA. Translation: CAA06648.1 .
AL391737 Genomic DNA. Translation: CAD24888.1 .
AL391737 Genomic DNA. Translation: CAD25016.1 .
RefSeqi XP_965853.1. XM_960760.1.
XP_965981.1. XM_960888.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KGB X-ray 2.20 A 1-294 [» ]
ProteinModelPortali O62584.
SMRi O62584. Positions 6-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU01_1430.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 860190.
860191.
KEGGi ecu:ECU01_0180.
ecu:ECU01_1430.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
InParanoidi O62584.
KOi K00560.
OMAi KWARSKE.
OrthoDBi EOG7X6M9G.

Enzyme and pathway databases

UniPathwayi UPA00575 .

Miscellaneous databases

EvolutionaryTracei O62584.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "First report on the systematic sequencing of the small genome of Encephalitozoon cuniculi (Protozoa, Microspora): gene organization of a 4.3 kbp region on chromosome I."
    Duffieux F., Peyret P., Roe B.A., Vivares C.P.
    Microb. Comp. Genomics 3:1-11(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora)."
    Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M., Weissenbach J., Saurin W., Vivares C.P.
    Genome Res. 11:198-207(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.

Entry informationi

Entry nameiTYS1_ENCCU
AccessioniPrimary (citable) accession number: O62584
Secondary accession number(s): Q8SQI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 31, 2004
Last modified: October 29, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3