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Protein

Protein kinase C

Gene
N/A
Organism
Suberites domuncula (Sponge)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei372ATPUniRule annotation1
Active sitei467Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi349 – 357ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotationImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase CUniRule annotationSAAS annotation (EC:2.7.11.13UniRule annotationSAAS annotation)
OrganismiSuberites domuncula (Sponge)Imported
Taxonomic identifieri55567 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPoriferaDemospongiaeHeteroscleromorphaSuberitidaSuberitidaeSuberites

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliO62567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 77Phorbol-ester/DAG-typeInterPro annotationAdd BLAST52
Domaini90 – 140Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini166 – 256C2InterPro annotationAdd BLAST91
Domaini343 – 602Protein kinaseInterPro annotationAdd BLAST260
Domaini603 – 673AGC-kinase C-terminalInterPro annotationAdd BLAST71

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.UniRule annotationSAAS annotation
Contains 1 C2 domain.UniRule annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Family and domain databases

CDDicd00029. C1. 2 hits.
Gene3Di2.60.40.150. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014375. Protein_kinase_C_a/b/g.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00168. C2. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000550. PKC_alpha. 1 hit.
PRINTSiPR00360. C2DOMAIN.
PR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00239. C2. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50004. C2. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSGQVRRP KRRNAVRQRQ VVEIRGHKFV LNYFKQFTFC GHCTRFLWGV
60 70 80 90 100
TGPQGYKCLL CDLAIHRRCM EYVSFICPGT SLPEGIEPRP HKFRATTYHT
110 120 130 140 150
PTWCDHCGSL LYGIIRQGVQ CSDCGINVHH RCKGLVPKTC GLGQSEKRGR
160 170 180 190 200
IKVTFSTLQL DDAHIRVNIM IHECRNLPPM DANGLADPYV KLRLYPEPTD
210 220 230 240 250
TPNIKQKTER KEKTLEPKFE EDFFYDVNMN HLDTFLVIEV WDWDKFTAND
260 270 280 290 300
YVGGFALRIG EIIELTKMEP HSSWYKLLDE KRSKTHHERI LADEEATKLI
310 320 330 340 350
EEFRKATILD KAKNLVTDVP IMRRGSELVP GAKDMPKMKL EDFNLLVVLG
360 370 380 390 400
KGSFGKVFLA EQKTTKDVYA IKSLKKDLIV QEDDVECTLN ERKVLALQEK
410 420 430 440 450
PPFLTGLHSC FQTRDHLFFV MEYINGGDLM FHILELGRFP ENQTKFYAGE
460 470 480 490 500
IVLGLRFLHK RGIIYRDLKL DNVMLDADGH IKIADFGLCK EGILGGNKTR
510 520 530 540 550
TFCGTPDYIA PEIISYQPYD AAVDWWALGV LTYEMLVGRP PFDGDDDDQL
560 570 580 590 600
FNNIMEKPVH YPRGMSDPAK KIIQGFLTKH PSRRLGCHPE TGEQDIKGAP
610 620 630 640 650
FFKSIDWDRL GRRELKPPYK PKIRGKKSVS NFDPEFTKEP CRLSPVDPTV
660 670
IGAIEPEVFE GFSFTNPEMY HEP
Length:673
Mass (Da):77,344
Last modified:August 1, 1998 - v1
Checksum:i86D24E554977C293
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13099 mRNA. Translation: CAA73553.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13099 mRNA. Translation: CAA73553.1.

3D structure databases

ProteinModelPortaliO62567.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00029. C1. 2 hits.
Gene3Di2.60.40.150. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000008. C2_dom.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014375. Protein_kinase_C_a/b/g.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00168. C2. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000550. PKC_alpha. 1 hit.
PRINTSiPR00360. C2DOMAIN.
PR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00239. C2. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50004. C2. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO62567_SUBDO
AccessioniPrimary (citable) accession number: O62567
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.