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Protein

Protein kinase C

Gene
N/A
Organism
Suberites domuncula (Sponge)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei372ATPUniRule annotation1
Active sitei467Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi349 – 357ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase CUniRule annotationSAAS annotation (EC:2.7.11.13UniRule annotationSAAS annotation)
OrganismiSuberites domuncula (Sponge)Imported
Taxonomic identifieri55567 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPoriferaDemospongiaeHeteroscleromorphaSuberitidaSuberitidaeSuberites

Subcellular locationi

Structurei

3D structure databases

ProteinModelPortaliO62567
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 77Phorbol-ester/DAG-typeInterPro annotationAdd BLAST52
Domaini90 – 140Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini166 – 256C2InterPro annotationAdd BLAST91
Domaini343 – 602Protein kinaseInterPro annotationAdd BLAST260
Domaini603 – 673AGC-kinase C-terminalInterPro annotationAdd BLAST71

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerSAAS annotation

Family and domain databases

CDDicd00029 C1, 2 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR020454 DAG/PE-bd
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR014375 Protein_kinase_C_a/b/g
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00168 C2, 1 hit
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000550 PKC_alpha, 1 hit
PRINTSiPR00360 C2DOMAIN
PR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00239 C2, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50004 C2, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

O62567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSGQVRRP KRRNAVRQRQ VVEIRGHKFV LNYFKQFTFC GHCTRFLWGV
60 70 80 90 100
TGPQGYKCLL CDLAIHRRCM EYVSFICPGT SLPEGIEPRP HKFRATTYHT
110 120 130 140 150
PTWCDHCGSL LYGIIRQGVQ CSDCGINVHH RCKGLVPKTC GLGQSEKRGR
160 170 180 190 200
IKVTFSTLQL DDAHIRVNIM IHECRNLPPM DANGLADPYV KLRLYPEPTD
210 220 230 240 250
TPNIKQKTER KEKTLEPKFE EDFFYDVNMN HLDTFLVIEV WDWDKFTAND
260 270 280 290 300
YVGGFALRIG EIIELTKMEP HSSWYKLLDE KRSKTHHERI LADEEATKLI
310 320 330 340 350
EEFRKATILD KAKNLVTDVP IMRRGSELVP GAKDMPKMKL EDFNLLVVLG
360 370 380 390 400
KGSFGKVFLA EQKTTKDVYA IKSLKKDLIV QEDDVECTLN ERKVLALQEK
410 420 430 440 450
PPFLTGLHSC FQTRDHLFFV MEYINGGDLM FHILELGRFP ENQTKFYAGE
460 470 480 490 500
IVLGLRFLHK RGIIYRDLKL DNVMLDADGH IKIADFGLCK EGILGGNKTR
510 520 530 540 550
TFCGTPDYIA PEIISYQPYD AAVDWWALGV LTYEMLVGRP PFDGDDDDQL
560 570 580 590 600
FNNIMEKPVH YPRGMSDPAK KIIQGFLTKH PSRRLGCHPE TGEQDIKGAP
610 620 630 640 650
FFKSIDWDRL GRRELKPPYK PKIRGKKSVS NFDPEFTKEP CRLSPVDPTV
660 670
IGAIEPEVFE GFSFTNPEMY HEP
Length:673
Mass (Da):77,344
Last modified:August 1, 1998 - v1
Checksum:i86D24E554977C293
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13099 mRNA Translation: CAA73553.1

Similar proteinsi

Entry informationi

Entry nameiO62567_SUBDO
AccessioniPrimary (citable) accession number: O62567
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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