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Protein

Protein hunchback

Gene

hb

Organism
Drosophila yakuba (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Gap class segmentation protein that controls development of head structures.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri241 – 26323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 35025C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri706 – 72823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri734 – 75825C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Gap protein

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein hunchback
Gene namesi
Name:hb
OrganismiDrosophila yakuba (Fruit fly)
Taxonomic identifieri7245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0022824. Dyak\hb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Protein hunchbackPRO_0000046966Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7245.FBpp0269844.

Structurei

3D structure databases

ProteinModelPortaliO62541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi61 – 7010Poly-Gln
Compositional biasi103 – 1097Poly-Gln
Compositional biasi118 – 1236Poly-His
Compositional biasi405 – 4106Poly-Gln
Compositional biasi525 – 5284Poly-Glu
Compositional biasi555 – 56410Poly-Gln
Compositional biasi690 – 6956Poly-Ala

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri241 – 26323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 35025C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri706 – 72823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri734 – 75825C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
OrthoDBiEOG7GQXVC.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR027775. C2H2_Znf_fam.
IPR027742. Hunchback.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PTHR10032:SF201. PTHR10032:SF201. 2 hits.
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNWETTATT NYEQHNAWYN SMFAANIKQE PGHHLDGNSV ASSPRQSPIP
60 70 80 90 100
STNHLEQFLK QQQQQQHQQQ PMDTLCAMTP SPSQNDQNSL QHYDASLQQQ
110 120 130 140 150
LLQQQQYQQH FQAAQQQHHH HHHLMGGFNP LTPPGLPNPM QHFYGGNLRP
160 170 180 190 200
SPQPTPTSAS TVAPVAVATG SSEKLQALTP PMDVTPPKSP AKSSQSNIEP
210 220 230 240 250
EKEHDQMSNS SEDMKYMAES EDDDTNIRMP IYNSHGKMKN YKCKTCGVVA
260 270 280 290 300
ITKVDFWAHT RTHMKPDKIL QCPKCPFVTE FKHHLEYHIR KHKNQKPFQC
310 320 330 340 350
DKCSYTCVNK SMLNSHRKSH SSVYQYRCAD CDYATKYCHS FKLHLRKYGH
360 370 380 390 400
KPGMVLDEDG TPNPSLVIDV YGTRRGPKSK NGGPIASGGS GSGSRKPNVA
410 420 430 440 450
AVAPQQQQSQ PAQPATSQLS AALQGFPLVQ SNSAPPAASP VLPLPASPAK
460 470 480 490 500
SVASVEQTPS LPSPANLLPP LASLLQQNRN MAFFPYWNLN LQMLLAQQQA
510 520 530 540 550
AVLAQLSPRM REQLQQQNQH QSDNEEEEQD DEYERKSVDS AMDLSQGTPV
560 570 580 590 600
KEDDQHQQQQ QPQQPLAMNL KVEEEATPLM SSSNASRRKG RVLKLDTLLQ
610 620 630 640 650
LRSEAMTSPE QLKVPSTPMP TASSPIAGRK PMPEDHCSGT SSADESMETA
660 670 680 690 700
HVAQANTSAS STASSSGNSS NASSNGNSSS NSSSNGTSSA AAAPASGTPA
710 720 730 740 750
AAGAIYECKY CDIFFKDAVL YTIHMGYHSC DDVFKCNMCG EKCDGPVGLF

VHMARNAHS
Length:759
Mass (Da):83,287
Last modified:August 1, 1998 - v1
Checksum:i67D37A252978D065
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005376 Genomic DNA. Translation: CAA06506.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005376 Genomic DNA. Translation: CAA06506.1.

3D structure databases

ProteinModelPortaliO62541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7245.FBpp0269844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0022824. Dyak\hb.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
OrthoDBiEOG7GQXVC.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR027775. C2H2_Znf_fam.
IPR027742. Hunchback.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PTHR10032:SF201. PTHR10032:SF201. 2 hits.
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Microevolutionary divergence pattern of the segmentation gene hunchback in Drosophila."
    Tautz D., Nigro L.
    Mol. Biol. Evol. 15:1403-1411(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHUNB_DROYA
AccessioniPrimary (citable) accession number: O62541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: January 20, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.