hb - Protein hunchback - Drosophila sechellia (Fruit fly)

Functionⁱ

Gap class segmentation protein that controls development of head structures.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	239 – 261	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	268 – 290	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	296 – 318	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	324 – 348	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	704 – 726	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	732 – 756	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

regulation of development, heterochronic Source: InterPro
segmentation Source: UniProtKB-KW
transcription, DNA-templated Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding, Gap protein
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein hunchback
Gene namesⁱ	Name:hb
Organismⁱ	Drosophila sechellia (Fruit fly)
Taxonomic identifierⁱ	7238 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0024403. Dsec\hb.

FlyBaseⁱ

FBgn0024403. Dsec\hb.

Subcellular locationⁱ

Nucleus By similarity

GO - Cellular componentⁱ

nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000046961	1 – 757	Protein hunchbackAdd BLAST		757

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O62538.
SMRⁱ	O62538.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	61 – 68	Poly-Gln	8
Compositional biasⁱ	101 – 107	Poly-Gln	7
Compositional biasⁱ	116 – 121	Poly-His	6
Compositional biasⁱ	403 – 408	Poly-Gln	6
Compositional biasⁱ	554 – 560	Poly-Gln	7

Sequence similaritiesⁱ

Belongs to the hunchback C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	239 – 261	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	268 – 290	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	296 – 318	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	324 – 348	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	704 – 726	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	732 – 756	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DHN.

OrthoDBⁱ

EOG091G0DHN.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR027775. C2H2_Znf_fam_sub. IPR027742. Hunchback. IPR015943. WD40/YVTN_repeat-like_dom. IPR013087. Znf_C2H2_type.
PANTHERⁱ	PTHR10032. PTHR10032. 1 hit. PTHR10032:SF266. PTHR10032:SF266. 1 hit.
SMARTⁱ	View protein in SMART SM00355. ZnF_C2H2. 6 hits.
SUPFAMⁱ	SSF57667. SSF57667. 3 hits.
PROSITEⁱ	View protein in PROSITE PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 2 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

O62538-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQNWETTATT NYEQHNAWYN SMFAANIKQE PGHHLDGNSV ASSPRQSPIP 
        60         70         80         90        100
STNHLEQFLK QQQQHQQQPM DTLCAMTPSP SQNDQNSLQH YDANLQQQLL 
       110        120        130        140        150
QQQQYQQHFQ AAQQQHHHHH HLMGGFNPLT PPGLPNPMQH FYGGNLRPSP 
       160        170        180        190        200
QPTPTSASTI APVAVATGSS EKLQALTPPM DVTPPKSPAK SSQSNIEPEK 
       210        220        230        240        250
EHDQMSNSSE DMKYMAESED DDTNIRMPIY NSHGKMKNYK CKTCGVVAIT 
       260        270        280        290        300
KVDFWAHTRT HMKPDKILQC PKCPFVTEFK HHLEYHIRKH KNQKPFQCDK 
       310        320        330        340        350
CSYTCVNKSM LNSHRKSHSS VYQYRCADCD YATKYCHSFK LHLRKYGHKP 
       360        370        380        390        400
GMVLDEDGTP NPSLVIDVYG TRRGPKSKNG GPIASGGSGS GSRKSNVAAV 
       410        420        430        440        450
APQQQQSQPA QPVATSHLSA ALQGFPLVQS NSAPPAASPV LPLPASPAKS 
       460        470        480        490        500
VASVEQTPSL PSPANLLPPL ASLLQQNRNM AFFPYWNLNL QMLAAQQQAA 
       510        520        530        540        550
VLAQLSPRMR EQLQQQNQQQ SDNEEEDQDD EYERKSVDSA MDLSQGTPVK 
       560        570        580        590        600
EDEQQQQPQQ PLAMNLKVEE EATPLMSSSN ASRRKGRVLK LDTLLQLRSE 
       610        620        630        640        650
AMTSPEQLKV PSTPMPTASS PIAGRKPMPE EHCSGTSSAD ESMERPHVRQ 
       660        670        680        690        700
ANTSASSTAS SSGNSSNASS NSNGNSSSNS SSNGTTSAVA APPSGTPAAA 
       710        720        730        740        750
GAIYECKYCD IFFKDAVLYT IHMGYHSCDD VFKCNMCGEK CDGPVGLFVH 

MARNAHS

Length:757

Mass (Da):83,175

Last modified:August 1, 1998 - v1

Checksum:ⁱ318404E80D295B0E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ005374 Genomic DNA. Translation: CAA06504.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AJ005374 Genomic DNA. Translation: CAA06504.1.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ005374 Genomic DNA. Translation: CAA06504.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AJ005374 Genomic DNA. Translation: CAA06504.1.

3D structure databases

ProteinModelPortalⁱ	O62538.
SMRⁱ	O62538.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0024403. Dsec\hb.

FlyBaseⁱ

FBgn0024403. Dsec\hb.

Phylogenomic databases

Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DHN.

OrthoDBⁱ

EOG091G0DHN.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR027775. C2H2_Znf_fam_sub. IPR027742. Hunchback. IPR015943. WD40/YVTN_repeat-like_dom. IPR013087. Znf_C2H2_type.
PANTHERⁱ	PTHR10032. PTHR10032. 1 hit. PTHR10032:SF266. PTHR10032:SF266. 1 hit.
SMARTⁱ	View protein in SMART SM00355. ZnF_C2H2. 6 hits.
SUPFAMⁱ	SSF57667. SSF57667. 3 hits.
PROSITEⁱ	View protein in PROSITE PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HUNB_DROSE
Accessionⁱ	O62538Primary (citable) accession number: O62538
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	August 1, 1998
	Last modified:	May 10, 2017
	This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Drosophila annotation project

Miscellaneousⁱ

Documents

Drosophila
Drosophila: entries, gene names and cross-references to FlyBase
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB - O62538 (HUNB_DROSE)

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Protein hunchback

hb

Select a section on the left to see content.

Functionⁱ

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Structureⁱ

3D structure databases

Family & Domainsⁱ

Compositional bias

Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Documents

Similar proteinsⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O62538 (HUNB_DROSE)

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Protein hunchback

hb

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ