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Protein

Protein hunchback

Gene

hb

Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Gap class segmentation protein that controls development of head structures.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri239 – 26123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34825C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri704 – 72623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri732 – 75625C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Gap protein

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein hunchback
Gene namesi
Name:hb
OrganismiDrosophila sechellia (Fruit fly)
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0024403. Dsec\hb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Protein hunchbackPRO_0000046961Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO62538.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi61 – 688Poly-Gln
Compositional biasi101 – 1077Poly-Gln
Compositional biasi116 – 1216Poly-His
Compositional biasi403 – 4086Poly-Gln
Compositional biasi554 – 5607Poly-Gln

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri239 – 26123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34825C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri704 – 72623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri732 – 75625C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

OrthoDBiEOG091G0DHN.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR027775. C2H2_Znf_fam.
IPR027742. Hunchback.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PTHR10032:SF201. PTHR10032:SF201. 2 hits.
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62538-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNWETTATT NYEQHNAWYN SMFAANIKQE PGHHLDGNSV ASSPRQSPIP
60 70 80 90 100
STNHLEQFLK QQQQHQQQPM DTLCAMTPSP SQNDQNSLQH YDANLQQQLL
110 120 130 140 150
QQQQYQQHFQ AAQQQHHHHH HLMGGFNPLT PPGLPNPMQH FYGGNLRPSP
160 170 180 190 200
QPTPTSASTI APVAVATGSS EKLQALTPPM DVTPPKSPAK SSQSNIEPEK
210 220 230 240 250
EHDQMSNSSE DMKYMAESED DDTNIRMPIY NSHGKMKNYK CKTCGVVAIT
260 270 280 290 300
KVDFWAHTRT HMKPDKILQC PKCPFVTEFK HHLEYHIRKH KNQKPFQCDK
310 320 330 340 350
CSYTCVNKSM LNSHRKSHSS VYQYRCADCD YATKYCHSFK LHLRKYGHKP
360 370 380 390 400
GMVLDEDGTP NPSLVIDVYG TRRGPKSKNG GPIASGGSGS GSRKSNVAAV
410 420 430 440 450
APQQQQSQPA QPVATSHLSA ALQGFPLVQS NSAPPAASPV LPLPASPAKS
460 470 480 490 500
VASVEQTPSL PSPANLLPPL ASLLQQNRNM AFFPYWNLNL QMLAAQQQAA
510 520 530 540 550
VLAQLSPRMR EQLQQQNQQQ SDNEEEDQDD EYERKSVDSA MDLSQGTPVK
560 570 580 590 600
EDEQQQQPQQ PLAMNLKVEE EATPLMSSSN ASRRKGRVLK LDTLLQLRSE
610 620 630 640 650
AMTSPEQLKV PSTPMPTASS PIAGRKPMPE EHCSGTSSAD ESMERPHVRQ
660 670 680 690 700
ANTSASSTAS SSGNSSNASS NSNGNSSSNS SSNGTTSAVA APPSGTPAAA
710 720 730 740 750
GAIYECKYCD IFFKDAVLYT IHMGYHSCDD VFKCNMCGEK CDGPVGLFVH

MARNAHS
Length:757
Mass (Da):83,175
Last modified:August 1, 1998 - v1
Checksum:i318404E80D295B0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005374 Genomic DNA. Translation: CAA06504.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005374 Genomic DNA. Translation: CAA06504.1.

3D structure databases

ProteinModelPortaliO62538.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0024403. Dsec\hb.

Phylogenomic databases

OrthoDBiEOG091G0DHN.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR027775. C2H2_Znf_fam.
IPR027742. Hunchback.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PTHR10032:SF201. PTHR10032:SF201. 2 hits.
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHUNB_DROSE
AccessioniPrimary (citable) accession number: O62538
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.