UniProtKB - O62538 (HUNB_DROSE)
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Protein
Protein hunchback
Gene
hb
Organism
Drosophila sechellia (Fruit fly)
Status
Functioni
Gap class segmentation protein that controls development of head structures.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 239 – 261 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 290 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 348 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 704 – 726 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 732 – 756 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II distal enhancer sequence-specific DNA binding Source: EnsemblMetazoa
- transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: EnsemblMetazoa
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: EnsemblMetazoa
- neuroblast fate determination Source: EnsemblMetazoa
- positive regulation of transcription by RNA polymerase II Source: EnsemblMetazoa
- regulation of development, heterochronic Source: InterPro
- regulation of transcription involved in anterior/posterior axis specification Source: EnsemblMetazoa
- terminal region determination Source: EnsemblMetazoa
- torso signaling pathway Source: EnsemblMetazoa
Keywordsi
Molecular function | Developmental protein, DNA-binding, Gap protein |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Protein hunchback |
Gene namesi | Name:hb |
Organismi | Drosophila sechellia (Fruit fly) |
Taxonomic identifieri | 7238 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Organism-specific databases
FlyBasei | FBgn0024403. Dsec\hb. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046961 | 1 – 757 | Protein hunchbackAdd BLAST | 757 |
Structurei
3D structure databases
ProteinModelPortali | O62538. |
SMRi | O62538. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 61 – 68 | Poly-Gln | 8 | |
Compositional biasi | 101 – 107 | Poly-Gln | 7 | |
Compositional biasi | 116 – 121 | Poly-His | 6 | |
Compositional biasi | 403 – 408 | Poly-Gln | 6 | |
Compositional biasi | 554 – 560 | Poly-Gln | 7 |
Sequence similaritiesi
Belongs to the hunchback C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 239 – 261 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 290 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 348 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 704 – 726 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 732 – 756 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
OrthoDBi | EOG091G0DHN. |
Family and domain databases
InterProi | View protein in InterPro IPR027742. Hunchback. IPR036236. Znf_C2H2_sf. IPR013087. Znf_C2H2_type. |
PANTHERi | PTHR24392:SF23. PTHR24392:SF23. 1 hit. |
SMARTi | View protein in SMART SM00355. ZnF_C2H2. 6 hits. |
SUPFAMi | SSF57667. SSF57667. 3 hits. |
PROSITEi | View protein in PROSITE PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 2 hits. |
i Sequence
Sequence statusi: Complete.
O62538-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQNWETTATT NYEQHNAWYN SMFAANIKQE PGHHLDGNSV ASSPRQSPIP
60 70 80 90 100
STNHLEQFLK QQQQHQQQPM DTLCAMTPSP SQNDQNSLQH YDANLQQQLL
110 120 130 140 150
QQQQYQQHFQ AAQQQHHHHH HLMGGFNPLT PPGLPNPMQH FYGGNLRPSP
160 170 180 190 200
QPTPTSASTI APVAVATGSS EKLQALTPPM DVTPPKSPAK SSQSNIEPEK
210 220 230 240 250
EHDQMSNSSE DMKYMAESED DDTNIRMPIY NSHGKMKNYK CKTCGVVAIT
260 270 280 290 300
KVDFWAHTRT HMKPDKILQC PKCPFVTEFK HHLEYHIRKH KNQKPFQCDK
310 320 330 340 350
CSYTCVNKSM LNSHRKSHSS VYQYRCADCD YATKYCHSFK LHLRKYGHKP
360 370 380 390 400
GMVLDEDGTP NPSLVIDVYG TRRGPKSKNG GPIASGGSGS GSRKSNVAAV
410 420 430 440 450
APQQQQSQPA QPVATSHLSA ALQGFPLVQS NSAPPAASPV LPLPASPAKS
460 470 480 490 500
VASVEQTPSL PSPANLLPPL ASLLQQNRNM AFFPYWNLNL QMLAAQQQAA
510 520 530 540 550
VLAQLSPRMR EQLQQQNQQQ SDNEEEDQDD EYERKSVDSA MDLSQGTPVK
560 570 580 590 600
EDEQQQQPQQ PLAMNLKVEE EATPLMSSSN ASRRKGRVLK LDTLLQLRSE
610 620 630 640 650
AMTSPEQLKV PSTPMPTASS PIAGRKPMPE EHCSGTSSAD ESMERPHVRQ
660 670 680 690 700
ANTSASSTAS SSGNSSNASS NSNGNSSSNS SSNGTTSAVA APPSGTPAAA
710 720 730 740 750
GAIYECKYCD IFFKDAVLYT IHMGYHSCDD VFKCNMCGEK CDGPVGLFVH
MARNAHS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ005374 Genomic DNA. Translation: CAA06504.1. |
Similar proteinsi
Entry informationi
Entry namei | HUNB_DROSE | |
Accessioni | O62538Primary (citable) accession number: O62538 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | August 1, 1998 | |
Last modified: | March 28, 2018 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |