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Protein

Protein hunchback

Gene

hb

Organism
Drosophila orena (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Gap class segmentation protein that controls development of head structures.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri242 – 26423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 35125C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri714 – 73623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri742 – 76625C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Gap protein

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein hunchback
Gene namesi
Name:hb
OrganismiDrosophila orena (Fruit fly)
Taxonomic identifieri7233 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0024421. Dore\hb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 767767Protein hunchbackPRO_0000046959Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO62537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi61 – 7111Poly-GlnAdd
BLAST
Compositional biasi104 – 1107Poly-Gln
Compositional biasi119 – 1246Poly-His
Compositional biasi410 – 4156Poly-Gln
Compositional biasi530 – 5334Poly-Glu
Compositional biasi686 – 6938Poly-Ser
Compositional biasi698 – 7014Poly-Ala

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri242 – 26423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 35125C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri714 – 73623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri742 – 76625C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR027775. C2H2_Znf_fam.
IPR027742. Hunchback.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PTHR10032:SF201. PTHR10032:SF201. 2 hits.
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62537-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNWETTATT NYEQHNAWYN SMFAANIKQE PGHHLDGNSV ASSPRQSPIP
60 70 80 90 100
STNHLEQFLK QQQQQHQHQQ QPMDTLCAMT PSPSQNDQNS LQHYDANLQQ
110 120 130 140 150
QLLQQQQYQQ HFQAAQQQHH HHHHLMGGFN PLTPPGLPNP MQHFYGGNLR
160 170 180 190 200
PSPQPTPISA STVASVAVAT GSSEKLQALT PPMDVTPPKS PAKSSQSNIE
210 220 230 240 250
PEKEHDQMSN SSEDMKYMVE SEDDDTNIRM PIYNSHGKMK NYKCKTCGVV
260 270 280 290 300
AITKVDFWAH TRTHMKPDKI LQCPKCPFVT EFKHHLEYHI RKHKNQKPFQ
310 320 330 340 350
CDKCSYTCVN KSMLNSHRKS HSSVYQYRCA DCDYATKYCH SFKLHLRKYG
360 370 380 390 400
HKPGMVLDED GTPNPSLVID VYGTRRGPKS KNGGPIASGG SGSGSGSGSR
410 420 430 440 450
KSNVAAVAPQ QQQTQPTQPP TSQLSAALQG FPLVQSNSAP PAASPLLPLP
460 470 480 490 500
VSPAKSVASV EQTPSLPSPA NLLPPLASLL QQNHNMAFFP YWNLNLQMLA
510 520 530 540 550
AQQQAAVLAQ LSPRMREQLQ QQNQQQSDNE EEEQDDEYER KSVDSAMDLS
560 570 580 590 600
QGTPVKEEEQ QQLHQQQPQQ PLVMNLKVEE EATPLVSSSN ASRRKGRVLK
610 620 630 640 650
LDTLLQLRSG VMTSPEQLKV PSTPMPTASS PIAGRKPMPE DHCSGTSSAD
660 670 680 690 700
ESMETAHVRQ ANTSASSTAS SSGNSSNASS NSNGNSSSNS SSSGTNSAAA
710 720 730 740 750
APPSGTPAAA GAIYECKYCD IFFKDAVLYT IHMGYHSCDD VFKCNMCGEK
760
CDGPVGLFVH MARNAHS
Length:767
Mass (Da):84,207
Last modified:August 1, 1998 - v1
Checksum:i9C7710B7AFD78814
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005375 Genomic DNA. Translation: CAA06505.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005375 Genomic DNA. Translation: CAA06505.1.

3D structure databases

ProteinModelPortaliO62537.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0024421. Dore\hb.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR027775. C2H2_Znf_fam.
IPR027742. Hunchback.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PTHR10032:SF201. PTHR10032:SF201. 2 hits.
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHUNB_DROOR
AccessioniPrimary (citable) accession number: O62537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: January 20, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.