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Protein
Submitted name:

Adaptor protein complex 1, mu subunit

Gene

AP-1mu

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • clathrin binding Source: FlyBase
  • protein transporter activity Source: FlyBase

GO - Biological processi

  • compound eye development Source: FlyBase
  • intracellular protein transport Source: InterPro
  • intracellular transport Source: FlyBase
  • negative regulation of endocytic recycling Source: FlyBase
  • negative regulation of Notch signaling pathway Source: FlyBase
  • secretory granule organization Source: FlyBase
  • vesicle-mediated transport Source: FlyBase

Keywordsi

Biological processProtein transportSAAS annotation, Transport

Enzyme and pathway databases

ReactomeiR-DME-432720 Lysosome Vesicle Biogenesis
R-DME-432722 Golgi Associated Vesicle Biogenesis
R-DME-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Submitted name:
Adaptor protein complex 1, mu subunitImported
Submitted name:
Clathrin-associated adaptor complex AP-1 medium chainImported
Submitted name:
Clathrin-associated proteinImported
Submitted name:
LD31377pImported
Gene namesi
Name:AP-1muImported
Synonyms:AP-1mu1Imported, AP-47Imported, ap-47Imported, AP1mu1Imported, AP47Imported, apm1Imported, APmu1Imported, Dmel\CG9388Imported, Dmu1Imported, mu1Imported
ORF Names:CG9388Imported, Dmel_CG9388Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0024833 AP-1mu

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneSAAS annotation

Expressioni

Gene expression databases

BgeeiFBgn0024833

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiO62531, 5 interactors
STRINGi7227.FBpp0081592

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 424MHDInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the adaptor complexes medium subunit family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0937 Eukaryota
ENOG410XPFS LUCA
KOiK12393
OMAiQQVTPCF
OrthoDBiEOG091G06XI

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR001392 Clathrin_mu
IPR018240 Clathrin_mu_CS
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992 Clathrin_mu, 1 hit
PRINTSiPR00314 CLATHRINADPT
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit

Sequencei

Sequence statusi: Complete.

O62531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSAIFVLD VKGKVLISRN YRGDNIDMAV IDKFMPLLME REEEGLITPI
60 70 80 90 100
LQTAETTFAY IKTNNLYIVS TTPRNKNVNI ALVFVFLHKI AQVFVEYFKE
110 120 130 140 150
LEEESIRDNF VIIYELLDEL LDFGYPQTTD SKILQEYITQ EGHKLELQPR
160 170 180 190 200
IPVAVTNAVS WRSEGIKYRK NEVFLDVIES VNLLANANGN VLRSEIVGAI
210 220 230 240 250
KMRVYLSGMP ELRLGLNDKV LFESTGRGKS KSVELEDVKF HQCVRLSRFE
260 270 280 290 300
NDRTISFIPP DGEFELMSYR LNTHVKPLIW IESVIERHAH SRVEYMIKAK
310 320 330 340 350
SQFKRRSTAN NVEIVIPVPA DADSPKFKTT IGSCKYAPEQ NAIIWTIKSF
360 370 380 390 400
PGGKEYLMRA HFGLPSVESE DNTEGKPPIQ VRFEIPYFTT SGIQVRYLKI
410 420
IEKSGYQALP WVRYITQNGD YQLRTN
Length:426
Mass (Da):48,940
Last modified:August 1, 1998 - v1
Checksum:i921A9E3F1064EA42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110231 mRNA Translation: AAF14247.1
AE014297 Genomic DNA Translation: AAF54399.1
AY058621 mRNA Translation: AAL13850.1
AJ006219 mRNA Translation: CAA06918.1
RefSeqiNP_649906.1, NM_141649.2
UniGeneiDm.1125

Genome annotation databases

EnsemblMetazoaiFBtr0082114; FBpp0081592; FBgn0024833
GeneIDi41150
KEGGidme:Dmel_CG9388
UCSCiCG9388-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiO62531_DROME
AccessioniPrimary (citable) accession number: O62531
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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