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Protein
Submitted name:

Adaptor protein complex 1, mu subunit

Gene

AP-1mu

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • clathrin binding Source: FlyBase
  • protein transporter activity Source: FlyBase

GO - Biological processi

  • compound eye development Source: FlyBase
  • intracellular protein transport Source: InterPro
  • intracellular transport Source: FlyBase
  • negative regulation of endocytic recycling Source: FlyBase
  • negative regulation of Notch signaling pathway Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
  • secretory granule organization Source: FlyBase
  • synaptic vesicle coating Source: FlyBase
  • vesicle coating Source: FlyBase
  • vesicle-mediated transport Source: FlyBase

Keywordsi

Biological processProtein transportSAAS annotation, Transport

Enzyme and pathway databases

ReactomeiR-DME-432720. Lysosome Vesicle Biogenesis.
R-DME-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
Adaptor protein complex 1, mu subunitImported
Submitted name:
Clathrin-associated adaptor complex AP-1 medium chainImported
Submitted name:
Clathrin-associated proteinImported
Submitted name:
LD31377pImported
Gene namesi
Name:AP-1muImported
Synonyms:AP-47Imported, AP47Imported
ORF Names:CG9388Imported, Dmel_CG9388Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0024833. AP-1mu.

Subcellular locationi

GO - Cellular componenti

  • AP-1 adaptor complex Source: FlyBase
  • clathrin-coated vesicle Source: FlyBase
  • coated vesicle Source: FlyBase
  • synaptic vesicle Source: FlyBase
  • transcription factor AP-1 complex Source: FlyBase

Expressioni

Gene expression databases

BgeeiFBgn0024833.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7227.FBpp0081592.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 424MHD (mu homology)InterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the adaptor complexes medium subunit family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0937. Eukaryota.
ENOG410XPFS. LUCA.
KOiK12393.
OMAiQQVTPCF.
OrthoDBiEOG091G06XI.

Family and domain databases

InterProiView protein in InterPro
IPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
PfamiView protein in Pfam
PF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiView protein in PROSITE
PS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.

Sequencei

Sequence statusi: Complete.

O62531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSAIFVLD VKGKVLISRN YRGDNIDMAV IDKFMPLLME REEEGLITPI
60 70 80 90 100
LQTAETTFAY IKTNNLYIVS TTPRNKNVNI ALVFVFLHKI AQVFVEYFKE
110 120 130 140 150
LEEESIRDNF VIIYELLDEL LDFGYPQTTD SKILQEYITQ EGHKLELQPR
160 170 180 190 200
IPVAVTNAVS WRSEGIKYRK NEVFLDVIES VNLLANANGN VLRSEIVGAI
210 220 230 240 250
KMRVYLSGMP ELRLGLNDKV LFESTGRGKS KSVELEDVKF HQCVRLSRFE
260 270 280 290 300
NDRTISFIPP DGEFELMSYR LNTHVKPLIW IESVIERHAH SRVEYMIKAK
310 320 330 340 350
SQFKRRSTAN NVEIVIPVPA DADSPKFKTT IGSCKYAPEQ NAIIWTIKSF
360 370 380 390 400
PGGKEYLMRA HFGLPSVESE DNTEGKPPIQ VRFEIPYFTT SGIQVRYLKI
410 420
IEKSGYQALP WVRYITQNGD YQLRTN
Length:426
Mass (Da):48,940
Last modified:August 1, 1998 - v1
Checksum:i921A9E3F1064EA42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110231 mRNA. Translation: AAF14247.1.
AE014297 Genomic DNA. Translation: AAF54399.1.
AY058621 mRNA. Translation: AAL13850.1.
AJ006219 mRNA. Translation: CAA06918.1.
RefSeqiNP_649906.1. NM_141649.2.
UniGeneiDm.1125.

Genome annotation databases

EnsemblMetazoaiFBtr0082114; FBpp0081592; FBgn0024833.
GeneIDi41150.
KEGGidme:Dmel_CG9388.
UCSCiCG9388-RA. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiO62531_DROME
AccessioniPrimary (citable) accession number: O62531
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: July 5, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported