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Protein
Submitted name:

Adaptor protein complex 1, mu subunit

Gene

AP-1mu

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • clathrin binding Source: FlyBase
  • protein transporter activity Source: FlyBase

GO - Biological processi

  • compound eye development Source: FlyBase
  • intracellular protein transport Source: InterPro
  • intracellular transport Source: FlyBase
  • negative regulation of endocytic recycling Source: FlyBase
  • negative regulation of Notch signaling pathway Source: FlyBase
  • secretory granule organization Source: FlyBase
  • vesicle-mediated transport Source: FlyBase

Keywordsi

Biological processProtein transportSAAS annotation, Transport

Enzyme and pathway databases

ReactomeiR-DME-432720. Lysosome Vesicle Biogenesis.
R-DME-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
Adaptor protein complex 1, mu subunitImported
Submitted name:
Clathrin-associated adaptor complex AP-1 medium chainImported
Submitted name:
Clathrin-associated proteinImported
Submitted name:
LD31377pImported
Gene namesi
Name:AP-1muImported
Synonyms:AP-1mu1Imported, AP-47Imported, ap-47Imported, AP1mu1Imported, AP47Imported, apm1Imported, APmu1Imported, CG9388Imported, Dmel\CG9388Imported, Dmu1Imported, mu1Imported
ORF Names:Dmel_CG9388Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0024833. AP-1mu.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0024833.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiO62531. 5 interactors.
STRINGi7227.FBpp0081592.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 424MHDInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the adaptor complexes medium subunit family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0937. Eukaryota.
ENOG410XPFS. LUCA.
KOiK12393.
OMAiQQVTPCF.
OrthoDBiEOG091G06XI.

Family and domain databases

InterProiView protein in InterPro
IPR036168. AP2_Mu_C_sf.
IPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
PfamiView protein in Pfam
PF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiView protein in PROSITE
PS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.

Sequencei

Sequence statusi: Complete.

O62531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSAIFVLD VKGKVLISRN YRGDNIDMAV IDKFMPLLME REEEGLITPI
60 70 80 90 100
LQTAETTFAY IKTNNLYIVS TTPRNKNVNI ALVFVFLHKI AQVFVEYFKE
110 120 130 140 150
LEEESIRDNF VIIYELLDEL LDFGYPQTTD SKILQEYITQ EGHKLELQPR
160 170 180 190 200
IPVAVTNAVS WRSEGIKYRK NEVFLDVIES VNLLANANGN VLRSEIVGAI
210 220 230 240 250
KMRVYLSGMP ELRLGLNDKV LFESTGRGKS KSVELEDVKF HQCVRLSRFE
260 270 280 290 300
NDRTISFIPP DGEFELMSYR LNTHVKPLIW IESVIERHAH SRVEYMIKAK
310 320 330 340 350
SQFKRRSTAN NVEIVIPVPA DADSPKFKTT IGSCKYAPEQ NAIIWTIKSF
360 370 380 390 400
PGGKEYLMRA HFGLPSVESE DNTEGKPPIQ VRFEIPYFTT SGIQVRYLKI
410 420
IEKSGYQALP WVRYITQNGD YQLRTN
Length:426
Mass (Da):48,940
Last modified:August 1, 1998 - v1
Checksum:i921A9E3F1064EA42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110231 mRNA. Translation: AAF14247.1.
AE014297 Genomic DNA. Translation: AAF54399.1.
AY058621 mRNA. Translation: AAL13850.1.
AJ006219 mRNA. Translation: CAA06918.1.
RefSeqiNP_649906.1. NM_141649.2.
UniGeneiDm.1125.

Genome annotation databases

EnsemblMetazoaiFBtr0082114; FBpp0081592; FBgn0024833.
GeneIDi41150.
KEGGidme:Dmel_CG9388.
UCSCiCG9388-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiO62531_DROME
AccessioniPrimary (citable) accession number: O62531
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported