Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Adaptor protein complex 2, mu subunit, isoform A

Gene

AP-2mu

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei343 – 3431Phosphatidylinositol lipid headgroupUniRule annotation
Binding sitei345 – 3451Phosphatidylinositol lipid headgroupUniRule annotation
Binding sitei347 – 3471Phosphatidylinositol lipid headgroupUniRule annotation
Binding sitei356 – 3561Phosphatidylinositol lipid headgroupUniRule annotation
Binding sitei358 – 3581Phosphatidylinositol lipid headgroupUniRule annotation

GO - Molecular functioni

  • lipid binding Source: UniProtKB-KW
  • protein transporter activity Source: FlyBase

GO - Biological processi

  • dsRNA transport Source: FlyBase
  • endocytosis Source: FlyBase
  • epithelium development Source: FlyBase
  • germarium-derived egg chamber formation Source: FlyBase
  • intracellular protein transport Source: InterPro
  • neurotransmitter secretion Source: FlyBase
  • synaptic vesicle coating Source: FlyBase
  • vesicle coating Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Protein transportSAAS annotation, Transport

Keywords - Ligandi

Lipid-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-177504. Retrograde neurotrophin signalling.
R-DME-182971. EGFR downregulation.
R-DME-190873. Gap junction degradation.
R-DME-196025. Formation of annular gap junctions.
R-DME-3928665. EPH-ephrin mediated repulsion of cells.
R-DME-416993. Trafficking of GluR2-containing AMPA receptors.
R-DME-437239. Recycling pathway of L1.
R-DME-5099900. WNT5A-dependent internalization of FZD4.

Names & Taxonomyi

Protein namesi
Submitted name:
Adaptor protein complex 2, mu subunit, isoform AImported
Submitted name:
Adaptor protein complex 2, mu subunit, isoform BImported
Submitted name:
Adaptor protein complex 2, mu subunit, isoform CImported
Submitted name:
Clathrin-associated adaptor complex AP-2 medium chainImported
Submitted name:
Clathrin-associated proteinImported
Submitted name:
SD05403pImported
Gene namesi
Name:AP-2muImported
Synonyms:AP-50Imported, AP50Imported
ORF Names:CG7057Imported, Dmel_CG7057Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0263351. AP-2mu.

Subcellular locationi

GO - Cellular componenti

  • AP-2 adaptor complex Source: FlyBase
  • coated vesicle Source: FlyBase
  • synaptic vesicle Source: FlyBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

MINTiMINT-282896.
STRINGi7227.FBpp0083646.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 436269MHD (mu homology)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adaptor complexes medium subunit family.SAAS annotation
Contains MHD (mu homology) domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0937. Eukaryota.
ENOG410XPFS. LUCA.
GeneTreeiENSGT00530000062779.
KOiK11826.
OMAiVWKIPRI.
OrthoDBiEOG72RMXV.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62530-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGGLFVYNH KGEVLISRVY RDDIGRNAVD AFRVNVIHAR QQVRSPVTNI
60 70 80 90 100
ARTSFFHIKR ANIWLAAVTK QNVNAAMVFE FLLKIIEVMQ SYFGKISEEN
110 120 130 140 150
IKNNFVLIYE LLDEILDFGY PQNTDSGTLK TFITQQGIKS ATKEEQMQIT
160 170 180 190 200
SQVTGQIGWR REGIKYRRNE LFLDVLEYVN LLMSPQGQVL SAHVAGKVVM
210 220 230 240 250
KSYLSGMPEC KFGINDKIVM ESKGRGLSGN SEAETSRSGK PVVVIDDCQF
260 270 280 290 300
HQCVKLSKFE TEHSISFIPP DGEFELMRYR TTKDISLPFR VIPLVREVGR
310 320 330 340 350
TKMEVKVVLK SNFKPSLLGQ KIEVKIPTPL NTSGVQLICL KGKAKYKASE
360 370 380 390 400
NAIVWKIKRM AGMKETQLSA EIELLETDTK KKWTRPPISM NFEVPFAPSG
410 420 430
FKVRYLKVFE PKLNYSDHDV VKWVRYIGRS GLYETRC
Length:437
Mass (Da):49,856
Last modified:August 1, 1998 - v1
Checksum:i56FACB065A6A7D10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110232 mRNA. Translation: AAF14248.1.
AE014297 Genomic DNA. Translation: AAF56001.1.
AE014297 Genomic DNA. Translation: AAF56002.3.
AY070712 mRNA. Translation: AAL48183.1.
AE014297 Genomic DNA. Translation: ACZ94982.1.
AJ005962 Genomic DNA. Translation: CAA06785.1.
RefSeqiNP_001163686.1. NM_001170215.2.
NP_651049.3. NM_142792.5.
NP_732744.1. NM_170015.3.
UniGeneiDm.3043.

Genome annotation databases

EnsemblMetazoaiFBtr0084252; FBpp0083645; FBgn0263351.
FBtr0084253; FBpp0083646; FBgn0263351.
FBtr0301866; FBpp0291080; FBgn0263351.
GeneIDi42642.
KEGGidme:Dmel_CG7057.
UCSCiCG7057-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110232 mRNA. Translation: AAF14248.1.
AE014297 Genomic DNA. Translation: AAF56001.1.
AE014297 Genomic DNA. Translation: AAF56002.3.
AY070712 mRNA. Translation: AAL48183.1.
AE014297 Genomic DNA. Translation: ACZ94982.1.
AJ005962 Genomic DNA. Translation: CAA06785.1.
RefSeqiNP_001163686.1. NM_001170215.2.
NP_651049.3. NM_142792.5.
NP_732744.1. NM_170015.3.
UniGeneiDm.3043.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-282896.
STRINGi7227.FBpp0083646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084252; FBpp0083645; FBgn0263351.
FBtr0084253; FBpp0083646; FBgn0263351.
FBtr0301866; FBpp0291080; FBgn0263351.
GeneIDi42642.
KEGGidme:Dmel_CG7057.
UCSCiCG7057-RA. d. melanogaster.

Organism-specific databases

CTDi42642.
FlyBaseiFBgn0263351. AP-2mu.

Phylogenomic databases

eggNOGiKOG0937. Eukaryota.
ENOG410XPFS. LUCA.
GeneTreeiENSGT00530000062779.
KOiK11826.
OMAiVWKIPRI.
OrthoDBiEOG72RMXV.

Enzyme and pathway databases

ReactomeiR-DME-177504. Retrograde neurotrophin signalling.
R-DME-182971. EGFR downregulation.
R-DME-190873. Gap junction degradation.
R-DME-196025. Formation of annular gap junctions.
R-DME-3928665. EPH-ephrin mediated repulsion of cells.
R-DME-416993. Trafficking of GluR2-containing AMPA receptors.
R-DME-437239. Recycling pathway of L1.
R-DME-5099900. WNT5A-dependent internalization of FZD4.

Miscellaneous databases

GenomeRNAii42642.
NextBioi829834.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, mapping and tissue-specific expression of Drosophila clathrin-associated protein AP50 gene."
    Zhang Y.Q., Broadie K.
    Gene 233:171-179(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Defective expression of the mu3 subunit of the AP-3 adaptor complex in the Drosophila pigmentation mutant carmine."
    Mullins C., Hartnell L.M., Wassarman D.A., Bonifacino J.S.
    Mol. Gen. Genet. 262:401-412(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  7. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  9. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  11. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  14. FlyBase
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO62530_DROME
AccessioniPrimary (citable) accession number: O62530
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.