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Protein
Submitted name:

Rho type GEF

Gene

RtGEF

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • positive regulation of GTPase activity Source: FlyBase
  • positive regulation of hippo signaling Source: FlyBase
  • regulation of organ growth Source: FlyBase
  • regulation of Rho protein signal transduction Source: InterPro
  • regulation of synapse organization Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-182971 EGFR downregulation
R-DME-193648 NRAGE signals death through JNK
R-DME-194840 Rho GTPase cycle
R-DME-3928664 Ephrin signaling
R-DME-416482 G alpha (12/13) signalling events
R-DME-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
SignaLinkiO62527

Names & Taxonomyi

Protein namesi
Submitted name:
Rho type GEFImported
Gene namesi
Name:RtGEFImported
Synonyms:rtGEFImported
ORF Names:CG10043Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0015803 RtGEF

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiO62527

Expressioni

Gene expression databases

BgeeiFBgn0015803
ExpressionAtlasiO62527 differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO62527
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 61SH3InterPro annotationAdd BLAST60
Domaini78 – 252DHInterPro annotationAdd BLAST175
Domaini274 – 375PHInterPro annotationAdd BLAST102

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili641 – 668Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2070 Eukaryota
ENOG410XNNP LUCA
OrthoDBiEOG091G04XA

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

O62527-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQPLVVQAE YSFMGSNNDE LCFQKGDVIT VTQREDGGWW EGTLNDKTGW
60 70 80 90 100
FPSNYVNECK VQLPLTETIR PPEEIQEYRS VVLKDLLDSE RAHVAELQGL
110 120 130 140 150
LENFLEPMQQ TQILSQDEYA QLMCNFVEIV RTHEDLLIQI EECNDRVGKL
160 170 180 190 200
FLTSAPLMKK VHQAYCAAHP KAIVILDKYK DELEKYMERQ GAATPGLLVL
210 220 230 240 250
TTGLSKPFRR LDKYSAMLQE LERHMESSHP DRGDTQRSVA VYKDIAATCS
260 270 280 290 300
ATRRQKELEL QVLTGPVRGW QGQELSTLGD IIHMGSVAVG ADHRDRYFVL
310 320 330 340 350
FPQTLLFLSV SQRMSAFIYE GKLPLTGIIV NRLEDTDALK NAFEISSPLI
360 370 380 390 400
DRIVAVCQGP NEANKWVELL NANNPSLPMG IKRQLSNLSN SSLGHLNAAH
410 420 430 440 450
MSPPSSHILL PAGGRPPATP SSIPAGSSSG GSHSHQGSPA TNSMSHHKRS
460 470 480 490 500
QSFNHHLSYN QYTPTQPPPH HLHPPQPPSL PSHLGASGPR SSSAQTPNSK
510 520 530 540 550
TAAPLQASSM DASPAIQAAA AAAAAAVGMG VPSARKGSTK ANWTISCLRP
560 570 580 590 600
TPPLRPSLLN ATSGSGSGSG GSGGGGSSSS NALASYCSGR KNQPTYEEDA
610 620 630 640 650
LVLRVFEAYC AAYQNNARNT IHSGLENEDM TPTLRQLWTA IRQMQQDMSQ
660 670 680
IKLQINEERA LRADLQQLLM QHLETSSVSS GANTPKC
Length:687
Mass (Da):74,981
Last modified:August 1, 1998 - v1
Checksum:i5BB49865C34C9BB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224676 mRNA Translation: CAA12058.1

Similar proteinsi

Entry informationi

Entry nameiO62527_DROME
AccessioniPrimary (citable) accession number: O62527
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health