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Protein
Submitted name:

Rho type GEF

Gene

RtGEF

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: FlyBase
  • protein complex scaffold Source: FlyBase
  • Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  • positive regulation of GTPase activity Source: FlyBase
  • positive regulation of hippo signaling Source: FlyBase
  • regulation of organ growth Source: FlyBase
  • regulation of Rho protein signal transduction Source: InterPro
  • regulation of synapse organization Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-182971. EGFR downregulation.
R-DME-193648. NRAGE signals death through JNK.
R-DME-194840. Rho GTPase cycle.
R-DME-3928664. Ephrin signaling.
R-DME-416482. G alpha (12/13) signalling events.
R-DME-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.
SignaLinkiO62527.

Names & Taxonomyi

Protein namesi
Submitted name:
Rho type GEFImported
Gene namesi
Name:RtGEFImported
Synonyms:rtGEFImported
ORF Names:CG10043Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0015803. RtGEF.

Subcellular locationi

GO - Cellular componenti

  • muscle cell postsynaptic density Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO62527.
PRIDEiO62527.

Expressioni

Gene expression databases

BgeeiO62527.
ExpressionAtlasiO62527. differential.

Interactioni

GO - Molecular functioni

  • protein complex scaffold Source: FlyBase

Protein-protein interaction databases

STRINGi7227.FBpp0111797.

Structurei

3D structure databases

ProteinModelPortaliO62527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 6160SH3InterPro annotationAdd
BLAST
Domaini78 – 252175DH (DBL-homology)InterPro annotationAdd
BLAST
Domaini274 – 375102PHInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili641 – 66828Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains DH (DBL-homology) domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2070. Eukaryota.
ENOG410XNNP. LUCA.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62527-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQPLVVQAE YSFMGSNNDE LCFQKGDVIT VTQREDGGWW EGTLNDKTGW
60 70 80 90 100
FPSNYVNECK VQLPLTETIR PPEEIQEYRS VVLKDLLDSE RAHVAELQGL
110 120 130 140 150
LENFLEPMQQ TQILSQDEYA QLMCNFVEIV RTHEDLLIQI EECNDRVGKL
160 170 180 190 200
FLTSAPLMKK VHQAYCAAHP KAIVILDKYK DELEKYMERQ GAATPGLLVL
210 220 230 240 250
TTGLSKPFRR LDKYSAMLQE LERHMESSHP DRGDTQRSVA VYKDIAATCS
260 270 280 290 300
ATRRQKELEL QVLTGPVRGW QGQELSTLGD IIHMGSVAVG ADHRDRYFVL
310 320 330 340 350
FPQTLLFLSV SQRMSAFIYE GKLPLTGIIV NRLEDTDALK NAFEISSPLI
360 370 380 390 400
DRIVAVCQGP NEANKWVELL NANNPSLPMG IKRQLSNLSN SSLGHLNAAH
410 420 430 440 450
MSPPSSHILL PAGGRPPATP SSIPAGSSSG GSHSHQGSPA TNSMSHHKRS
460 470 480 490 500
QSFNHHLSYN QYTPTQPPPH HLHPPQPPSL PSHLGASGPR SSSAQTPNSK
510 520 530 540 550
TAAPLQASSM DASPAIQAAA AAAAAAVGMG VPSARKGSTK ANWTISCLRP
560 570 580 590 600
TPPLRPSLLN ATSGSGSGSG GSGGGGSSSS NALASYCSGR KNQPTYEEDA
610 620 630 640 650
LVLRVFEAYC AAYQNNARNT IHSGLENEDM TPTLRQLWTA IRQMQQDMSQ
660 670 680
IKLQINEERA LRADLQQLLM QHLETSSVSS GANTPKC
Length:687
Mass (Da):74,981
Last modified:August 1, 1998 - v1
Checksum:i5BB49865C34C9BB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224676 mRNA. Translation: CAA12058.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224676 mRNA. Translation: CAA12058.1.

3D structure databases

ProteinModelPortaliO62527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0111797.

Proteomic databases

PaxDbiO62527.
PRIDEiO62527.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0015803. RtGEF.

Phylogenomic databases

eggNOGiKOG2070. Eukaryota.
ENOG410XNNP. LUCA.

Enzyme and pathway databases

ReactomeiR-DME-182971. EGFR downregulation.
R-DME-193648. NRAGE signals death through JNK.
R-DME-194840. Rho GTPase cycle.
R-DME-3928664. Ephrin signaling.
R-DME-416482. G alpha (12/13) signalling events.
R-DME-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.
SignaLinkiO62527.

Miscellaneous databases

ChiTaRSirtGEF. fly.

Gene expression databases

BgeeiO62527.
ExpressionAtlasiO62527. differential.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A Drosophila gene with predicted rhoGEF, pleckstrin homology and SH3 domains is highly expressed in morphogenic tissues."
    Werner L.A., Manseau L.J.
    Gene 187:107-114(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Canton SImported.
    Tissue: OvaryImported.
  2. "A Drosophila gene with predicted rhoGEF, pleckstrin homology and SH3 domains is highly expressed in morphogenic tissues."
    Pinter M., Manseau L.J.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Canton SImported.
    Tissue: OvaryImported.

Entry informationi

Entry nameiO62527_DROME
AccessioniPrimary (citable) accession number: O62527
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.