Ant2

Functionⁱ

GO - Molecular functionⁱ

ATP:ADP antiporter activity Source: FlyBase

Complete GO annotation...

GO - Biological processⁱ

ADP transport Source: FlyBase
ATP transport Source: FlyBase
regulation of mitochondrial membrane permeability Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Biological process	TransportUniRule annotationSAAS annotation

Biological process

TransportUniRule annotationSAAS annotation

Enzyme and pathway databases

Reactomeⁱ	R-DME-1268020. Mitochondrial protein import. R-DME-422356. Regulation of insulin secretion.

Reactomeⁱ

R-DME-1268020. Mitochondrial protein import.
R-DME-422356. Regulation of insulin secretion.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: ADP/ATP translocaseImported Submitted name: AT02195pImported Submitted name: AT07206pImported Submitted name: Adenine nucleotide translocase 2, isoform AImported Submitted name: Adenine nucleotide translocase 2, isoform BImported Submitted name: Adenine nucleotide translocase 2, isoform CImported Submitted name: GM13259pImported
Gene namesⁱ	Name:Ant2Imported Synonyms:Ant2-RAImported, Ant2-RBImported ORF Names:CG1683Imported, Dmel_CG1683Imported
Organismⁱ	Drosophila melanogaster (Fruit fly)Imported
Taxonomic identifierⁱ	7227 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › melanogaster group › melanogaster subgroup
Proteomesⁱ	UP000000803 Componentⁱ: Chromosome X

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0025111. Ant2.

FlyBaseⁱ

FBgn0025111. Ant2.

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	181 – 200	HelicalSequence analysisAdd BLAST		20
Transmembraneⁱ	220 – 240	HelicalSequence analysisAdd BLAST		21

GO - Cellular componentⁱ

integral component of membrane Source: GO_Central
mitochondrial inner membrane Source: FlyBase

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

Expressionⁱ

Gene expression databases

Bgeeⁱ	FBgn0025111.

Bgeeⁱ

FBgn0025111.

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	O62526. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-1594074.
STRINGⁱ	7227.FBpp0073282.

Structureⁱ

3D structure databases

SMRⁱ	O62526.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	16 – 108	SolcarPROSITE-ProRule annotationAdd BLAST	93
Repeatⁱ	121 – 210	SolcarPROSITE-ProRule annotationAdd BLAST	90
Repeatⁱ	221 – 306	SolcarPROSITE-ProRule annotationAdd BLAST	86

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domainⁱ

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG0749. Eukaryota. ENOG410XNW0. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011543.
HOGENOMⁱ	HOG000245391.
KEGG Orthology (KO) More...KOⁱ	K05863.
OMAⁱ	QHASKTI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ULB.

Family and domain databases

Gene3Dⁱ	1.50.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR002113. Aden_trnslctor. IPR002067. Mit_carrier. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153. Mito_carr. 3 hits.
PRINTSⁱ	PR00927. ADPTRNSLCASE. PR00926. MITOCARRIER.
SUPFAMⁱ	SSF103506. SSF103506. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50920. SOLCAR. 3 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

O62526-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGDEGGGGGH GKGDLKSFLM DFMMGGVSAA IAKTAVAPIE RVKLILQVQE 
        60         70         80         90        100
VSKQIAADQR YKGIVDCFIR IPKEQGFSSF WRGNLANVIR YFPTQALNFA 
       110        120        130        140        150
FKDVYKSVFL GGVDKHKQFW RHFAGNLASG GAAGATSLCF VYPLDFARTR 
       160        170        180        190        200
LAADVGKGGN REFNGLIDCL MKVIKSDGPI GLYRGFIVSV QGIVIYRAAY 
       210        220        230        240        250
FGFYDTCRDF LPNPKSTPFY VSWAIAQVVT TVAGIASYPF DTVRRRMMMQ 
       260        270        280        290        300
SGLKKSEMVY KNTAHCWLVI AKQEGIGAFF KGALSNIIRG TGGALVLALY 

DEMKKYF

Length:307

Mass (Da):33,744

Last modified:August 1, 1998 - v1

Checksum:ⁱ3D6B3DFD82061C0C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE014298 Genomic DNA. Translation: AAF47956.1. AE014298 Genomic DNA. Translation: AAO41648.1. BT044582 mRNA. Translation: ACI31282.1. BT044583 mRNA. Translation: ACI31283.1. BT088432 mRNA. Translation: ACR40400.1. AE014298 Genomic DNA. Translation: AGB95275.1. Y10618 Genomic DNA. Translation: CAA71629.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001259432.1. NM_001272503.1. NP_511110.1. NM_078555.4. NP_788898.1. NM_176725.3.
UniGeneⁱ	Dm.21507.

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0073425; FBpp0073281; FBgn0025111. FBtr0073426; FBpp0073282; FBgn0025111. FBtr0333963; FBpp0306086; FBgn0025111.
GeneIDⁱ	32008.
KEGGⁱ	dme:Dmel_CG1683.
UCSC genome browser More...UCSCⁱ	CG1683-RA. d. melanogaster.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
O62526	D0QWE9 B4PXZ7 Q29H34 B4H0G0 B3NVE6 B4IDU0 B4N1J9 A0A1W4UPD0 UPI0007E3309B UPI0007E63FE6 +11	Drosophila melanogaster (Fruit fly) Drosophila miranda (Fruit fly) Drosophila yakuba (Fruit fly) Drosophila pseudoobscura pseudoobscura (Fruit fly) Drosophila persimilis (Fruit fly) Drosophila erecta (Fruit fly) Drosophila sechellia (Fruit fly) Drosophila willistoni (Fruit fly) Drosophila ficusphila (Fruit fly) Drosophila suzukii (Spotted-wing drosophila fruit fly) And more	307	UniRef90_O62526	Cluster: ADP/ATP translocase	22

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
O62526	P18239 G2W8X8 A6ZKR7 N1PAX7 A0A0L8RMP0 J8Q7R0 E7K9C4 E7Q0S8 E7NEP1 H0GR24 +288	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557) (Baker's yeast) Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) Saccharomyces eubayanus (Yeast) Saccharomyces arboricola (strain H-6 / AS 2.3317 / CBS 10644) (Yeast) Saccharomyces cerevisiae (strain AWRI796) (Baker's yeast) Saccharomyces cerevisiae (strain FostersB) (Baker's yeast) Saccharomyces cerevisiae (strain FostersO) (Baker's yeast) Saccharomyces cerevisiae x Saccharomyces kudriavzevii (strain VIN7) (Yeast) And more	318	UniRef50_P18239	Cluster: ADP,ATP carrier protein 2	299

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE014298 Genomic DNA. Translation: AAF47956.1. AE014298 Genomic DNA. Translation: AAO41648.1. BT044582 mRNA. Translation: ACI31282.1. BT044583 mRNA. Translation: ACI31283.1. BT088432 mRNA. Translation: ACR40400.1. AE014298 Genomic DNA. Translation: AGB95275.1. Y10618 Genomic DNA. Translation: CAA71629.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001259432.1. NM_001272503.1. NP_511110.1. NM_078555.4. NP_788898.1. NM_176725.3.
UniGeneⁱ	Dm.21507.

3D structure databases

SMRⁱ	O62526.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	O62526. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-1594074.
STRINGⁱ	7227.FBpp0073282.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0073425; FBpp0073281; FBgn0025111. FBtr0073426; FBpp0073282; FBgn0025111. FBtr0333963; FBpp0306086; FBgn0025111.
GeneIDⁱ	32008.
KEGGⁱ	dme:Dmel_CG1683.
UCSC genome browser More...UCSCⁱ	CG1683-RA. d. melanogaster.

Organism-specific databases

CTDⁱ	32008.
Drosophila genome database More...FlyBaseⁱ	FBgn0025111. Ant2.

Phylogenomic databases

eggNOGⁱ	KOG0749. Eukaryota. ENOG410XNW0. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011543.
HOGENOMⁱ	HOG000245391.
KEGG Orthology (KO) More...KOⁱ	K05863.
OMAⁱ	QHASKTI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ULB.

Enzyme and pathway databases

Reactomeⁱ	R-DME-1268020. Mitochondrial protein import. R-DME-422356. Regulation of insulin secretion.

Reactomeⁱ

R-DME-1268020. Mitochondrial protein import.
R-DME-422356. Regulation of insulin secretion.

Miscellaneous databases

ChiTaRSⁱ	Ant2. fly.
GenomeRNAiⁱ	32008.

Gene expression databases

Bgeeⁱ	FBgn0025111.

Bgeeⁱ

FBgn0025111.

Family and domain databases

Gene3Dⁱ	1.50.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR002113. Aden_trnslctor. IPR002067. Mit_carrier. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153. Mito_carr. 3 hits.
PRINTSⁱ	PR00927. ADPTRNSLCASE. PR00926. MITOCARRIER.
SUPFAMⁱ	SSF103506. SSF103506. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50920. SOLCAR. 3 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O62526_DROME
Accessionⁱ	O62526Primary (citable) accession number: O62526
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	August 1, 1998
	Last sequence update:	August 1, 1998
	Last modified:	August 30, 2017
	This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O62526 (O62526_DROME)

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ADP/ATP translocase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ