Spindle assembly abnormal protein 6 - Caenorhabditis elegans

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O62479 (SAS6_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 72. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Spindle assembly abnormal protein 6

Gene names

Name:	sas-6
ORF Names:	Y45F10D.9

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for centrosome duplication. Participates in centriole assembly. Ref.2 Ref.3
Subunit structure	Interacts with sas-5. Ref.3
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton › centrosome › centriole. Note: Localizes to centrioles, zyg-1 and sas-5 are required for centriole localization. Ref.2 Ref.3
Developmental stage	Recruited to centrioles at the onset of the centrosome duplication cycle, then associates with the emerging daughter centriole. Ref.2 Ref.3
Domain	The coiled coil domain is necessary and sufficient for interaction with sas-5. Ref.3
Sequence similarities	Contains 1 PISA domain.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Cytoplasm Cytoskeleton
Domain	Coiled coil
Molecular function	Developmental protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	centriole replication Inferred from mutant phenotype Ref.3. Source: WormBase embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase locomotion Inferred from mutant phenotype. Source: WormBase morphogenesis of an epithelium Inferred from mutant phenotype. Source: WormBase protein localization Inferred from mutant phenotype Ref.3. Source: WormBase
Cellular component	centriole Inferred from direct assay Ref.3. Source: WormBase
Molecular function	identical protein binding Inferred from physical interaction. Source: IntAct protein domain specific binding Inferred from physical interaction Ref.3. Source: WormBase
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		6	EBI-327247,EBI-327247
sas-5	Q20010	5	EBI-327247,EBI-327608

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 492

492

Spindle assembly abnormal protein 6

PRO_0000189978

Regions

Domain

46 – 98

PISA

Coiled coil

192 – 407

216

Potential

Secondary structure

492

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

O62479 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 118ED9B5EF6357A6
Show »

FASTA

492

56,038

        10         20         30         40         50         60 
MTSKIALFDQ TLIASLLQPL SLNQPDFKAY KTKVKLKISE QRNETSGEKE LKFEISRSDD 

        70         80         90        100        110        120 
FEFLFSETLN NEKYQILARD HDLTVDFDAF PKVIIQHLLC KNIVKNLEED GEVDARKKAG 

       130        140        150        160        170        180 
YHSIADPGKP TEINIILDAE KNFCSFELFS KTPISKGKIF SIKLHAVRGD HLISHLLKIC 

       190        200        210        220        230        240 
SSQAVKLSTF YKSADELASL RQKCGDLEKQ VEKLSGVKEE FEEMSEKFKE LEDEVELVKE 

       250        260        270        280        290        300 
ERENIRLLVE DKEDEVADLK QDTESLQKQL EENQEELEIV GNMLREEQGK VDQLQKRNVA 

       310        320        330        340        350        360 
HQKEIGKLRA ELGTAQRNLE KADQLLKRNS QQQNQQSLDM RKLGELEADL KEKDSMVESL 

       370        380        390        400        410        420 
TETIGILRKE LENEKLKAAE NMDSFEKLSM ENENLKEKIA HYRAQRFSPA PSGLPGLQTG 

       430        440        450        460        470        480 
LTNRLTPSFK PVLGPHTPYG ANLNSRTPFR DNTTLNFQNS TIATPHAFRF NSQLIADETT 

       490 
GSSVTNTPPA QR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
[2]	"Centriole assembly requires both centriolar and pericentriolar material proteins." Dammermann A., Mueller-Reichert T., Pelletier L., Habermann B., Desai A., Oegema K. Dev. Cell 7:815-829(2004) [PubMed: 15572125] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[3]	"SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells." Leidel S., Delattre M., Cerutti L., Baumer K., Goenczy P. Nat. Cell Biol. 7:115-125(2005) [PubMed: 15665853] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, DOMAIN, DEVELOPMENTAL STAGE, INTERACTION WITH SAS-5.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AL021492 Genomic DNA. Translation: CAA16384.1.

PIR

T26936.

RefSeq

NP_502660.1. NM_070259.4.

UniGene

Cel.9095.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3PYI	X-ray	2.10	A/B	1-168	[»]

ProteinModelPortal

O62479.

SMR

O62479. Positions 3-167.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-24495N.

IntAct

O62479. 7 interactions.

MINT

MINT-1119015.

STRING

O62479.

Proteomic databases

PRIDE

O62479.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

Y45F10D.9; Y45F10D.9; Y45F10D.9.

GeneID

178345.

KEGG

cel:Y45F10D.9.

NMPDR

fig|6239.3.peg.15827.

UCSC

Y45F10D.9. c. elegans.

Organism-specific databases

CTD

43555.

WormBase

Y45F10D.9; CE16647; WBGene00012888; sas-6.

Phylogenomic databases

eggNOG

meNOG06532.

GeneTree

EMGT00050000011422.

InParanoid

O62479.

OMA

ELKFEIS.

Family and domain databases

ProtoNet

Search...

Other

NextBio

900750.

Entry information

Entry name

SAS6_CAEEL

Accession

Primary (citable) accession number: O62479

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	August 1, 1998
Last modified:	November 16, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents