Reviewed, UniProtKB/Swiss-Prot O62461 (SELD_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable selenide, water dikinase
    EC=2.7.9.3
Alternative name(s):
    Selenophosphate synthetase 1
    Selenium donor protein

Gene names

Name:	seld-1
ORF Names:	Y45F10A.4

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Synthesizes selenophosphate from selenide and ATP Potential.
Catalytic activity	ATP + selenide + H2O = AMP + selenophosphate + phosphate.
Sequence similarities	Belongs to the selenophosphate synthetase 1 family. Class I subfamily.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding Selenium
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW selenide, water dikinase activity Inferred from electronic annotation. Source: EC selenium binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	Probable selenide, water dikinase		PRO_0000127654
Regions
	Nucleotide binding	263 – 269	7	ATP Potential
Sites
	Active site	33	1	Potential
	Site	36	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	O62461-1 [UniParc]. Last modified December 19, 2001. Version 2. Checksum: 66E0A5E10B1653E5	FASTA	378	41,555
	10 20 30 40 50 60 MNRIERILEG FDPVSNGLDE DFVLTKLTGM KGCGCKVPRN VLLQLLQTFK TDLVINNDEV 70 80 90 100 110 120 DIGLDSCVIP LRHPGLRLVQ TTDFFYPLID DPYIMGRVTC ANVLSDLYAM GVSECDNMLM 130 140 150 160 170 180 LLAVAIDLNE KQRDIVVPLF IQGFKDAADE AGTKIRGGQT VRCPWLLLGG VATSVAHESE 190 200 210 220 230 240 IIKVDQAVPG DVLILTKPIG GQVAVNSYEW IKKKNGKIEE LNLEIPKIEK AFKQVCEQMS 250 260 270 280 290 300 RLNRNAAKLL HKYDAHSSTD VTGFGLLGHA ENLARVQKQP MEFIIEKLPI IEYMDEIADK 310 320 330 340 350 360 MIAKGGEGFK LYQGTSAETS GGLLIAMSEE NAKKYIAELS SLDNAPAWII GKVTAKTTDS 370 SIARILPDAV RISVPSHI

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL021488 Genomic DNA. Translation: CAA16367.2.
PIR	T26910.
RefSeq	NP_502604.1.
UniGene	Cel.28182
3D structure databases
SMR	O62461. Positions 22-357.
ModBase	Search...
Protein-protein interaction databases
STRING	O62461.
Genome annotation databases
Ensembl	Y45F10A.4; Y45F10A.4; Y45F10A.4; Caenorhabditis elegans. [Genome view]
GeneID	189912.
KEGG	cel:Y45F10A.4.
NMPDR	fig|6239.3.peg.15762.
Organism-specific databases
CTD	189912.
WormBase	WBGene00012867. seld-1.
WormPep	Y45F10A.4. CE28704. [WorfDB]
Phylogenomic databases
eggNOG	meNOG05530.
HOGENOM	HBG383791.
InParanoid	O62461.
OMA	GMDSCVI.
PhylomeDB	O62461.
Enzyme and pathway databases
BRENDA	2.7.9.3. 672.
Gene expression databases
ArrayExpress	O62461.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR016188. PurM_N-like. IPR004536. SelD. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF036407. Selenphspht_syn. 1 hit.
TIGRFAMs	TIGR00476. selD. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	944024.

Entry information

Entry name

SELD_CAEEL

Accession

Primary (citable) accession number: O62461

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	December 19, 2001
Last modified:	February 9, 2010
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project