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O62431 (SYQ_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glutamine--tRNA ligase

EC=6.1.1.18
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name=GlnRS
Gene names
Name:ers-1
Synonyms:qrs-5
ORF Names:Y41E3.4
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length786 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutaminyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 786786Probable glutamine--tRNA ligase
PRO_0000195861

Regions

Motif276 – 28611"HIGH" region
Motif499 – 5035"KMSKS" region

Sites

Binding site5021ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
O62431 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: D00F343D845F4B47

FASTA78688,262
        10         20         30         40         50         60 
MATKEELLSL GLSDSKVAET LKNVKLTETI GSIVKLASES GEISKQKGTL LYQLATKLKP 

        70         80         90        100        110        120 
QVAAHTPLVV KYIMNDGIKT EPQLSAAIEY LLSHTVKGIQ VPDFEKSCGV GVVVTIDDIE 

       130        140        150        160        170        180 
AAVTKVIGQH REKIVAERYS FPAGKLLGEL RALLPWADGA ITKKEVDLRF LELLGPKTAE 

       190        200        210        220        230        240 
DLAPKKKEKK PEGPKPSKDA AAAATAPGTK NQKEASPEEF ADGAETMDEL LRTRAHFHKV 

       250        260        270        280        290        300 
GENFKQDGYV TTPKTAELLK AHVAAVGGKV VTRFPPEPNG VLHIGHAKAI NINFGYAKAM 

       310        320        330        340        350        360 
GGVCNLRFDD TNPEKEEEKF FSAIEDIVHW LGYDPARVTH SSDNFQQLYL WAVKLIQKGL 

       370        380        390        400        410        420 
AFVCHQKVEE MRGFEVQLSP WRERPIEENI QLFEDMKNGK FDEGEATLRL KLTLEEGKVD 

       430        440        450        460        470        480 
PVAYRIKYVP HHRTGNQWCI YPTYDYTHCL CDSIENITHS LCTKEFQSRR SSYYWLCNAL 

       490        500        510        520        530        540 
DIYCPVQWEY GRLNVNYTVV SKRKILKLIT TKTVNDWDDP RLFTLTALRR RGIPSEAINR 

       550        560        570        580        590        600 
FVAKLGLTMS QMVIDPHVLD ATVRDYLNIH APRTMAVLEG LKLTIENFSE LNLPSSVDVP 

       610        620        630        640        650        660 
DFPSDPTDPR KHSVSVDREI FIEKSDYKPD DSDKSFRRLT PKQAVGLKHI GLVLRFVKEV 

       670        680        690        700        710        720 
KDAEGHVTEV VVKAEKLSEK DKPKAFIHWV AKPVSCEVRL YDRLFKSKNP EDAQLVPGGF 

       730        740        750        760        770        780 
LSDINPDSLT VVYNALIDQS IAKSKVYDRF QFERIGFFCV DRDSTSSTLV FNRTVMLKDG 


GASGKN 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z95559 Genomic DNA. Translation: CAB08998.1.
PIRT26811.
RefSeqNP_001255843.1. NM_001268914.1.
UniGeneCel.7782.

3D structure databases

ProteinModelPortalO62431.
SMRO62431. Positions 2-182, 240-779.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.Y41E3.4.

Proteomic databases

PaxDbO62431.
PRIDEO62431.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaY41E3.4a.1; Y41E3.4a.1; Y41E3.4.
Y41E3.4a.2; Y41E3.4a.2; Y41E3.4.
GeneID178415.
KEGGcel:CELE_Y41E3.4.
UCSCY41E3.4. c. elegans.

Organism-specific databases

CTD178415.
WormBaseY41E3.4a; CE18372; WBGene00001336; qars-1.

Phylogenomic databases

eggNOGCOG0008.
HOGENOMHOG000259233.
InParanoidO62431.
KOK01886.
OMAVTHSICT.
PhylomeDBO62431.

Family and domain databases

Gene3D1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR007638. Gln-tRNA-synth_Ib_RNA-bd_2.
IPR007639. Gln-tRNA-synth_Ib_RNA-bd_N.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR10119. PTHR10119. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PF04558. tRNA_synt_1c_R1. 1 hit.
PF04557. tRNA_synt_1c_R2. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF50715. SSF50715. 1 hit.
TIGRFAMsTIGR00440. glnS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio901048.
PROO62431.

Entry information

Entry nameSYQ_CAEEL
AccessionPrimary (citable) accession number: O62431
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries