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Protein

Probable glutamine--tRNA ligase

Gene

ers-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei309L-glutamineBy similarity1
Binding sitei444L-glutamineBy similarity1
Binding sitei463ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi277 – 279ATPBy similarity3
Nucleotide bindingi283 – 289ATPBy similarity7
Nucleotide bindingi492 – 493ATPBy similarity2
Nucleotide bindingi500 – 502ATPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamine--tRNA ligase (EC:6.1.1.18By similarity)
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name:
GlnRS
Gene namesi
Name:ers-1
Synonyms:qrs-5
ORF Names:Y41E3.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY41E3.4a; CE18372; WBGene00001336; qars-1.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001958611 – 786Probable glutamine--tRNA ligaseAdd BLAST786

Proteomic databases

EPDiO62431.
PaxDbiO62431.
PeptideAtlasiO62431.
PRIDEiO62431.

PTM databases

iPTMnetiO62431.

Expressioni

Gene expression databases

BgeeiWBGene00001336.
ExpressionAtlasiO62431. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y41E3.4a.2.

Structurei

3D structure databases

ProteinModelPortaliO62431.
SMRiO62431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi276 – 286"HIGH" regionAdd BLAST11
Motifi499 – 503"KMSKS" region5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1148. Eukaryota.
COG0008. LUCA.
GeneTreeiENSGT00550000074972.
HOGENOMiHOG000259233.
InParanoidiO62431.
KOiK01886.
OMAiVTHSICT.
OrthoDBiEOG091G026F.
PhylomeDBiO62431.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR007638. Gln-tRNA-synth_Ib_RNA-bd_2.
IPR007639. Gln-tRNA-synth_Ib_RNA-bd_N.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PF04558. tRNA_synt_1c_R1. 1 hit.
PF04557. tRNA_synt_1c_R2. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

O62431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKEELLSL GLSDSKVAET LKNVKLTETI GSIVKLASES GEISKQKGTL
60 70 80 90 100
LYQLATKLKP QVAAHTPLVV KYIMNDGIKT EPQLSAAIEY LLSHTVKGIQ
110 120 130 140 150
VPDFEKSCGV GVVVTIDDIE AAVTKVIGQH REKIVAERYS FPAGKLLGEL
160 170 180 190 200
RALLPWADGA ITKKEVDLRF LELLGPKTAE DLAPKKKEKK PEGPKPSKDA
210 220 230 240 250
AAAATAPGTK NQKEASPEEF ADGAETMDEL LRTRAHFHKV GENFKQDGYV
260 270 280 290 300
TTPKTAELLK AHVAAVGGKV VTRFPPEPNG VLHIGHAKAI NINFGYAKAM
310 320 330 340 350
GGVCNLRFDD TNPEKEEEKF FSAIEDIVHW LGYDPARVTH SSDNFQQLYL
360 370 380 390 400
WAVKLIQKGL AFVCHQKVEE MRGFEVQLSP WRERPIEENI QLFEDMKNGK
410 420 430 440 450
FDEGEATLRL KLTLEEGKVD PVAYRIKYVP HHRTGNQWCI YPTYDYTHCL
460 470 480 490 500
CDSIENITHS LCTKEFQSRR SSYYWLCNAL DIYCPVQWEY GRLNVNYTVV
510 520 530 540 550
SKRKILKLIT TKTVNDWDDP RLFTLTALRR RGIPSEAINR FVAKLGLTMS
560 570 580 590 600
QMVIDPHVLD ATVRDYLNIH APRTMAVLEG LKLTIENFSE LNLPSSVDVP
610 620 630 640 650
DFPSDPTDPR KHSVSVDREI FIEKSDYKPD DSDKSFRRLT PKQAVGLKHI
660 670 680 690 700
GLVLRFVKEV KDAEGHVTEV VVKAEKLSEK DKPKAFIHWV AKPVSCEVRL
710 720 730 740 750
YDRLFKSKNP EDAQLVPGGF LSDINPDSLT VVYNALIDQS IAKSKVYDRF
760 770 780
QFERIGFFCV DRDSTSSTLV FNRTVMLKDG GASGKN
Length:786
Mass (Da):88,262
Last modified:August 1, 1998 - v1
Checksum:iD00F343D845F4B47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z95559 Genomic DNA. Translation: CAB08998.1.
PIRiT26811.
RefSeqiNP_001255843.1. NM_001268914.1.
UniGeneiCel.7782.

Genome annotation databases

EnsemblMetazoaiY41E3.4a; Y41E3.4a; WBGene00001336.
GeneIDi178415.
KEGGicel:CELE_Y41E3.4.
UCSCiY41E3.4. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiSYQ_CAEEL
AccessioniPrimary (citable) accession number: O62431
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: August 30, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. SIMILARITY comments
    Index of protein domains and families