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Protein

Probable glutamine--tRNA ligase

Gene

ers-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei502 – 5021ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamine--tRNA ligase (EC:6.1.1.18)
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name:
GlnRS
Gene namesi
Name:ers-1
Synonyms:qrs-5
ORF Names:Y41E3.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY41E3.4a; CE18372; WBGene00001336; qars-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 786786Probable glutamine--tRNA ligasePRO_0000195861Add
BLAST

Proteomic databases

PaxDbiO62431.
PRIDEiO62431.

Expressioni

Gene expression databases

ExpressionAtlasiO62431. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y41E3.4a.2.

Structurei

3D structure databases

ProteinModelPortaliO62431.
SMRiO62431. Positions 2-182, 227-779.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi276 – 28611"HIGH" regionAdd
BLAST
Motifi499 – 5035"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
GeneTreeiENSGT00550000074972.
HOGENOMiHOG000259233.
InParanoidiO62431.
OMAiIFYSDGN.
PhylomeDBiO62431.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR007638. Gln-tRNA-synth_Ib_RNA-bd_2.
IPR007639. Gln-tRNA-synth_Ib_RNA-bd_N.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PF04558. tRNA_synt_1c_R1. 1 hit.
PF04557. tRNA_synt_1c_R2. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKEELLSL GLSDSKVAET LKNVKLTETI GSIVKLASES GEISKQKGTL
60 70 80 90 100
LYQLATKLKP QVAAHTPLVV KYIMNDGIKT EPQLSAAIEY LLSHTVKGIQ
110 120 130 140 150
VPDFEKSCGV GVVVTIDDIE AAVTKVIGQH REKIVAERYS FPAGKLLGEL
160 170 180 190 200
RALLPWADGA ITKKEVDLRF LELLGPKTAE DLAPKKKEKK PEGPKPSKDA
210 220 230 240 250
AAAATAPGTK NQKEASPEEF ADGAETMDEL LRTRAHFHKV GENFKQDGYV
260 270 280 290 300
TTPKTAELLK AHVAAVGGKV VTRFPPEPNG VLHIGHAKAI NINFGYAKAM
310 320 330 340 350
GGVCNLRFDD TNPEKEEEKF FSAIEDIVHW LGYDPARVTH SSDNFQQLYL
360 370 380 390 400
WAVKLIQKGL AFVCHQKVEE MRGFEVQLSP WRERPIEENI QLFEDMKNGK
410 420 430 440 450
FDEGEATLRL KLTLEEGKVD PVAYRIKYVP HHRTGNQWCI YPTYDYTHCL
460 470 480 490 500
CDSIENITHS LCTKEFQSRR SSYYWLCNAL DIYCPVQWEY GRLNVNYTVV
510 520 530 540 550
SKRKILKLIT TKTVNDWDDP RLFTLTALRR RGIPSEAINR FVAKLGLTMS
560 570 580 590 600
QMVIDPHVLD ATVRDYLNIH APRTMAVLEG LKLTIENFSE LNLPSSVDVP
610 620 630 640 650
DFPSDPTDPR KHSVSVDREI FIEKSDYKPD DSDKSFRRLT PKQAVGLKHI
660 670 680 690 700
GLVLRFVKEV KDAEGHVTEV VVKAEKLSEK DKPKAFIHWV AKPVSCEVRL
710 720 730 740 750
YDRLFKSKNP EDAQLVPGGF LSDINPDSLT VVYNALIDQS IAKSKVYDRF
760 770 780
QFERIGFFCV DRDSTSSTLV FNRTVMLKDG GASGKN
Length:786
Mass (Da):88,262
Last modified:August 1, 1998 - v1
Checksum:iD00F343D845F4B47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z95559 Genomic DNA. Translation: CAB08998.1.
PIRiT26811.
RefSeqiNP_001255843.1. NM_001268914.1.
UniGeneiCel.7782.

Genome annotation databases

EnsemblMetazoaiY41E3.4a; Y41E3.4a; WBGene00001336.
GeneIDi178415.
UCSCiY41E3.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z95559 Genomic DNA. Translation: CAB08998.1.
PIRiT26811.
RefSeqiNP_001255843.1. NM_001268914.1.
UniGeneiCel.7782.

3D structure databases

ProteinModelPortaliO62431.
SMRiO62431. Positions 2-182, 227-779.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y41E3.4a.2.

Proteomic databases

PaxDbiO62431.
PRIDEiO62431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY41E3.4a; Y41E3.4a; WBGene00001336.
GeneIDi178415.
UCSCiY41E3.4. c. elegans.

Organism-specific databases

CTDi178415.
WormBaseiY41E3.4a; CE18372; WBGene00001336; qars-1.

Phylogenomic databases

eggNOGiCOG0008.
GeneTreeiENSGT00550000074972.
HOGENOMiHOG000259233.
InParanoidiO62431.
OMAiIFYSDGN.
PhylomeDBiO62431.

Miscellaneous databases

NextBioi901048.
PROiO62431.

Gene expression databases

ExpressionAtlasiO62431. baseline and differential.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR007638. Gln-tRNA-synth_Ib_RNA-bd_2.
IPR007639. Gln-tRNA-synth_Ib_RNA-bd_N.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PF04558. tRNA_synt_1c_R1. 1 hit.
PF04557. tRNA_synt_1c_R2. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiSYQ_CAEEL
AccessioniPrimary (citable) accession number: O62431
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: July 22, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.