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Protein

Lysozyme-like protein 1

Gene

lys-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in resistance to Gram-negative bacterium S.marcescens and to bacterium Gram-positive S.aureus infection.2 Publications

GO - Biological processi

  • defense response to Gram-negative bacterium Source: WormBase
  • defense response to Gram-positive bacterium Source: WormBase
  • innate immune response Source: WormBase

Keywordsi

Molecular functionAntimicrobial
Biological processImmunity, Innate immunity

Protein family/group databases

CAZyiGH25. Glycoside Hydrolase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme-like protein 1Curated
Gene namesi
Name:lys-1Imported
ORF Names:Y22F5A.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiY22F5A.4; CE16605; WBGene00003090; lys-1.

Subcellular locationi

GO - Cellular componenti

  • apical part of cell Source: WormBase
  • cytoplasmic vesicle Source: WormBase
  • cytoplasmic vesicle lumen Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown causes a reduction in survival in response to bacterium S.aureus infection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_500415923717 – 298Lysozyme-like protein 1Sequence analysisAdd BLAST282

Proteomic databases

EPDiO62415.
PaxDbiO62415.
PeptideAtlasiO62415.

Expressioni

Tissue specificityi

Expressed in intestine, IL2 and IL6 neurons and some neurons in the head ganglia.1 Publication

Inductioni

Induced by Gram-negative bacteria S.marcescens and B.thuringiensis infection.2 Publications

Gene expression databases

BgeeiWBGene00003090.

Interactioni

Protein-protein interaction databases

DIPiDIP-26293N.
IntActiO62415. 4 interactors.
MINTiMINT-1097462.
STRINGi6239.Y22F5A.4.2.

Structurei

3D structure databases

ProteinModelPortaliO62415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 25 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KAMN. Eukaryota.
ENOG4110I4K. LUCA.
GeneTreeiENSGT00530000064778.
HOGENOMiHOG000018889.
InParanoidiO62415.
OMAiITGNWAT.
OrthoDBiEOG091G0GXF.
PhylomeDBiO62415.

Family and domain databases

InterProiView protein in InterPro
IPR017853. Glycoside_hydrolase_SF.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O62415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLAFVTFL FALASARPQD VDSNRVVALP QDNFEVTDIG FEKIKAEPAP
60 70 80 90 100
EVVNNDASYA YAVDISVPTT VSQMNCLKTS RYAAVFIRGF TPFGSGAFDT
110 120 130 140 150
TSVTSIRNAY SAGLGIEVYM TPQPLSSLQG YQQLDALYNG LNGNGITIRS
160 170 180 190 200
VWIQVTSPAN WQKSATTNVN FLNSIISRAK QYGLTVGIYT NQYDWSQITG
210 220 230 240 250
NWATLSSDVL LWYWHVLGGG VTGETPATFD DFRAFGSFKK ASVKQFAQVE
260 270 280 290
SVCSLTVNRD VYVVGIPAAA SSKNTDFFTQ EDISSNNKKI VVGGVIGV
Length:298
Mass (Da):32,379
Last modified:August 1, 1998 - v1
Checksum:i2AB1984E5BD234BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAA16323.1.
PIRiT26554.
RefSeqiNP_505642.1. NM_073241.3.
UniGeneiCel.1917.

Genome annotation databases

EnsemblMetazoaiY22F5A.4.1; Y22F5A.4.1; WBGene00003090.
Y22F5A.4.2; Y22F5A.4.2; WBGene00003090.
GeneIDi179428.
KEGGicel:CELE_Y22F5A.4.
UCSCiY22F5A.4.1. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLYS1_CAEEL
AccessioniPrimary (citable) accession number: O62415
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: August 1, 1998
Last modified: June 7, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Caution

Lacks conserved active site residues, suggesting it has no catalytic activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families