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Protein

Nuclear hormone receptor family member nhr-61

Gene

nhr-61

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi27 – 10276Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri30 – 5021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri66 – 9025NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-61
Gene namesi
Name:nhr-61
ORF Names:W01D2.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiW01D2.2a; CE20124; WBGene00003651; nhr-61.
W01D2.2b; CE20125; WBGene00003651; nhr-61.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Nuclear hormone receptor family member nhr-61PRO_0000053791Add
BLAST

Proteomic databases

PaxDbiO62389.

Expressioni

Gene expression databases

ExpressionAtlasiO62389. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi40423. 1 interaction.
DIPiDIP-24810N.
IntActiO62389. 2 interactions.
MINTiMINT-1120796.
STRINGi6239.W01D2.2b.1.

Structurei

3D structure databases

ProteinModelPortaliO62389.
SMRiO62389. Positions 30-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated
Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri30 – 5021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri66 – 9025NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00840000130053.
InParanoidiO62389.
OMAiGCNGVCY.
PhylomeDBiO62389.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR002999. Tudor.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: O62389-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIVDSISSST ASTSSSSPTR GTPIRKSLQC AVCGDVALGK HYGVNACNGC
60 70 80 90 100
KGFFRRSIWK NRTYACRHGG KCLVAKEQRN ACRSCRLTRC LDVGMNPRAV
110 120 130 140 150
QGDTVEDPEW DEEAMPETLS ISTQTDALKV KKKSHTSLFT LDIKKEQIID
160 170 180 190 200
NLRAIYARTD PEEFWKLTYP GTYDFRYAFH NTKVVSPRTP LTPTAERIAT
210 220 230 240 250
LNDVVADFRR AFVLFVDILK SIDQLRDVQE DDKMKIAKSR FAAFYWWLCS
260 270 280 290 300
TWSAKAGCNG VCYSNGSYHP ASISDMPKSE GKHGVRIDYS GVSQKSLENL
310 320 330 340 350
VEPLRRMELS DEERIVGAVM VILADPVPNV STKTEKILAE ARDFYLELLG
360 370 380 390 400
YCIKLPEEQQ GIRVSTMVLL LASIMELVHL TTDNIQLSDV LHVIDLGDWS
410
QELRDHRYRR QF
Length:412
Mass (Da):46,541
Last modified:November 1, 1998 - v2
Checksum:iB884385113521255
GO
Isoform b (identifier: O62389-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-287: I → IEYV

Show »
Length:415
Mass (Da):46,933
Checksum:i063FF4DAFE4A5EC8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei287 – 2871I → IEYV in isoform b. CuratedVSP_007123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83128 Genomic DNA. Translation: CAB05636.1.
Z83128 Genomic DNA. Translation: CAB05637.1.
PIRiT26056.
T26057.
RefSeqiNP_001022381.1. NM_001027210.4. [O62389-1]
NP_001022382.1. NM_001027211.4. [O62389-2]
UniGeneiCel.18250.

Genome annotation databases

EnsemblMetazoaiW01D2.2a.1; W01D2.2a.1; WBGene00003651. [O62389-1]
W01D2.2a.2; W01D2.2a.2; WBGene00003651. [O62389-1]
W01D2.2a.3; W01D2.2a.3; WBGene00003651. [O62389-1]
GeneIDi175142.
KEGGicel:CELE_W01D2.2.
UCSCiW01D2.2a. c. elegans. [O62389-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83128 Genomic DNA. Translation: CAB05636.1.
Z83128 Genomic DNA. Translation: CAB05637.1.
PIRiT26056.
T26057.
RefSeqiNP_001022381.1. NM_001027210.4. [O62389-1]
NP_001022382.1. NM_001027211.4. [O62389-2]
UniGeneiCel.18250.

3D structure databases

ProteinModelPortaliO62389.
SMRiO62389. Positions 30-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40423. 1 interaction.
DIPiDIP-24810N.
IntActiO62389. 2 interactions.
MINTiMINT-1120796.
STRINGi6239.W01D2.2b.1.

Proteomic databases

PaxDbiO62389.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW01D2.2a.1; W01D2.2a.1; WBGene00003651. [O62389-1]
W01D2.2a.2; W01D2.2a.2; WBGene00003651. [O62389-1]
W01D2.2a.3; W01D2.2a.3; WBGene00003651. [O62389-1]
GeneIDi175142.
KEGGicel:CELE_W01D2.2.
UCSCiW01D2.2a. c. elegans. [O62389-1]

Organism-specific databases

CTDi175142.
WormBaseiW01D2.2a; CE20124; WBGene00003651; nhr-61.
W01D2.2b; CE20125; WBGene00003651; nhr-61.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00840000130053.
InParanoidiO62389.
OMAiGCNGVCY.
PhylomeDBiO62389.

Miscellaneous databases

NextBioi886944.
PROiO62389.

Gene expression databases

ExpressionAtlasiO62389. baseline and differential.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR002999. Tudor.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiNHR61_CAEEL
AccessioniPrimary (citable) accession number: O62389
Secondary accession number(s): Q9U355
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.