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Protein
Submitted name:

CYtochrome P450 family

Gene

cyp-34a2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Submitted name:
CYtochrome P450 familyImported
Gene namesi
Name:cyp-34a2Imported
Synonyms:cyp-34A2Imported
ORF Names:CELE_T10H4.11Imported, T10H4.11Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT10H4.11; CE16396; WBGene00011699; cyp-34A2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 502481Sequence analysisPRO_5004160005Add
BLAST

Proteomic databases

EPDiO62377.
PaxDbiO62377.
PRIDEiO62377.

Interactioni

Protein-protein interaction databases

STRINGi6239.T10H4.11.

Structurei

3D structure databases

ProteinModelPortaliO62377.
SMRiO62377. Positions 24-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000129897.
HOGENOMiHOG000036993.
InParanoidiO62377.
KOiK17956.
OMAiMLLDYNL.
OrthoDBiEOG7RBZ85.
PhylomeDBiO62377.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLILLFSTI LAIALVHQWR ARKQLPRGPY PLPLIGNLHQ LFYYCWKNGG
60 70 80 90 100
LVEGYAEIEK SFGKVYTVWI GPMPTVFISD YDVAQETHVK RANVFGTRYA
110 120 130 140 150
PGIMNYVRFD KGVVASNGEF WQEHRRFALT TLRNFGFGRN IMEERIMDEY
160 170 180 190 200
RYRFKDFATT GNNNMAKSFE TCARSFFDLL TGSVINKVLI NERFEQDDAD
210 220 230 240 250
FEKLKTNLSR GLENTGFLDI FCPVNILQSR FLKWRQDSIF QPLDWILELT
260 270 280 290 300
KRNIAKRVAQ LKSGEHVLHD EPDDFLDAYL MKMYKDEKEG LDSTFTLDNL
310 320 330 340 350
AIDMYDLWIA GQETTSTTLA WACACLLNKP EVVLKAREEL VHVTGGHRSL
360 370 380 390 400
SLTDKKVTPY LSAVISEVQR VASILNVNLF RILEEDTYVG GQPIRAGTAV
410 420 430 440 450
TAHISMIHVD ETLFKNHTEF NPERFLEVEG LDKKMIPFGI GKRACLGESL
460 470 480 490 500
AKAELYLVLG NMLLDYNLEP VGDVPKIQTI TPFGLLKRPP PFKVRFVEVE

KS
Length:502
Mass (Da):57,544
Last modified:August 1, 1998 - v1
Checksum:iA036E2577B1FCB19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB03339.1.
PIRiT24817.
RefSeqiNP_506788.1. NM_074387.1.
UniGeneiCel.35607.

Genome annotation databases

EnsemblMetazoaiT10H4.11; T10H4.11; WBGene00011699.
GeneIDi188400.
KEGGicel:CELE_T10H4.11.
UCSCiT10H4.11. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB03339.1.
PIRiT24817.
RefSeqiNP_506788.1. NM_074387.1.
UniGeneiCel.35607.

3D structure databases

ProteinModelPortaliO62377.
SMRiO62377. Positions 24-499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T10H4.11.

Proteomic databases

EPDiO62377.
PaxDbiO62377.
PRIDEiO62377.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT10H4.11; T10H4.11; WBGene00011699.
GeneIDi188400.
KEGGicel:CELE_T10H4.11.
UCSCiT10H4.11. c. elegans.

Organism-specific databases

CTDi188400.
WormBaseiT10H4.11; CE16396; WBGene00011699; cyp-34A2.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00840000129897.
HOGENOMiHOG000036993.
InParanoidiO62377.
KOiK17956.
OMAiMLLDYNL.
OrthoDBiEOG7RBZ85.
PhylomeDBiO62377.

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-193048. Androgen biosynthesis.
R-CEL-193993. Mineralocorticoid biosynthesis.
R-CEL-194002. Glucocorticoid biosynthesis.
R-CEL-211957. Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.
R-CEL-211976. Endogenous sterols.
R-CEL-211981. Xenobiotics.
R-CEL-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-CEL-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
R-CEL-5423646. Aflatoxin activation and detoxification.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO62377_CAEEL
AccessioniPrimary (citable) accession number: O62377
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.