O62327 (GPX2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glutathione peroxidase R05H10.5
EC=1.11.1.9

Gene names

ORF Names:

R05H10.5

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May constitute a glutathione peroxidase-like protective system against oxidative stresses By similarity.
Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 163	163	Probable glutathione peroxidase R05H10.5		PRO_0000066647
Sites
	Active site	36	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O62327 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 8D5FE6DF96D212CA	FASTA	163	18,152
	10 20 30 40 50 60 MASVHGITVK NAQGEDTPLS NYQGKVLIIV NVASQCGLTN SNYNQFKELL DVYKKDGLEV 70 80 90 100 110 120 LAFPCNQFGG QEPSCEIDIA AFVADKFKFE PTLFQKIDVN GDNTAPLYKF LKQEKGGFLV 130 140 150 160 DAIKWNFTKF LVGRDGHVIK RFSPTTEPKD MKKDIEAALQ AKL

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z83119 Genomic DNA. Translation: CAB05581.1.
PIR	T23936.
RefSeq	NP_497078.1. NM_064677.3.
UniGene	Cel.14641.
3D structure databases
ProteinModelPortal	O62327.
SMR	O62327. Positions 2-160.
ModBase	Search...
Protein-protein interaction databases
STRING	O62327.
Protein family/group databases
PeroxiBase	3747. CelGPx02.
Proteomic databases
PRIDE	O62327.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	R05H10.5; R05H10.5; R05H10.5.
GeneID	187630.
KEGG	cel:R05H10.5.
NMPDR	fig|6239.3.peg.8304.
UCSC	R05H10.5. c. elegans.
Organism-specific databases
CTD	187630.
WormBase	R05H10.5; CE18107; WBGene00011045.
Phylogenomic databases
eggNOG	meNOG14651.
GeneTree	EMGT00050000001082.
HOGENOM	HBG648990.
InParanoid	O62327.
OMA	GIPINRY.
PhylomeDB	O62327.
Gene expression databases
ArrayExpress	O62327.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K00432.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	935924.

Entry information

Entry name

GPX2_CAEEL

Accession

Primary (citable) accession number: O62327

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	November 16, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project