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Protein

Glutathione peroxidase 2

Gene

gpx-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May constitute a glutathione peroxidase-like protective system against oxidative stresses.By similarity

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei36By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Protein family/group databases

PeroxiBasei3747. CelGPx02.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 2 (EC:1.11.1.9)
Gene namesi
Name:gpx-2
ORF Names:R05H10.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiR05H10.5a; CE18107; WBGene00011045; gpx-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000666471 – 163Glutathione peroxidase 2Add BLAST163

Proteomic databases

EPDiO62327.
PaxDbiO62327.
PeptideAtlasiO62327.
PRIDEiO62327.

Expressioni

Gene expression databases

BgeeiWBGene00011045.
ExpressionAtlasiO62327. differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.R05H10.5.

Structurei

3D structure databases

ProteinModelPortaliO62327.
SMRiO62327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00840000130500.
HOGENOMiHOG000277054.
InParanoidiO62327.
OMAiANTHPLY.
PhylomeDBiO62327.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62327-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVHGITVK NAQGEDTPLS NYQGKVLIIV NVASQCGLTN SNYNQFKELL
60 70 80 90 100
DVYKKDGLEV LAFPCNQFGG QEPSCEIDIA AFVADKFKFE PTLFQKIDVN
110 120 130 140 150
GDNTAPLYKF LKQEKGGFLV DAIKWNFTKF LVGRDGHVIK RFSPTTEPKD
160
MKKDIEAALQ AKL
Length:163
Mass (Da):18,152
Last modified:August 1, 1998 - v1
Checksum:i8D5FE6DF96D212CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83119 Genomic DNA. Translation: CAB05581.1.
PIRiT23936.
RefSeqiNP_497078.1. NM_064677.4.
UniGeneiCel.14641.

Genome annotation databases

EnsemblMetazoaiR05H10.5a.1; R05H10.5a.1; WBGene00011045.
R05H10.5a.2; R05H10.5a.2; WBGene00011045.
GeneIDi187630.
UCSCiR05H10.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83119 Genomic DNA. Translation: CAB05581.1.
PIRiT23936.
RefSeqiNP_497078.1. NM_064677.4.
UniGeneiCel.14641.

3D structure databases

ProteinModelPortaliO62327.
SMRiO62327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.R05H10.5.

Protein family/group databases

PeroxiBasei3747. CelGPx02.

Proteomic databases

EPDiO62327.
PaxDbiO62327.
PeptideAtlasiO62327.
PRIDEiO62327.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR05H10.5a.1; R05H10.5a.1; WBGene00011045.
R05H10.5a.2; R05H10.5a.2; WBGene00011045.
GeneIDi187630.
UCSCiR05H10.5. c. elegans.

Organism-specific databases

CTDi187630.
WormBaseiR05H10.5a; CE18107; WBGene00011045; gpx-2.

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00840000130500.
HOGENOMiHOG000277054.
InParanoidiO62327.
OMAiANTHPLY.
PhylomeDBiO62327.

Miscellaneous databases

PROiO62327.

Gene expression databases

BgeeiWBGene00011045.
ExpressionAtlasiO62327. differential.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPX2_CAEEL
AccessioniPrimary (citable) accession number: O62327
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.