Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcium/calmodulin-dependent protein kinase type II

Gene

unc-43

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. Involved in activation of ADF neurons and increased tph-1 transcription following exposure to pathogenic bacteria which leads to learned olfactory aversion to the bacteria. Implicated in the muscle regulation of spicule protraction. In conjunction with egl-2 has a role in the suppression of mating behavior under food deprivation to encourage foraging. Involved in restricting str-2 expression to only one of the two AWC neurons. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.14 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Enzyme regulationi

Ca2+/calmodulin binding removes an autoinhibitory regulatory segment located C-terminal to the kinase domain. This releases the catalytic activity of the enzyme and makes accessible a regulatory residue Thr-284. Phosphorylation of Thr-284 by another kinase domain within the oligomeric holoenzyme keeps CaMKII active in the absence of Ca2+/calmodulin by preventing the rebinding of the regulatory segment to the kinase domain and by increasing the affinity of calmodulin for the enzyme. Can respond to high-frequency Ca2+ pulses to become Ca2+ independent.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41ATPPROSITE-ProRule annotation1 Publication1
Active sitei134Proton acceptorCurated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calmodulin-dependent protein kinase activity Source: WormBase
  • ion channel binding Source: WormBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • MAPK cascade Source: WormBase
  • medium-term memory Source: WormBase
  • peptidyl-serine phosphorylation Source: WormBase
  • peptidyl-threonine phosphorylation Source: WormBase
  • positive regulation of gene expression Source: UniProtKB
  • protein phosphorylation Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.17. 1045.
SignaLinkiO62305.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type II1 Publication (EC:2.7.11.17)
Short name:
CaM kinase II1 Publication
Alternative name(s):
Uncoordinated protein 43
Gene namesi
Name:unc-43
ORF Names:K11E8.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK11E8.1a; CE42693; WBGene00006779; unc-43.
K11E8.1b; CE28052; WBGene00006779; unc-43.
K11E8.1d; CE28054; WBGene00006779; unc-43.
K11E8.1e; CE28055; WBGene00006779; unc-43.
K11E8.1f; CE28056; WBGene00006779; unc-43.
K11E8.1g; CE28057; WBGene00006779; unc-43.
K11E8.1h; CE28058; WBGene00006779; unc-43.
K11E8.1i; CE28059; WBGene00006779; unc-43.
K11E8.1k; CE28060; WBGene00006779; unc-43.
K11E8.1l; CE28061; WBGene00006779; unc-43.
K11E8.1m; CE35590; WBGene00006779; unc-43.
K11E8.1n; CE40979; WBGene00006779; unc-43.
K11E8.1o; CE41430; WBGene00006779; unc-43.
K11E8.1p; CE42670; WBGene00006779; unc-43.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cell projectionaxon 1 Publication
  • Perikaryon 2 Publications

  • Note: Localizes at or near the Golgi apparatus (PubMed:16079277). Localizes to post-synaptic regions and is enriched in punctate structures in axons of AWC neurons where it co-localizes with tir-1. Localization is regulated by tir-1 (PubMed:15625192).2 Publications

GO - Cellular componenti

  • axon cytoplasm Source: WormBase
  • neuron projection Source: WormBase
  • perikaryon Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Increased frequency of defecation, typified by a weaker repetition of the defecation motor program, an echo, 10 s after the primary motor program. Abnormal spicule protraction. Lack of tph-1 transcriptional up-regulation during learned olfactory aversion to bacteria. Reduced brood size, body length and width. Lethargic movement. A gain-of function mutation reduces locomotory activity, alters excitation of three muscle types and lengthens the period of the motor output of a behavioral clock. Both classes of mutation inhibit neurotransmitter release.6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi41K → M: Loss of kinase activity. 1 Publication1
Mutagenesisi97F → E: Loss of cooperative activation of adjacent holoenzyme subunits. 2 Publications1
Mutagenesisi97F → K: Increase in calcium independent kinase activity, no effect on translocation to the neurite. 2 Publications1
Mutagenesisi100I → K: Loss of cooperative activation of adjacent holoenzyme subunits. 1 Publication1
Mutagenesisi108E → K in n498gf; slight increase in calcium independent kinase activity, no effect on translocation to the neurite. Nuclear translocation of daf-16 resulting in lifespan extension. 3 Publications1
Mutagenesisi134D → N: Loss of autoinhibition and increase in binding of Ca2+/calmodulin. 2 Publications1
Mutagenesisi147K → E: Slight increase in calcium independent kinase activity, no effect on translocation to the neurite. 1 Publication1
Mutagenesisi170G → E in sy574; abnormal spicule protraction; when associated with V-665. 1 Publication1
Mutagenesisi179S → L in e408; males display locomotor and muscle seizure defects and egg laying defects. 1 Publication1
Mutagenesisi200I → K: Loss of cooperative activation of adjacent holoenzyme subunits. 1 Publication1
Mutagenesisi236D → R: Increase in calcium independent kinase activity, loss of translocation to neurites and glr-1 trafficking. 1 Publication1
Mutagenesisi278 – 279AI → DD: Decrease in binding of Ca2+/calmodulin. 1 Publication2
Mutagenesisi280H → K: Increase in calcium independent kinase activity, no effect on translocation to the neurite. 1 Publication1
Mutagenesisi281R → E: Increase in calcium independent kinase activity and translocation to an unlocalized pool in the neurite. Small decrease in glr-1 trafficking. 1 Publication1
Mutagenesisi284T → D: Constitutively activate kinase activity, increase in translocation to the neurites. 1 Publication1
Mutagenesisi665A → V in sy574; abnormal spicule protraction; when associated with E-170. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003966451 – 720Calcium/calmodulin-dependent protein kinase type IIAdd BLAST720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284Phosphothreonine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO62305.
PeptideAtlasiO62305.
PRIDEiO62305.

PTM databases

iPTMnetiO62305.

Expressioni

Tissue specificityi

Expressed in the nervous system. Observed in the ADF and AWC neurons. Position in AWC neurons is regulated by microtubules. Localized to clusters in ventral cord neurites which appear to be required for glr-1 trafficking. Also present in oocytes.4 Publications

Interactioni

Subunit structurei

Dodecamer. Subunits are tightly packed around a central ring-shaped scaffold with extensive contacts between the regulatory segment of one kinase and the catalytic domain of another enabling cooperative activation of a subunit by the adjacent molecule (PubMed:16441656, PubMed:20139983). Interacts with and phosphorylates daf-16; the interaction promotes daf-16 nuclear localization. Interacts with egl-2 and tir-1 (PubMed:15625192, PubMed:21145946). Interacts with nsy-1 (PubMed:11336672).5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
syx-4P914093EBI-313095,EBI-326499

GO - Molecular functioni

  • ion channel binding Source: WormBase

Protein-protein interaction databases

BioGridi43023. 8 interactors.
DIPiDIP-25971N.
DIP-58986N.
IntActiO62305. 8 interactors.
MINTiMINT-115321.

Structurei

Secondary structure

1720
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni7 – 11Combined sources5
Beta strandi12 – 21Combined sources10
Beta strandi24 – 31Combined sources8
Turni32 – 34Combined sources3
Beta strandi37 – 44Combined sources8
Helixi45 – 47Combined sources3
Helixi50 – 65Combined sources16
Beta strandi74 – 79Combined sources6
Beta strandi81 – 88Combined sources8
Helixi96 – 103Combined sources8
Helixi108 – 127Combined sources20
Helixi137 – 139Combined sources3
Beta strandi140 – 146Combined sources7
Beta strandi151 – 153Combined sources3
Helixi175 – 177Combined sources3
Helixi180 – 183Combined sources4
Helixi191 – 206Combined sources16
Helixi216 – 225Combined sources10
Turni232 – 237Combined sources6
Helixi240 – 249Combined sources10
Turni254 – 256Combined sources3
Helixi260 – 263Combined sources4
Helixi267 – 270Combined sources4
Helixi275 – 277Combined sources3
Helixi282 – 310Combined sources29
Helixi544 – 547Combined sources4
Helixi586 – 604Combined sources19
Helixi607 – 613Combined sources7
Beta strandi614 – 621Combined sources8
Helixi623 – 625Combined sources3
Helixi634 – 637Combined sources4
Beta strandi640 – 642Combined sources3
Beta strandi649 – 660Combined sources12
Turni661 – 663Combined sources3
Beta strandi664 – 676Combined sources13
Beta strandi682 – 696Combined sources15
Beta strandi699 – 708Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BDWX-ray1.80A/B1-543[»]
2F86X-ray2.64B/D/F/H/J/L/N540-720[»]
3KK8X-ray1.72A5-288[»]
3KK9X-ray3.21A6-287[»]
3KL8X-ray3.37A/C/E/G/I5-273[»]
ProteinModelPortaliO62305.
SMRiO62305.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO62305.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 269Protein kinasePROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO62305.
PhylomeDBiO62305.

Family and domain databases

Gene3Di3.10.450.50. 1 hit.
InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543. Ca/CaM-dep_prot_kinase-assoc.
IPR011009. Kinase-like_dom.
IPR032710. NTF2-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 2 hits.
PfamiPF08332. CaMKII_AD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (15)i

Sequence statusi: Complete.

This entry describes 15 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform c1 Publication (identifier: O62305-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMNASTKFSD NYDVKEELGK GAFSVVRRCV HKTTGLEFAA KIINTKKLSA
60 70 80 90 100
RDFQKLEREA RICRKLQHPN IVRLHDSIQE ESFHYLVFDL VTGGELFEDI
110 120 130 140 150
VAREFYSEAD ASHCIQQILE SIAYCHSNGI VHRDLKPENL LLASKAKGAA
160 170 180 190 200
VKLADFGLAI EVNDSEAWHG FAGTPGYLSP EVLKKDPYSK PVDIWACGVI
210 220 230 240 250
LYILLVGYPP FWDEDQHRLY AQIKAGAYDY PSPEWDTVTP EAKSLIDSML
260 270 280 290 300
TVNPKKRITA DQALKVPWIC NRERVASAIH RQDTVDCLKK FNARRKLKAA
310 320 330 340 350
ISAVKMVTRM SGVLRTSDST GSVASNGSTT HDASQVAGTS SQPTSPAAEV
360 370 380 390 400
YPNVLLFNPQ KFPRNCVHPF TTHPYYSPKE SSKKKLFFTL LFEVCPHTSR
410 420 430 440 450
SHILLRDNTK NIYHPYHCFT NKMSNYERAA PSSHGSSTTK KIANAIADLV
460 470 480 490 500
IRRSSPSIRR KTEADVHNSN RNRKVSAPAN LQHALVPVID VVVATGALAS
510 520 530 540 550
SSVDNLSAST SSDLGRNLLN KKEQGPPSTI KESSESSQTI DDNDSEKGGG
560 570 580 590 600
QLKHENTVVR ADGATGIVSS SNSSTASKSS STNLSAQKQD IVRVTQTLLD
610 620 630 640 650
AISCKDFETY TRLCDTSMTC FEPEALGNLI EGIEFHRFYF DGNRKNQVHT
660 670 680 690 700
TMLNPNVHII GEDAACVAYV KLTQFLDRNG EAHTRQSQES RVWSKKQGRW
710 720
VCVHVHRSTQ PSTNTTVSEF
Note: No experimental confirmation available.Curated
Length:720
Mass (Da):79,927
Last modified:October 1, 2001 - v2
Checksum:i3231366FFF81A695
GO
Isoform a1 Publication (identifier: O62305-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-490: Missing.
     491-515: VVVATGALASSSVDNLSASTSSDLG → MKNIEYWQVLLNKIFATYKIKMKQC

Note: No experimental confirmation available.Curated
Show »
Length:230
Mass (Da):25,873
Checksum:i2EAD0E576BA0619A
GO
Isoform b1 Publication (identifier: O62305-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-138: HCIQQILESIAYCHSNGIVHRDLKPE → CCIMQILDGVNYCHQRGIVHRDMKV
     139-720: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:137
Mass (Da):15,801
Checksum:iDDF4E2AD6FC2A6F4
GO
Isoform d2 Publications (identifier: O62305-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-314: AAISAVKMVTRMSGVL → GAILTTMIATRNLSNL
     315-514: Missing.
     548-585: Missing.

Show »
Length:482
Mass (Da):54,589
Checksum:i3870201C3162C253
GO
Isoform e2 Publications (identifier: O62305-5) [UniParc]FASTAAdd to basket
Also known as: C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     350-364: VYPNVLLFNPQKFPR → GAILTTMIATRNLSN
     365-513: Missing.
     548-585: Missing.

Show »
Length:533
Mass (Da):59,537
Checksum:i0D8EF2D999E0B8AA
GO
Isoform f2 Publications (identifier: O62305-6) [UniParc]FASTAAdd to basket
Also known as: E1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-313: AAISAVKMVTRMSGV → GAILTTMIATRNLSS
     314-515: Missing.

Show »
Length:518
Mass (Da):58,067
Checksum:i14DA5EB06D2DAFF3
GO
Isoform g2 Publications (identifier: O62305-7) [UniParc]FASTAAdd to basket
Also known as: B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-314: AAISAVKMVTRMSGVL → GAILTTMIATRNLSNL
     315-514: Missing.

Show »
Length:520
Mass (Da):58,264
Checksum:i7D20BF318483E085
GO
Isoform h2 Publications (identifier: O62305-8) [UniParc]FASTAAdd to basket
Also known as: D1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     350-364: VYPNVLLFNPQKFPR → GAILTTMIATRNLSN
     365-513: Missing.

Show »
Length:571
Mass (Da):63,212
Checksum:i20C754B5BFE86D01
GO
Isoform i2 Publications (identifier: O62305-9) [UniParc]FASTAAdd to basket
Also known as: H1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-314: AAISAVKMVTRMSGVL → GAILTTMIATRNLSNL
     315-514: Missing.
     549-550: GG → NE
     551-720: Missing.

Show »
Length:350
Mass (Da):39,384
Checksum:iE300DB75FE74E9BC
GO
Isoform k2 Publications (identifier: O62305-10) [UniParc]FASTAAdd to basket
Also known as: F1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-302: AAIS → VVDS
     303-720: Missing.

Show »
Length:302
Mass (Da):34,198
Checksum:i5BCA124A7458DD9F
GO
Isoform l2 Publications (identifier: O62305-11) [UniParc]FASTAAdd to basket
Also known as: G1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     299-302: AAIS → VAIC
     303-720: Missing.

Show »
Length:302
Mass (Da):34,184
Checksum:i40C0FD5A7458DD9F
GO
Isoform m1 Publication (identifier: O62305-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-414: Missing.
     415-512: PYHCFTNKMS...VDNLSASTSS → MDGLLARLKL...KPEKLEVEAD

Note: No experimental confirmation available.Curated
Show »
Length:309
Mass (Da):34,103
Checksum:i13A93D058438BA8A
GO
Isoform n1 Publication (identifier: O62305-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-505: Missing.
     506-515: LSASTSSDLG → MNFLRFSGKC

Note: No experimental confirmation available.Curated
Show »
Length:215
Mass (Da):23,941
Checksum:i392E9298ABF7375D
GO
Isoform o1 Publication (identifier: O62305-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-416: Missing.
     417-514: HCFTNKMSNY...NLSASTSSDL → MDGLLARLKL...KPEKLEVEAD
     548-585: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:269
Mass (Da):30,200
Checksum:iD1B879B53DE0A973
GO
Isoform p1 Publication (identifier: O62305-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-504: Missing.
     505-513: NLSASTSSD → MIATRNLSN

Note: No experimental confirmation available.Curated
Show »
Length:216
Mass (Da):23,927
Checksum:i592578E5DE7DC6B4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0395901 – 505Missing in isoform n. 1 PublicationAdd BLAST505
Alternative sequenceiVSP_0395911 – 504Missing in isoform p. 1 PublicationAdd BLAST504
Alternative sequenceiVSP_0395921 – 490Missing in isoform a. 1 PublicationAdd BLAST490
Alternative sequenceiVSP_0395931 – 416Missing in isoform o. 1 PublicationAdd BLAST416
Alternative sequenceiVSP_0395941 – 414Missing in isoform m. 1 PublicationAdd BLAST414
Alternative sequenceiVSP_039595113 – 138HCIQQ…DLKPE → CCIMQILDGVNYCHQRGIVH RDMKV in isoform b. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_039596139 – 720Missing in isoform b. 1 PublicationAdd BLAST582
Alternative sequenceiVSP_039597299 – 314AAISA…MSGVL → GAILTTMIATRNLSNL in isoform d, isoform g and isoform i. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_039598299 – 313AAISA…RMSGV → GAILTTMIATRNLSS in isoform f. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_039599299 – 302AAIS → VVDS in isoform k. 2 Publications4
Alternative sequenceiVSP_039600299 – 302AAIS → VAIC in isoform l. 2 Publications4
Alternative sequenceiVSP_039601303 – 720Missing in isoform k and isoform l. 2 PublicationsAdd BLAST418
Alternative sequenceiVSP_039602314 – 515Missing in isoform f. 2 PublicationsAdd BLAST202
Alternative sequenceiVSP_039603315 – 514Missing in isoform d, isoform g and isoform i. 3 PublicationsAdd BLAST200
Alternative sequenceiVSP_039604350 – 364VYPNV…QKFPR → GAILTTMIATRNLSN in isoform e and isoform h. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_039605365 – 513Missing in isoform e and isoform h. 3 PublicationsAdd BLAST149
Alternative sequenceiVSP_039606415 – 512PYHCF…ASTSS → MDGLLARLKLGSKRKKKTSS SVKRSSRPESARQAPRDTTG SLYSNLTASSSTVSACSAPE IVVLKKEQVVLAVDHKDQVD EQKKKNEQVVKKPEKLEVEA D in isoform m. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_039607417 – 514HCFTN…TSSDL → MDGLLARLKLGSKRKKKTSS SVKRSSRPESARQAPRDTTG SLYSNLTASSSTVSACSAPE IVVLKKEQVVLAVDHKDQVD EQKKKNEQVVKKPEKLEVEA D in isoform o. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_039608491 – 515VVVAT…SSDLG → MKNIEYWQVLLNKIFATYKI KMKQC in isoform a. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_039609505 – 513NLSASTSSD → MIATRNLSN in isoform p. 1 Publication9
Alternative sequenceiVSP_039610506 – 515LSASTSSDLG → MNFLRFSGKC in isoform n. 1 Publication10
Alternative sequenceiVSP_039611548 – 585Missing in isoform d, isoform e and isoform o. 3 PublicationsAdd BLAST38
Alternative sequenceiVSP_039612549 – 550GG → NE in isoform i. 2 Publications2
Alternative sequenceiVSP_039613551 – 720Missing in isoform i. 2 PublicationsAdd BLAST170

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180735 mRNA. Translation: AAD53949.1.
AF233262 mRNA. Translation: AAF63320.1.
AF233263 mRNA. Translation: AAF63321.1.
AF233264 mRNA. Translation: AAF63322.1.
AF233265 mRNA. Translation: AAF63323.1.
AF233266 mRNA. Translation: AAF63324.1.
AF233267 mRNA. Translation: AAF63325.1.
AF255956 mRNA. Translation: AAF71543.1.
Z70279 Genomic DNA. Translation: CAA94242.3.
Z70279, AL023841 Genomic DNA. Translation: CAA94243.3.
Z70279, AL023841 Genomic DNA. Translation: CAC42322.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42323.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42324.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42325.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42326.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42327.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42328.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42329.1.
Z70279 Genomic DNA. Translation: CAE46679.1.
Z70279 Genomic DNA. Translation: CAN86910.1.
Z70279 Genomic DNA. Translation: CAO82047.1.
Z70279 Genomic DNA. Translation: CAQ58116.1.
PIRiB88809.
T23616.
RefSeqiNP_001023293.2. NM_001028122.4. [O62305-2]
NP_001023294.1. NM_001028123.3. [O62305-3]
NP_001023296.1. NM_001028125.3. [O62305-4]
NP_001023297.1. NM_001028126.3. [O62305-5]
NP_001023298.1. NM_001028127.3. [O62305-6]
NP_001023299.1. NM_001028128.3. [O62305-7]
NP_001023300.1. NM_001028129.3. [O62305-8]
NP_001023301.1. NM_001028130.3. [O62305-9]
NP_001023302.1. NM_001028131.3. [O62305-10]
NP_001023303.1. NM_001028132.3. [O62305-11]
NP_001023304.1. NM_001028133.4. [O62305-12]
NP_001122788.1. NM_001129316.2. [O62305-13]
NP_001122789.1. NM_001129317.2. [O62305-14]
NP_001129863.1. NM_001136391.2. [O62305-15]
UniGeneiCel.22903.

Genome annotation databases

GeneIDi177921.
UCSCiK11E8.1a.1. c. elegans.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180735 mRNA. Translation: AAD53949.1.
AF233262 mRNA. Translation: AAF63320.1.
AF233263 mRNA. Translation: AAF63321.1.
AF233264 mRNA. Translation: AAF63322.1.
AF233265 mRNA. Translation: AAF63323.1.
AF233266 mRNA. Translation: AAF63324.1.
AF233267 mRNA. Translation: AAF63325.1.
AF255956 mRNA. Translation: AAF71543.1.
Z70279 Genomic DNA. Translation: CAA94242.3.
Z70279, AL023841 Genomic DNA. Translation: CAA94243.3.
Z70279, AL023841 Genomic DNA. Translation: CAC42322.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42323.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42324.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42325.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42326.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42327.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42328.1.
Z70279, AL023841 Genomic DNA. Translation: CAC42329.1.
Z70279 Genomic DNA. Translation: CAE46679.1.
Z70279 Genomic DNA. Translation: CAN86910.1.
Z70279 Genomic DNA. Translation: CAO82047.1.
Z70279 Genomic DNA. Translation: CAQ58116.1.
PIRiB88809.
T23616.
RefSeqiNP_001023293.2. NM_001028122.4. [O62305-2]
NP_001023294.1. NM_001028123.3. [O62305-3]
NP_001023296.1. NM_001028125.3. [O62305-4]
NP_001023297.1. NM_001028126.3. [O62305-5]
NP_001023298.1. NM_001028127.3. [O62305-6]
NP_001023299.1. NM_001028128.3. [O62305-7]
NP_001023300.1. NM_001028129.3. [O62305-8]
NP_001023301.1. NM_001028130.3. [O62305-9]
NP_001023302.1. NM_001028131.3. [O62305-10]
NP_001023303.1. NM_001028132.3. [O62305-11]
NP_001023304.1. NM_001028133.4. [O62305-12]
NP_001122788.1. NM_001129316.2. [O62305-13]
NP_001122789.1. NM_001129317.2. [O62305-14]
NP_001129863.1. NM_001136391.2. [O62305-15]
UniGeneiCel.22903.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BDWX-ray1.80A/B1-543[»]
2F86X-ray2.64B/D/F/H/J/L/N540-720[»]
3KK8X-ray1.72A5-288[»]
3KK9X-ray3.21A6-287[»]
3KL8X-ray3.37A/C/E/G/I5-273[»]
ProteinModelPortaliO62305.
SMRiO62305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43023. 8 interactors.
DIPiDIP-25971N.
DIP-58986N.
IntActiO62305. 8 interactors.
MINTiMINT-115321.

PTM databases

iPTMnetiO62305.

Proteomic databases

EPDiO62305.
PeptideAtlasiO62305.
PRIDEiO62305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi177921.
UCSCiK11E8.1a.1. c. elegans.

Organism-specific databases

CTDi177921.
WormBaseiK11E8.1a; CE42693; WBGene00006779; unc-43.
K11E8.1b; CE28052; WBGene00006779; unc-43.
K11E8.1d; CE28054; WBGene00006779; unc-43.
K11E8.1e; CE28055; WBGene00006779; unc-43.
K11E8.1f; CE28056; WBGene00006779; unc-43.
K11E8.1g; CE28057; WBGene00006779; unc-43.
K11E8.1h; CE28058; WBGene00006779; unc-43.
K11E8.1i; CE28059; WBGene00006779; unc-43.
K11E8.1k; CE28060; WBGene00006779; unc-43.
K11E8.1l; CE28061; WBGene00006779; unc-43.
K11E8.1m; CE35590; WBGene00006779; unc-43.
K11E8.1n; CE40979; WBGene00006779; unc-43.
K11E8.1o; CE41430; WBGene00006779; unc-43.
K11E8.1p; CE42670; WBGene00006779; unc-43.

Phylogenomic databases

InParanoidiO62305.
PhylomeDBiO62305.

Enzyme and pathway databases

BRENDAi2.7.11.17. 1045.
SignaLinkiO62305.

Miscellaneous databases

EvolutionaryTraceiO62305.
PROiO62305.

Family and domain databases

Gene3Di3.10.450.50. 1 hit.
InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543. Ca/CaM-dep_prot_kinase-assoc.
IPR011009. Kinase-like_dom.
IPR032710. NTF2-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 2 hits.
PfamiPF08332. CaMKII_AD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCC2D_CAEEL
AccessioniPrimary (citable) accession number: O62305
Secondary accession number(s): A5JYT0
, A7LPH2, B3GWC8, O62304, Q21431, Q7JLT8, Q9NG91, Q9NH55, Q9NH56, Q9NH57, Q9NH58, Q9NH59, Q9NH60, Q9U6Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.