Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc metalloproteinase nas-1

Gene

nas-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Metalloprotease.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi162Zinc; catalyticPROSITE-ProRule annotation1
Active sitei163PROSITE-ProRule annotation1
Metal bindingi166Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi172Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM12.A14

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-1 (EC:3.4.24.-By similarity)
Alternative name(s):
Nematode astacin 1
Gene namesi
Name:nas-1
ORF Names:F45G2.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF45G2.1 ; CE33784 ; WBGene00003520 ; nas-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000028906? – 270Zinc metalloproteinase nas-1
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000044264918 – ?Curated

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiO62243

Expressioni

Gene expression databases

BgeeiWBGene00003520

Structurei

3D structure databases

ProteinModelPortaliO62243
SMRiO62243
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119227
HOGENOMiHOG000022037
InParanoidiO62243
KOiK08076
OMAiYAKRTCI
OrthoDBiEOG091G009U
PhylomeDBiO62243

Family and domain databases

CDDicd04280 ZnMc_astacin_like, 1 hit
Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR034035 Astacin-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00235 ZnMc, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O62243-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPIVVSILL ATPLALCQAP FWMPNMQQFS FLTETDFRNA LLLPTTNTRR
60 70 80 90 100
VRSLYHDMRI PFQRFKRGGG VAVAAEKDKW PNGRVPYILS AAYTSAQRAV
110 120 130 140 150
LARAFDTYAK RTCIRFVPKS PADKDYIVIQ KLDGCYADFS RVGGRQQVSL
160 170 180 190 200
ADECIDYATI IHELMHVIGF IHEHQREDRD SYVSILYQNV IQGANTDFDK
210 220 230 240 250
LSNLGLSYYG EHYDYSSIMH YEANEGSRNG KNTIEAKNSH FTAIMGKASD
260 270
FSTSDLRRVN RAYKCSIFAF
Length:270
Mass (Da):30,756
Last modified:June 1, 2003 - v2
Checksum:iF6F551EE966818CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93382 Genomic DNA Translation: CAB07610.2
PIRiT22233
RefSeqiNP_499768.2, NM_067367.6
UniGeneiCel.10469

Genome annotation databases

EnsemblMetazoaiF45G2.1; F45G2.1; WBGene00003520
GeneIDi185811
KEGGicel:CELE_F45G2.1
UCSCiF45G2.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiNAS1_CAEEL
AccessioniPrimary (citable) accession number: O62243
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health