O62218 (O62218_CAEEL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA polymerase RuleBase RU000442
EC=2.7.7.7 RuleBase RU000442

Gene names

ORF Names:

CELE_F33H2.5 EMBL CAB04263.1, F33H2.5 EMBL CAB04263.1 WormBase F33H2.5

Organism

Caenorhabditis elegans [Reference proteome] EMBL CAB04263.1

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	2144 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). RuleBase RU000442
Sequence similarities	Belongs to the DNA polymerase type-B family. RuleBase RU000442

Ontologies

Keywords
Biological process	DNA replication RuleBase RU000442
Ligand	DNA-binding RuleBase RU000442
Molecular function	DNA-directed DNA polymerase RuleBase RU000442 Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O62218 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: D73E820585EB1B75	FASTA	2,144	244,709
	10 20 30 40 50 60 MSSKDDILAQ AVENDSNYKE RLALIRSNDE IDAKLGFSRY TGLQEKKGFL INIQPSELVD 70 80 90 100 110 120 EQTKVIISVV DYFFISDMDE RFKISYPFRP YFYIATLDGF EFQVSSYLSK KYGAQTAVEH 130 140 150 160 170 180 MDREDLDLKD HLSGLKKTYI KLSFTSTVEL IKIRKELMPL VRKNTDRIKK ESAYADYLAR 190 200 210 220 230 240 NLSGKGGDSK DQQLNGDILN QIVDIREYDV PFHMRVSIDE KIFVGLWYDV KGIGPNRVPT 250 260 270 280 290 300 IKRKDLPLFH AKPKVLAFDI ETTKLPLKFP DRESDEIMMI SYMVDGRGFL IINREIVSAD 310 320 330 340 350 360 INAFEYTPKA EYIGEFTVWN EKDEAALIRK FFDHFLQVRP NIVVTYNGDF FDWPFVEARA 370 380 390 400 410 420 KIRGFNMERE IGFSKDSADE YKSRNCIHMD AFRWVKRDSY LPVGSQNLKA VTKAKLRYDP 430 440 450 460 470 480 VEVEPELMCK MAREQPQQLA NYSVSDAVST YYLYMKYVHQ FIFALCTIIP LGADDVLRKG 490 500 510 520 530 540 SGTLCEALLM VEAFHNNIVF PNKYTGPEET RFSKDGHRVE SETYVGGHVE ALEAGVFRAD 550 560 570 580 590 600 IPAKFRLSVP ALEQLKSEIQ ETLRKELARE FEVTLDQVVD FDEQCAEVQD AFDGMINVPT 610 620 630 640 650 660 RLENPRIYHL DVGAMYPNII LTNRLQPCAM VTEEICMGCS YNKPDAECKR TMAWEWRGEL 670 680 690 700 710 720 TPATRGEYQQ IMQQLEAESF GKPPKHFHML ERSEREAIEM KRIKDYSRRV YGKTHLTRLE 730 740 750 760 770 780 MRETTICQRE NHFYVETVKA FRDRRYEYKD MLKKAKGRFD QAQATNDLAT MTTSKLEMVL 790 800 810 820 830 840 YESLQLAHKC ILNSFYGYVM RKGSRWFSME MAGIVCHTGA NIIREARKLV EQIGTPLELD 850 860 870 880 890 900 TDGIWCLIPA SFPENVTFKL KNHKRSSVTV SYPGAMLNAL VYEGFTNHQY HTLEKDGSYS 910 920 930 940 950 960 KSSENSIYFE VDGPYQCMIL PASKEEGKKL KKRYAVFNLD GSLAEMKGFE LKRRGELNII 970 980 990 1000 1010 1020 KHFQGCVFKT FLNGKTLEET YKAVAADADH WLDILHSHGA DLTDEELFDL ISENRSMSRK 1030 1040 1050 1060 1070 1080 LEDYGAQKST SISTAKRLAE FLGDDMVKDA GLACMFIISK HPIGAPVTER AIPVAIFKSD 1090 1100 1110 1120 1130 1140 AKVRSHYIRK WTKQVDFNED TDIRDMLDWD YYLERFGSCI QKIITIPAAL QGISNPVPRV 1150 1160 1170 1180 1190 1200 PHPDWLQNKI RNKFDAHRQP RINQIFAACQ KPSTSQMDNG KRRRTPDDDV ASEDAMDSQD 1210 1220 1230 1240 1250 1260 DIIIDDDKEN GAKRQKNTKK VHTTEVVLEK KTLVEHGFDE WMGFLKKKWR VQRKERKTQL 1270 1280 1290 1300 1310 1320 SSKDSDVVEA IVRGAREAEH DKEWHILSVE PTADASFFNV WLAVQGQMHK VIMKIGRRII 1330 1340 1350 1360 1370 1380 VDSRAPRGDR DTIRRILPHH KTPGFLYEFR TDENQLTALM DKLYSETCSS TIDGIYESEV 1390 1400 1410 1420 1430 1440 PTSFRAVLQL GSIVRPDHGI SLGGHQLTLE NLKPMEKAPY LPLDQKIRTI FLYKFSQDSR 1450 1460 1470 1480 1490 1500 HVYSLIDSSG SAAYFYIVNT GDVQMPNMDS LYTSAYTKMM STERGQLCHT SESMPFTVKR 1510 1520 1530 1540 1550 1560 FSSNTECERQ LGRALRVYRE VSSKTAIVLL LSDTDPFRLA RKLPNLGLFP NVQLHITEPS 1570 1580 1590 1600 1610 1620 SLLNQIDWQK VVARRVLQHY FNSFFFLADY LEWARYLRVP IGNLPADHAL FGLDLLFARN 1630 1640 1650 1660 1670 1680 LQKSGHALWA TRASRPDLGG KEMDDVRLSV DWNPLSIDDT VLLNRETFCE TACVELQLSA 1690 1700 1710 1720 1730 1740 VAVTALVQRS RVLEAEGADD VVTFDSMNTI AQQSVTGGAV NSIACYDEGA AVDATIKVLK 1750 1760 1770 1780 1790 1800 QMLTECVRHI AHQGNARADE VVMTVSRWLN TRSALLFDAA LTRSVSVLES KLVLLLCAEC 1810 1820 1830 1840 1850 1860 ERIGAKVIHA TAQKLVLNTG KSTSEEAKGF AEMLIQSLST NVVFAALHIT PVKFFDAMLW 1870 1880 1890 1900 1910 1920 MDAHNHTGIR ISEKTESSPD VIADEEESSC TEFETTAIWK IAEEMPTEAN IQEEFLQMIG 1930 1940 1950 1960 1970 1980 AYILEFLETN RKMHFDSESG ATFRSDCISQ KISHRLYRIV NKMVHNNADI AHCSVYLANA 1990 2000 2010 2020 2030 2040 LCRALSCDQT SQLAVEGIRD NAKRLLHNSV VEADMTPLRS TTLFVSNVFC NSCSQASNVF 2050 2060 2070 2080 2090 2100 LSSTDEILTC ATCQSKLNSD VIDMMICDRL NQLLTAYQIQ DHQCTKCKSV RHDTLSMYCE 2110 2120 2130 2140 CCSQFIPQIT PAQLKHEAST VETVSIVRNF ALSSELATWV LKML

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." Caenorhabditis elegans Sequencing Consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2 EMBL CAB04263.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z81526 Genomic DNA. Translation: CAB04263.1.
PIR	T21712.
RefSeq	NP_493616.1. NM_061215.3.
3D structure databases
ProteinModelPortal	O62218.
SMR	O62218. Positions 82-573, 759-1039.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.F33H2.5. O62218.
Proteomic databases
PaxDb	O62218.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F33H2.5; F33H2.5; F33H2.5.
GeneID	173368.
KEGG	cel:CELE_F33H2.5.
UCSC	F33H2.5. c. elegans.
Organism-specific databases
CTD	173368.
WormBase	F33H2.5; CE17767; WBGene00009368.
Phylogenomic databases
eggNOG	COG0417.
GeneTree	ENSGT00390000010194.
HOGENOM	HOG000196287.
InParanoid	O62218.
KO	K02324.
OMA	QEESQDL.
Family and domain databases
InterPro	IPR006172. DNA-dir_DNA_pol_B. IPR006133. DNA-dir_DNA_pol_B_exonuc. IPR006134. DNA-dir_DNA_pol_B_multi_dom. IPR013697. DNA_pol_e_suA_C. IPR012337. RNaseH-like_dom. [Graphical view]
Pfam	PF00136. DNA_pol_B. 1 hit. PF03104. DNA_pol_B_exo1. 1 hit. PF08490. DUF1744. 1 hit. [Graphical view]
SMART	SM00486. POLBc. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	879359.

Entry information

Entry name

O62218_CAEEL

Accession

Primary (citable) accession number: O62218

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)