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Protein

Innexin-14

Gene

inx-14

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Structural component of the gap junctions.By similarity

GO - Molecular functioni

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • negative regulation of oocyte maturation Source: WormBase

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Protein family/group databases

TCDBi1.A.25.1.6. the gap junction-forming innexin (innexin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Innexin-14
Alternative name(s):
Protein opu-14
Gene namesi
Name:inx-14
Synonyms:opu-14
ORF Names:F07A5.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF07A5.1a; CE05554; WBGene00002136; inx-14.
F07A5.1b; CE17632; WBGene00002136; inx-14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei106 – 126HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei301 – 321HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei365 – 385HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002085141 – 434Innexin-14Add BLAST434

Proteomic databases

EPDiO62136.
PaxDbiO62136.
PeptideAtlasiO62136.
PRIDEiO62136.

Expressioni

Gene expression databases

BgeeiWBGene00002136.

Interactioni

Protein-protein interaction databases

BioGridi37930. 3 interactors.
DIPiDIP-24670N.
IntActiO62136. 1 interactor.
MINTiMINT-1065280.
STRINGi6239.F07A5.1b.

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3883. Eukaryota.
ENOG4110VES. LUCA.
GeneTreeiENSGT00530000064205.
InParanoidiO62136.
KOiK22037.
OMAiYLCADGI.
OrthoDBiEOG091G07W3.
PhylomeDBiO62136.

Family and domain databases

InterProiView protein in InterPro
IPR000990. Innexin.
PANTHERiPTHR11893. PTHR11893. 2 hits.
PfamiView protein in Pfam
PF00876. Innexin. 1 hit.
PRINTSiPR01262. INNEXIN.
PROSITEiView protein in PROSITE
PS51013. PANNEXIN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b (identifier: O62136-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIWEIPIIGD FITKPFKAAK LYEFYDRLHL FTVYLLGFFV LLTGAKQHFG
60 70 80 90 100
NPIDCMLPKQ HDDLKSWRDY IHNFCLFYGT FRYDVSNGTS EFGSYTEDAS
110 120 130 140 150
VNYYQWVPFF FAFQVCCFLL PFWCWAYMQK LIYIDMAFIV DYSGKINSEK
160 170 180 190 200
TFEKTKEKVD RIVNYMHDHF KFRRAHKMGY LSWITFNSAF PSVLYSLTKL
210 220 230 240 250
FFITNVIIQV NLVCKFLDVD SWTWGFDLLG KFIHPTPRAP EFSSFSDKQR
260 270 280 290 300
FAAILTDGSY NRFQYFPILV GCEYQLQESV SNFVNHKAQC IIPMNVINEK
310 320 330 340 350
IFIGLYFWLL VLTALSVIGT VKWILRIKSK KLNEVMIYKL IKKSLEREPF
360 370 380 390 400
DSNIHDHRYN FVHKYLCADG ILLIYFMMDT NGFLKTEEVI GALFKKYCSD
410 420 430
AGLEPLQTAP TLTSSPRDLA YSETNYGFAA PQKI
Length:434
Mass (Da):50,982
Last modified:August 1, 1998 - v1
Checksum:i6EEC58DB8295134E
GO
Isoform a (identifier: O62136-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-407: Missing.

Note: No experimental confirmation available.
Show »
Length:432
Mass (Da):50,741
Checksum:i69506DC6C3AD79A8
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002680406 – 407Missing in isoform a. Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72506 Genomic DNA. Translation: CAA96621.1.
Z72506 Genomic DNA. Translation: CAA96618.1.
PIRiT20536.
T20539.
RefSeqiNP_492078.1. NM_059677.6. [O62136-1]
NP_492079.1. NM_059678.5. [O62136-2]
UniGeneiCel.22679.

Genome annotation databases

EnsemblMetazoaiF07A5.1b; F07A5.1b; WBGene00002136. [O62136-1]
GeneIDi172488.
KEGGicel:CELE_F07A5.1.
UCSCiF07A5.1b. c. elegans. [O62136-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiINX14_CAEEL
AccessioniPrimary (citable) accession number: O62136
Secondary accession number(s): Q19139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families