Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Innexin-14

Gene

inx-14

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Structural components of the gap junctions.By similarity

GO - Molecular functioni

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • negative regulation of oocyte maturation Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.25.1.6. the gap junction-forming innexin (innexin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Innexin-14
Alternative name(s):
Protein opu-14
Gene namesi
Name:inx-14
Synonyms:opu-14
ORF Names:F07A5.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF07A5.1a; CE05554; WBGene00002136; inx-14.
F07A5.1b; CE17632; WBGene00002136; inx-14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei106 – 12621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei301 – 32121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei365 – 38521HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Innexin-14PRO_0000208514Add
BLAST

Proteomic databases

EPDiO62136.
PaxDbiO62136.
PRIDEiO62136.

Interactioni

Protein-protein interaction databases

BioGridi37930. 3 interactions.
DIPiDIP-24670N.
IntActiO62136. 1 interaction.
MINTiMINT-1065280.
STRINGi6239.F07A5.1b.

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3883. Eukaryota.
ENOG4110VES. LUCA.
GeneTreeiENSGT00530000064205.
InParanoidiO62136.
OMAiYLCADGI.
OrthoDBiEOG74N5G9.
PhylomeDBiO62136.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PANTHERiPTHR11893. PTHR11893. 2 hits.
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PRINTSiPR01262. INNEXIN.
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b (identifier: O62136-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIWEIPIIGD FITKPFKAAK LYEFYDRLHL FTVYLLGFFV LLTGAKQHFG
60 70 80 90 100
NPIDCMLPKQ HDDLKSWRDY IHNFCLFYGT FRYDVSNGTS EFGSYTEDAS
110 120 130 140 150
VNYYQWVPFF FAFQVCCFLL PFWCWAYMQK LIYIDMAFIV DYSGKINSEK
160 170 180 190 200
TFEKTKEKVD RIVNYMHDHF KFRRAHKMGY LSWITFNSAF PSVLYSLTKL
210 220 230 240 250
FFITNVIIQV NLVCKFLDVD SWTWGFDLLG KFIHPTPRAP EFSSFSDKQR
260 270 280 290 300
FAAILTDGSY NRFQYFPILV GCEYQLQESV SNFVNHKAQC IIPMNVINEK
310 320 330 340 350
IFIGLYFWLL VLTALSVIGT VKWILRIKSK KLNEVMIYKL IKKSLEREPF
360 370 380 390 400
DSNIHDHRYN FVHKYLCADG ILLIYFMMDT NGFLKTEEVI GALFKKYCSD
410 420 430
AGLEPLQTAP TLTSSPRDLA YSETNYGFAA PQKI
Length:434
Mass (Da):50,982
Last modified:August 1, 1998 - v1
Checksum:i6EEC58DB8295134E
GO
Isoform a (identifier: O62136-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-407: Missing.

Note: No experimental confirmation available.
Show »
Length:432
Mass (Da):50,741
Checksum:i69506DC6C3AD79A8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei406 – 4072Missing in isoform a. CuratedVSP_002680

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72506 Genomic DNA. Translation: CAA96621.1.
Z72506 Genomic DNA. Translation: CAA96618.1.
PIRiT20536.
T20539.
RefSeqiNP_492078.1. NM_059677.6. [O62136-1]
NP_492079.1. NM_059678.5. [O62136-2]
UniGeneiCel.22679.

Genome annotation databases

EnsemblMetazoaiF07A5.1b; F07A5.1b; WBGene00002136. [O62136-1]
GeneIDi172488.
KEGGicel:CELE_F07A5.1.
UCSCiF07A5.1b. c. elegans. [O62136-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72506 Genomic DNA. Translation: CAA96621.1.
Z72506 Genomic DNA. Translation: CAA96618.1.
PIRiT20536.
T20539.
RefSeqiNP_492078.1. NM_059677.6. [O62136-1]
NP_492079.1. NM_059678.5. [O62136-2]
UniGeneiCel.22679.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi37930. 3 interactions.
DIPiDIP-24670N.
IntActiO62136. 1 interaction.
MINTiMINT-1065280.
STRINGi6239.F07A5.1b.

Protein family/group databases

TCDBi1.A.25.1.6. the gap junction-forming innexin (innexin) family.

Proteomic databases

EPDiO62136.
PaxDbiO62136.
PRIDEiO62136.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF07A5.1b; F07A5.1b; WBGene00002136. [O62136-1]
GeneIDi172488.
KEGGicel:CELE_F07A5.1.
UCSCiF07A5.1b. c. elegans. [O62136-1]

Organism-specific databases

CTDi172488.
WormBaseiF07A5.1a; CE05554; WBGene00002136; inx-14.
F07A5.1b; CE17632; WBGene00002136; inx-14.

Phylogenomic databases

eggNOGiKOG3883. Eukaryota.
ENOG4110VES. LUCA.
GeneTreeiENSGT00530000064205.
InParanoidiO62136.
OMAiYLCADGI.
OrthoDBiEOG74N5G9.
PhylomeDBiO62136.

Miscellaneous databases

PROiO62136.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PANTHERiPTHR11893. PTHR11893. 2 hits.
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PRINTSiPR01262. INNEXIN.
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiINX14_CAEEL
AccessioniPrimary (citable) accession number: O62136
Secondary accession number(s): Q19139
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.