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Protein

Eukaryotic translation initiation factor 6

Gene

eif-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing (PubMed:17507929).UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:eif-6UniRule annotation
ORF Names:C47B2.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC47B2.5; CE17565; WBGene00001234; eif-6.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleusnucleolus UniRule annotation

  • Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537361 – 246Eukaryotic translation initiation factor 6Add BLAST246

Proteomic databases

EPDiO62106.
PaxDbiO62106.
PeptideAtlasiO62106.
PRIDEiO62106.

PTM databases

iPTMnetiO62106.

Expressioni

Gene expression databases

BgeeiWBGene00001234.

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

IntActiO62106. 2 interactors.
STRINGi6239.C47B2.5.2.

Structurei

3D structure databases

ProteinModelPortaliO62106.
SMRiO62106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
GeneTreeiENSGT00390000015972.
HOGENOMiHOG000230605.
InParanoidiO62106.
KOiK03264.
OMAiNDWCAFT.
OrthoDBiEOG091G0HYF.
PhylomeDBiO62106.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

O62106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRVDYEGS NDVGVFCTLT NSYCLVGVGG TQNFYSILEA ELSDLIPVVH
60 70 80 90 100
TSIASTRIVG RLTVGNRHGL LVPNATTDQE LQHLRNSLPD EVAIRRVDER
110 120 130 140 150
LSALGNVIAC NDHVAIVHAE ISAETEQALV EVLKVEVFRV SLAQNSLVGS
160 170 180 190 200
YCILSSNGCL VAARTPPETQ REIAALLQIP VVAGTCNRGS ELIGAGMVVN
210 220 230 240
DWVAFCGLDS TSTELSVVES IFKLGEQGAP TSISNQLRDT LIESML
Length:246
Mass (Da):26,308
Last modified:August 1, 1998 - v1
Checksum:iD9DEAA42AE990253
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99709 Genomic DNA. Translation: CAB16860.1.
PIRiT19988.
RefSeqiNP_493272.1. NM_060871.5.
UniGeneiCel.5049.

Genome annotation databases

EnsemblMetazoaiC47B2.5.1; C47B2.5.1; WBGene00001234.
C47B2.5.2; C47B2.5.2; WBGene00001234.
GeneIDi173169.
KEGGicel:CELE_C47B2.5.
UCSCiC47B2.5.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99709 Genomic DNA. Translation: CAB16860.1.
PIRiT19988.
RefSeqiNP_493272.1. NM_060871.5.
UniGeneiCel.5049.

3D structure databases

ProteinModelPortaliO62106.
SMRiO62106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO62106. 2 interactors.
STRINGi6239.C47B2.5.2.

PTM databases

iPTMnetiO62106.

Proteomic databases

EPDiO62106.
PaxDbiO62106.
PeptideAtlasiO62106.
PRIDEiO62106.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC47B2.5.1; C47B2.5.1; WBGene00001234.
C47B2.5.2; C47B2.5.2; WBGene00001234.
GeneIDi173169.
KEGGicel:CELE_C47B2.5.
UCSCiC47B2.5.1. c. elegans.

Organism-specific databases

CTDi173169.
WormBaseiC47B2.5; CE17565; WBGene00001234; eif-6.

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
GeneTreeiENSGT00390000015972.
HOGENOMiHOG000230605.
InParanoidiO62106.
KOiK03264.
OMAiNDWCAFT.
OrthoDBiEOG091G0HYF.
PhylomeDBiO62106.

Miscellaneous databases

PROiO62106.

Gene expression databases

BgeeiWBGene00001234.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIF6_CAEEL
AccessioniPrimary (citable) accession number: O62106
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.