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Protein

Proteasome subunit beta type

Gene

pbs-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine proteaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-6798695. Neutrophil degranulation.
R-CEL-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta typeUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
Name:pbs-2Imported
ORF Names:C47B2.4Imported, CELE_C47B2.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC47B2.4; CE17564; WBGene00003948; pbs-2.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation
  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation, ProteasomeUniRule annotationImported

PTM / Processingi

Proteomic databases

EPDiO62102.
PaxDbiO62102.
PeptideAtlasiO62102.

Expressioni

Gene expression databases

BgeeiWBGene00003948.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.UniRule annotation

Protein-protein interaction databases

IntActiO62102. 2 interactors.
MINTiMINT-211276.
STRINGi6239.C47B2.4.

Structurei

3D structure databases

ProteinModelPortaliO62102.
SMRiO62102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0173. Eukaryota.
COG0638. LUCA.
GeneTreeiENSGT00510000046533.
HOGENOMiHOG000182856.
InParanoidiO62102.
KOiK02739.
OMAiDHIYCCG.
OrthoDBiEOG091G0E5S.
PhylomeDBiO62102.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O62102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATADVKSTV PHMDMDRGGA FDFSNCIRNQ AMCKMGGKAP KLTSTGTTIV
60 70 80 90 100
AVAFKGGLVM GADSRATAGN IIADKHCEKV HKLTESIYAC GAGTAADLDQ
110 120 130 140 150
VTKMLSGNLR LLELNTGRKA RVITALRQAK QHLFNYQGYI GAYLLIGGVD
160 170 180 190 200
PTGPHLYMCS ANGTTMAFPF TAQGSGSYAA ITILERDFKV DMTKDEAEKL
210 220 230 240 250
VQRALEAGMH GDNASGNSLN LVIIEPSETV FKGPIVPEFC KRPEPNDLVY
260 270
KFQAGATKVL KHKTYKYDVV ESMDITH
Length:277
Mass (Da):29,861
Last modified:August 1, 1998 - v1
Checksum:iA0FCD28F390DB551
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB16855.1.
PIRiT19983.
RefSeqiNP_493271.1. NM_060870.3.
UniGeneiCel.23266.

Genome annotation databases

EnsemblMetazoaiC47B2.4; C47B2.4; WBGene00003948.
GeneIDi173168.
KEGGicel:CELE_C47B2.4.
UCSCiC47B2.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB16855.1.
PIRiT19983.
RefSeqiNP_493271.1. NM_060870.3.
UniGeneiCel.23266.

3D structure databases

ProteinModelPortaliO62102.
SMRiO62102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO62102. 2 interactors.
MINTiMINT-211276.
STRINGi6239.C47B2.4.

Protein family/group databases

MEROPSiT01.011.

Proteomic databases

EPDiO62102.
PaxDbiO62102.
PeptideAtlasiO62102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC47B2.4; C47B2.4; WBGene00003948.
GeneIDi173168.
KEGGicel:CELE_C47B2.4.
UCSCiC47B2.4. c. elegans.

Organism-specific databases

CTDi173168.
WormBaseiC47B2.4; CE17564; WBGene00003948; pbs-2.

Phylogenomic databases

eggNOGiKOG0173. Eukaryota.
COG0638. LUCA.
GeneTreeiENSGT00510000046533.
HOGENOMiHOG000182856.
InParanoidiO62102.
KOiK02739.
OMAiDHIYCCG.
OrthoDBiEOG091G0E5S.
PhylomeDBiO62102.

Enzyme and pathway databases

ReactomeiR-CEL-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-6798695. Neutrophil degranulation.
R-CEL-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

BgeeiWBGene00003948.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO62102_CAEEL
AccessioniPrimary (citable) accession number: O62102
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.