Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor elt-7

Gene

elt-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' (PubMed:26700680). Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-2 to control normal gene expression and promote normal formation of the intestine (PubMed:20807527, PubMed:24257624). May have a protective role in response to infection by Gram-negative bacteria such as P.aeruginosa (PubMed:21168435).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri143 – 167GATA-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: GO_Central
  • cell development Source: GO_Central
  • defense response to Gram-negative bacterium Source: WormBase
  • digestive tract development Source: GO_Central
  • endodermal cell fate determination Source: WormBase
  • heart development Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor elt-7Curated
Gene namesi
Name:elt-7Imported
ORF Names:C18G1.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC18G1.2a; CE17418; WBGene00015981; elt-7.
C18G1.2b; CE41205; WBGene00015981; elt-7.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: WormBase
  • transcription factor complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No obvious phenotype (PubMed:20807527). RNAi-mediated knockdown results in no obvious phenotype (PubMed:18448117). Following infection with P.aeruginosa, RNAi-mediated knockdown results in reduced survival and slight intestinal distension (PubMed:21168435). Double mutation with elt-2 results in arrest at the L1 stage of larval development, reduced expression of gut-specific genes and a severe disruption to normal gut differentiation with the absence of birefringent and rhabditin granules, which are characteristic of normal gut differentiation, largely at the regions of the cell that interface with the pharyngeal and rectal valves (PubMed:20807527). These mutants also have essentially no gut lumen, with only infrequent patches of lumen and brush border in few animals, and reduced gut epithelialization as indicated by reduced expression of epithelial markers erm-1b, itx-1 and ajm-1 (PubMed:20807527).3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004357241 – 198Transcription factor elt-7CuratedAdd BLAST198

Proteomic databases

PaxDbiA6PVB2.
O61924.

Expressioni

Developmental stagei

Expressed highly during embryogenesis. Expressed in the endoderm in cells of the gut lineage beginning at the 2E cell stage (endodermal cell stage) of embryogenesis through to adulthood.1 Publication

Inductioni

Induced by P.aeruginosa infection.1 Publication

Gene expression databases

BgeeiWBGene00015981.
ExpressionAtlasiO61924. differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiO61924. 22 interactors.
STRINGi6239.C18G1.2a.

Structurei

3D structure databases

ProteinModelPortaliO61924.
SMRiO61924.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 GATA-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri143 – 167GATA-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00730000112284.
HOGENOMiHOG000018718.
InParanoidiO61924.
OMAiLECNACN.
OrthoDBiEOG091G16VW.
PhylomeDBiO61924.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR028440. TRPS1/Elt-7.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF176. PTHR10071:SF176. 2 hits.
PfamiPF00320. GATA. 1 hit.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 1 hit.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 1 hit.
PS50114. GATA_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform aImported (identifier: O61924-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPETTTLQP LPSVTTIMNE PPARSPMEDY YLFNQFQYNQ NPYVYPPQPV
60 70 80 90 100
YYNTWQDAST HHFDPFQSYQ IPSPYEQPIQ SSMCTTPLQP LEDSRIIFDE
110 120 130 140 150
SLTKNENEQK SFVEQDSSYE SSGNRFGSQK GKKIAKVIRD ACCSHCSTTT
160 170 180 190
TTLWRKNDEG NLECNACNLY YRHNKVKRPL SLCKQKPTTR KRRQAKKE
Length:198
Mass (Da):23,097
Last modified:August 1, 1998 - v1
Checksum:iFA877E99888DD46D
GO
Isoform bImported (identifier: O61924-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:116
Mass (Da):13,407
Checksum:i75FF91C08CF5C1A3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0581561 – 82Missing in isoform b. CuratedAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD65225.1.
BX284605 Genomic DNA. Translation: CCD65231.1.
PIRiT33255.
RefSeqiNP_001122856.1. NM_001129384.3. [O61924-2]
NP_504283.1. NM_071882.5. [O61924-1]
UniGeneiCel.4704.

Genome annotation databases

EnsemblMetazoaiC18G1.2a; C18G1.2a; WBGene00015981. [O61924-1]
C18G1.2b; C18G1.2b; WBGene00015981. [O61924-2]
GeneIDi178868.
KEGGicel:CELE_C18G1.2.
UCSCiC18G1.2a. c. elegans.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CCD65225.1.
BX284605 Genomic DNA. Translation: CCD65231.1.
PIRiT33255.
RefSeqiNP_001122856.1. NM_001129384.3. [O61924-2]
NP_504283.1. NM_071882.5. [O61924-1]
UniGeneiCel.4704.

3D structure databases

ProteinModelPortaliO61924.
SMRiO61924.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO61924. 22 interactors.
STRINGi6239.C18G1.2a.

Proteomic databases

PaxDbiA6PVB2.
O61924.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC18G1.2a; C18G1.2a; WBGene00015981. [O61924-1]
C18G1.2b; C18G1.2b; WBGene00015981. [O61924-2]
GeneIDi178868.
KEGGicel:CELE_C18G1.2.
UCSCiC18G1.2a. c. elegans.

Organism-specific databases

CTDi178868.
WormBaseiC18G1.2a; CE17418; WBGene00015981; elt-7.
C18G1.2b; CE41205; WBGene00015981; elt-7.

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00730000112284.
HOGENOMiHOG000018718.
InParanoidiO61924.
OMAiLECNACN.
OrthoDBiEOG091G16VW.
PhylomeDBiO61924.

Miscellaneous databases

PROiO61924.

Gene expression databases

BgeeiWBGene00015981.
ExpressionAtlasiO61924. differential.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR028440. TRPS1/Elt-7.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF176. PTHR10071:SF176. 2 hits.
PfamiPF00320. GATA. 1 hit.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 1 hit.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 1 hit.
PS50114. GATA_ZN_FINGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELT7_CAEEL
AccessioniPrimary (citable) accession number: O61924
Secondary accession number(s): A6PVB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 16, 2016
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.