Reviewed, UniProtKB/Swiss-Prot O61856 (ILVBL_CAEEL)

Names and origin

Protein names

Recommended name:
    Acetolactate synthase-like protein
    EC=2.2.1.-
Alternative name(s):
    IlvB-like protein

Gene names

ORF Names:

T26C12.1

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	640 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Cofactor	Binds 1 magnesium ion per subunit By similarity. Binds 1 thiamine pyrophosphate per subunit By similarity.
Subcellular location	Membrane; Single-pass membrane protein.
Sequence similarities	Belongs to the TPP enzyme family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Ligand	Magnesium Metal-binding Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW thiamin pyrophosphate binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 640	640	Acetolactate synthase-like protein		PRO_0000314829
Regions
	Transmembrane	2 – 22	21	Potential
	Region	477 – 557	81	Thiamine pyrophosphate binding By similarity
Sites
	Metal binding	528	1	Magnesium By similarity
	Metal binding	554	1	Magnesium By similarity
	Binding site	102	1	Thiamine pyrophosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O61856-1 [UniParc]. Last modified October 1, 2001. Version 2. Checksum: D5F793843BF923C8	FASTA	640	69,263
	10 20 30 40 50 60 MVLFLIIAAI IIGLLLWKWL DVRSTDELTS MVKLLGSGNG QHVLSNAFQV DEKSKRHGGE 70 80 90 100 110 120 LVASVLKAHD VEEIFVLCGG HISPILVAAE KLGIKIVDTR HEVTAVFAAD AVARLRQSIG 130 140 150 160 170 180 VAAVTAGPGL TNTITAVKNA QMAESPLLLI GGAAPTLLKG RGALQDIDQM VLFRPLCKYV 190 200 210 220 230 240 ARVERLRDIV PTVREAIKAA KSGCPGPVFV EFPVDVLYPY ELVVKEIGFN PNAKGFIQRA 250 260 270 280 290 300 LNFYLRCHVS RQFGNAWAPQ TITPLPTNIP MPKSEKIQEI VQLVKSAKRP VLLIGSQATL 310 320 330 340 350 360 PPVKPADLVK AVEALGCPVF LGGMARGLLG KDHPLQMRQV RRDALKDADL TILAGTVCDF 370 380 390 400 410 420 RLSYGRTLSK KSKIVALNRN SSQLTKNEKA FWNSDVSVQA DVATSLVQVA NALGANHTTT 430 440 450 460 470 480 PTEWVKSLRE KDDEKESANA KKMEQKLTNG FLNPLNFLRT LDQSLPDDAI LVADGGDFVG 490 500 510 520 530 540 SAAYIVRPRG PLQWLDPGAF GTLGVGGGFA LGAKTVYPKR PVYIIWGDGS CGYSLMEYDT 550 560 570 580 590 600 FARHKLPVIG IVGNDACWTQ IAREQVPMFQ SSVAVDLART RYDNVAKSLG SWGETIDESN 610 620 630 640 ADSARKILDE ALAVCRSGEQ SALVNVLIGK TDFREGSISV

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF067623 Genomic DNA. Translation: AAC17553.2.
PIR	T33164.
RefSeq	NP_500306.1.
UniGene	Cel.5694
3D structure databases
HSSP	HSSP built from PDB template 1OZH based on UniProtKB P27696.
ModBase	Search...
Genome annotation databases
Ensembl	T26C12.1. Caenorhabditis elegans. [Contig view]
GeneID	177095.
KEGG	cel:T26C12.1.
Organism-specific databases
WormBase	WBGene00020831. T26C12.1.
WormPep	T26C12.1. CE26009. [WorfDB]
Phylogenomic databases
OMA	O61856. SLFRPLC.
Gene expression databases
ArrayExpress	O61856.
Family and domain databases
InterPro	IPR000399. TPP_bd_CS. IPR012001. TPP_bd_enzyme_N. IPR011766. TPP_enzyme_bd_C. IPR012000. TPP_enzyme_M. [Graphical view]
Pfam	PF02775. TPP_enzyme_C. 1 hit. PF00205. TPP_enzyme_M. 1 hit. PF02776. TPP_enzyme_N. 1 hit. [Graphical view]
PROSITE	PS00187. TPP_ENZYMES. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	895312.

Entry information

Entry name

ILVBL_CAEEL

Accession

Primary (citable) accession number: O61856

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 1, 2001
Last modified:	June 16, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project