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O61820

- EIF3E_CAEEL

UniProt

O61820 - EIF3E_CAEEL

Protein

Eukaryotic translation initiation factor 3 subunit E

Gene

eif-3.E

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

    GO - Molecular functioni

    1. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
    2. regulation of translational initiation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit EUniRule annotation
    Short name:
    eIF3eUniRule annotation
    Alternative name(s):
    Eukaryotic translation initiation factor 3 subunit 6UniRule annotation
    Gene namesi
    Name:eif-3.EUniRule annotation
    ORF Names:B0511.10
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiB0511.10; CE17349; WBGene00001228; eif-3.E.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
    2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
    3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432Eukaryotic translation initiation factor 3 subunit EPRO_0000123518Add
    BLAST

    Proteomic databases

    PaxDbiO61820.

    Interactioni

    Subunit structurei

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

    Protein-protein interaction databases

    BioGridi38371. 1 interaction.
    IntActiO61820. 2 interactions.
    STRINGi6239.B0511.10.

    Structurei

    3D structure databases

    ProteinModelPortaliO61820.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini288 – 394107PCIUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eIF-3 subunit E family.UniRule annotation
    Contains 1 PCI domain.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG324642.
    GeneTreeiENSGT00390000002661.
    HOGENOMiHOG000036697.
    InParanoidiO61820.
    KOiK03250.
    OMAiDILTGKW.
    PhylomeDBiO61820.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    HAMAPiMF_03004. eIF3e.
    InterProiIPR016650. eIF3e.
    IPR019010. eIF3e_N.
    IPR000717. PCI_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10317. PTHR10317. 1 hit.
    PfamiPF09440. eIF3_N. 1 hit.
    PF01399. PCI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016255. eIF3e_su6. 1 hit.
    SMARTiSM00088. PINT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O61820-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTFDLTQRM APFLDLHLII PLLEFIEPRG IYDEKSLTEM HRQLLTKTNM    50
    IDSVIETYNG KPIPAAIEAK KKQIIKERDE LKSKVDSVVA ILEIPEVKEM 100
    MDNNRERDGN VRILEHLTQN HNFTVDMVDT LFKYSKFMYE CGNYTVASVC 150
    LYYYRNLVNQ ADPNYLNALY GKLASEILLQ EWEHARDDLL KLRAYIDANP 200
    FDTEWELVTQ RAWLMHWALF VYYNYPKGRD EIIEMFLNQQ PYLNAIQVLA 250
    PHLLRYLAVA VVTSKSRQKN SLKDLVKVID IERHSYKDPV TDFLTCLYIK 300
    YDFDEAQEML QKCEEVLSND FFLTAVLGDF RESARLLIFE MFCRIHQCIT 350
    IEMLARRLNM SQEEAERWIV DLIRTYRIEG AKIDSKLGQV VMGVKSVSIH 400
    EQVMENTKRL TLRAQQIALQ LEKGRQDKVK AT 432
    Length:432
    Mass (Da):50,720
    Last modified:August 1, 1998 - v1
    Checksum:i5489E810F201633F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080219 Genomic DNA. Translation: CCD62105.1.
    PIRiT33118.
    RefSeqiNP_492785.1. NM_060384.6.
    UniGeneiCel.22775.

    Genome annotation databases

    EnsemblMetazoaiB0511.10; B0511.10; WBGene00001228.
    GeneIDi172959.
    KEGGicel:CELE_B0511.10.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080219 Genomic DNA. Translation: CCD62105.1 .
    PIRi T33118.
    RefSeqi NP_492785.1. NM_060384.6.
    UniGenei Cel.22775.

    3D structure databases

    ProteinModelPortali O61820.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 38371. 1 interaction.
    IntActi O61820. 2 interactions.
    STRINGi 6239.B0511.10.

    Proteomic databases

    PaxDbi O61820.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai B0511.10 ; B0511.10 ; WBGene00001228 .
    GeneIDi 172959.
    KEGGi cel:CELE_B0511.10.

    Organism-specific databases

    CTDi 172959.
    WormBasei B0511.10 ; CE17349 ; WBGene00001228 ; eif-3.E.

    Phylogenomic databases

    eggNOGi NOG324642.
    GeneTreei ENSGT00390000002661.
    HOGENOMi HOG000036697.
    InParanoidi O61820.
    KOi K03250.
    OMAi DILTGKW.
    PhylomeDBi O61820.

    Miscellaneous databases

    NextBioi 877691.
    PROi O61820.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    HAMAPi MF_03004. eIF3e.
    InterProi IPR016650. eIF3e.
    IPR019010. eIF3e_N.
    IPR000717. PCI_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10317. PTHR10317. 1 hit.
    Pfami PF09440. eIF3_N. 1 hit.
    PF01399. PCI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016255. eIF3e_su6. 1 hit.
    SMARTi SM00088. PINT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiEIF3E_CAEEL
    AccessioniPrimary (citable) accession number: O61820
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Translation initiation factors
      List of translation initiation factor entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3