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Protein

Eukaryotic translation initiation factor 3 subunit E

Gene

eif-3.E

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiREACT_295389. Ribosomal scanning and start codon recognition.
REACT_333089. Formation of a pool of free 40S subunits.
REACT_333124. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_344834. Formation of the ternary complex, and subsequently, the 43S complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit EUniRule annotation
Short name:
eIF3eUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6UniRule annotation
Gene namesi
Name:eif-3.EUniRule annotation
ORF Names:B0511.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiB0511.10; CE17349; WBGene00001228; eif-3.E.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Eukaryotic translation initiation factor 3 subunit EPRO_0000123518Add
BLAST

Proteomic databases

PaxDbiO61820.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

BioGridi38371. 1 interaction.
IntActiO61820. 2 interactions.
STRINGi6239.B0511.10.2.

Structurei

3D structure databases

ProteinModelPortaliO61820.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini288 – 394107PCIUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit E family.UniRule annotation
Contains 1 PCI domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG324642.
GeneTreeiENSGT00390000002661.
HOGENOMiHOG000036697.
InParanoidiO61820.
KOiK03250.
OMAiKEKRTEV.
PhylomeDBiO61820.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03004. eIF3e.
InterProiIPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10317. PTHR10317. 1 hit.
PfamiPF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
PIRSFiPIRSF016255. eIF3e_su6. 1 hit.
SMARTiSM00088. PINT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTFDLTQRM APFLDLHLII PLLEFIEPRG IYDEKSLTEM HRQLLTKTNM
60 70 80 90 100
IDSVIETYNG KPIPAAIEAK KKQIIKERDE LKSKVDSVVA ILEIPEVKEM
110 120 130 140 150
MDNNRERDGN VRILEHLTQN HNFTVDMVDT LFKYSKFMYE CGNYTVASVC
160 170 180 190 200
LYYYRNLVNQ ADPNYLNALY GKLASEILLQ EWEHARDDLL KLRAYIDANP
210 220 230 240 250
FDTEWELVTQ RAWLMHWALF VYYNYPKGRD EIIEMFLNQQ PYLNAIQVLA
260 270 280 290 300
PHLLRYLAVA VVTSKSRQKN SLKDLVKVID IERHSYKDPV TDFLTCLYIK
310 320 330 340 350
YDFDEAQEML QKCEEVLSND FFLTAVLGDF RESARLLIFE MFCRIHQCIT
360 370 380 390 400
IEMLARRLNM SQEEAERWIV DLIRTYRIEG AKIDSKLGQV VMGVKSVSIH
410 420 430
EQVMENTKRL TLRAQQIALQ LEKGRQDKVK AT
Length:432
Mass (Da):50,720
Last modified:August 1, 1998 - v1
Checksum:i5489E810F201633F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080219 Genomic DNA. Translation: CCD62105.1.
PIRiT33118.
RefSeqiNP_492785.1. NM_060384.6.
UniGeneiCel.22775.

Genome annotation databases

EnsemblMetazoaiB0511.10; B0511.10; WBGene00001228.
GeneIDi172959.
KEGGicel:CELE_B0511.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080219 Genomic DNA. Translation: CCD62105.1.
PIRiT33118.
RefSeqiNP_492785.1. NM_060384.6.
UniGeneiCel.22775.

3D structure databases

ProteinModelPortaliO61820.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38371. 1 interaction.
IntActiO61820. 2 interactions.
STRINGi6239.B0511.10.2.

Proteomic databases

PaxDbiO61820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0511.10; B0511.10; WBGene00001228.
GeneIDi172959.
KEGGicel:CELE_B0511.10.

Organism-specific databases

CTDi172959.
WormBaseiB0511.10; CE17349; WBGene00001228; eif-3.E.

Phylogenomic databases

eggNOGiNOG324642.
GeneTreeiENSGT00390000002661.
HOGENOMiHOG000036697.
InParanoidiO61820.
KOiK03250.
OMAiKEKRTEV.
PhylomeDBiO61820.

Enzyme and pathway databases

ReactomeiREACT_295389. Ribosomal scanning and start codon recognition.
REACT_333089. Formation of a pool of free 40S subunits.
REACT_333124. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_344834. Formation of the ternary complex, and subsequently, the 43S complex.

Miscellaneous databases

NextBioi877691.
PROiO61820.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03004. eIF3e.
InterProiIPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10317. PTHR10317. 1 hit.
PfamiPF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
PIRSFiPIRSF016255. eIF3e_su6. 1 hit.
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiEIF3E_CAEEL
AccessioniPrimary (citable) accession number: O61820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: July 22, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.