Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O61820

- EIF3E_CAEEL

UniProt

O61820 - EIF3E_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Eukaryotic translation initiation factor 3 subunit E

Gene

eif-3.E

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
  2. regulation of translational initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiREACT_230886. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_236035. Ribosomal scanning and start codon recognition.
REACT_237099. Formation of a pool of free 40S subunits.
REACT_259255. Formation of the ternary complex, and subsequently, the 43S complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit EUniRule annotation
Short name:
eIF3eUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6UniRule annotation
Gene namesi
Name:eif-3.EUniRule annotation
ORF Names:B0511.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiB0511.10; CE17349; WBGene00001228; eif-3.E.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
  2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Eukaryotic translation initiation factor 3 subunit EPRO_0000123518Add
BLAST

Proteomic databases

PaxDbiO61820.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

BioGridi38371. 1 interaction.
IntActiO61820. 2 interactions.
STRINGi6239.B0511.10.

Structurei

3D structure databases

ProteinModelPortaliO61820.
SMRiO61820. Positions 327-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini288 – 394107PCIUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit E family.UniRule annotation
Contains 1 PCI domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG324642.
GeneTreeiENSGT00390000002661.
HOGENOMiHOG000036697.
InParanoidiO61820.
KOiK03250.
OMAiDILTGKW.
PhylomeDBiO61820.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03004. eIF3e.
InterProiIPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10317. PTHR10317. 1 hit.
PfamiPF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
PIRSFiPIRSF016255. eIF3e_su6. 1 hit.
SMARTiSM00088. PINT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61820-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTFDLTQRM APFLDLHLII PLLEFIEPRG IYDEKSLTEM HRQLLTKTNM
60 70 80 90 100
IDSVIETYNG KPIPAAIEAK KKQIIKERDE LKSKVDSVVA ILEIPEVKEM
110 120 130 140 150
MDNNRERDGN VRILEHLTQN HNFTVDMVDT LFKYSKFMYE CGNYTVASVC
160 170 180 190 200
LYYYRNLVNQ ADPNYLNALY GKLASEILLQ EWEHARDDLL KLRAYIDANP
210 220 230 240 250
FDTEWELVTQ RAWLMHWALF VYYNYPKGRD EIIEMFLNQQ PYLNAIQVLA
260 270 280 290 300
PHLLRYLAVA VVTSKSRQKN SLKDLVKVID IERHSYKDPV TDFLTCLYIK
310 320 330 340 350
YDFDEAQEML QKCEEVLSND FFLTAVLGDF RESARLLIFE MFCRIHQCIT
360 370 380 390 400
IEMLARRLNM SQEEAERWIV DLIRTYRIEG AKIDSKLGQV VMGVKSVSIH
410 420 430
EQVMENTKRL TLRAQQIALQ LEKGRQDKVK AT
Length:432
Mass (Da):50,720
Last modified:August 1, 1998 - v1
Checksum:i5489E810F201633F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080219 Genomic DNA. Translation: CCD62105.1.
PIRiT33118.
RefSeqiNP_492785.1. NM_060384.6.
UniGeneiCel.22775.

Genome annotation databases

EnsemblMetazoaiB0511.10; B0511.10; WBGene00001228.
GeneIDi172959.
KEGGicel:CELE_B0511.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080219 Genomic DNA. Translation: CCD62105.1 .
PIRi T33118.
RefSeqi NP_492785.1. NM_060384.6.
UniGenei Cel.22775.

3D structure databases

ProteinModelPortali O61820.
SMRi O61820. Positions 327-398.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 38371. 1 interaction.
IntActi O61820. 2 interactions.
STRINGi 6239.B0511.10.

Proteomic databases

PaxDbi O61820.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0511.10 ; B0511.10 ; WBGene00001228 .
GeneIDi 172959.
KEGGi cel:CELE_B0511.10.

Organism-specific databases

CTDi 172959.
WormBasei B0511.10 ; CE17349 ; WBGene00001228 ; eif-3.E.

Phylogenomic databases

eggNOGi NOG324642.
GeneTreei ENSGT00390000002661.
HOGENOMi HOG000036697.
InParanoidi O61820.
KOi K03250.
OMAi DILTGKW.
PhylomeDBi O61820.

Enzyme and pathway databases

Reactomei REACT_230886. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_236035. Ribosomal scanning and start codon recognition.
REACT_237099. Formation of a pool of free 40S subunits.
REACT_259255. Formation of the ternary complex, and subsequently, the 43S complex.

Miscellaneous databases

NextBioi 877691.
PROi O61820.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_03004. eIF3e.
InterProi IPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10317. PTHR10317. 1 hit.
Pfami PF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view ]
PIRSFi PIRSF016255. eIF3e_su6. 1 hit.
SMARTi SM00088. PINT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiEIF3E_CAEEL
AccessioniPrimary (citable) accession number: O61820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3