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O61820

- EIF3E_CAEEL

UniProt

O61820 - EIF3E_CAEEL

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Protein
Eukaryotic translation initiation factor 3 subunit E
Gene
eif-3.E, B0511.10
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome By similarity.UniRule annotation

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
  2. regulation of translational initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit E
Short name:
eIF3e
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6
Gene namesi
Name:eif-3.E
ORF Names:B0511.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiB0511.10; CE17349; WBGene00001228; eif-3.E.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
  2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Eukaryotic translation initiation factor 3 subunit EUniRule annotation
PRO_0000123518Add
BLAST

Proteomic databases

PaxDbiO61820.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex By similarity.

Protein-protein interaction databases

BioGridi38371. 1 interaction.
IntActiO61820. 2 interactions.
STRINGi6239.B0511.10.

Structurei

3D structure databases

ProteinModelPortaliO61820.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini288 – 394107PCI
Add
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit E family.
Contains 1 PCI domain.

Phylogenomic databases

eggNOGiNOG324642.
GeneTreeiENSGT00390000002661.
HOGENOMiHOG000036697.
InParanoidiO61820.
KOiK03250.
OMAiDILTGKW.
PhylomeDBiO61820.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03004. eIF3e.
InterProiIPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10317. PTHR10317. 1 hit.
PfamiPF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
PIRSFiPIRSF016255. eIF3e_su6. 1 hit.
SMARTiSM00088. PINT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O61820-1 [UniParc]FASTAAdd to Basket

« Hide

MSTFDLTQRM APFLDLHLII PLLEFIEPRG IYDEKSLTEM HRQLLTKTNM    50
IDSVIETYNG KPIPAAIEAK KKQIIKERDE LKSKVDSVVA ILEIPEVKEM 100
MDNNRERDGN VRILEHLTQN HNFTVDMVDT LFKYSKFMYE CGNYTVASVC 150
LYYYRNLVNQ ADPNYLNALY GKLASEILLQ EWEHARDDLL KLRAYIDANP 200
FDTEWELVTQ RAWLMHWALF VYYNYPKGRD EIIEMFLNQQ PYLNAIQVLA 250
PHLLRYLAVA VVTSKSRQKN SLKDLVKVID IERHSYKDPV TDFLTCLYIK 300
YDFDEAQEML QKCEEVLSND FFLTAVLGDF RESARLLIFE MFCRIHQCIT 350
IEMLARRLNM SQEEAERWIV DLIRTYRIEG AKIDSKLGQV VMGVKSVSIH 400
EQVMENTKRL TLRAQQIALQ LEKGRQDKVK AT 432
Length:432
Mass (Da):50,720
Last modified:August 1, 1998 - v1
Checksum:i5489E810F201633F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080219 Genomic DNA. Translation: CCD62105.1.
PIRiT33118.
RefSeqiNP_492785.1. NM_060384.6.
UniGeneiCel.22775.

Genome annotation databases

EnsemblMetazoaiB0511.10; B0511.10; WBGene00001228.
GeneIDi172959.
KEGGicel:CELE_B0511.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080219 Genomic DNA. Translation: CCD62105.1 .
PIRi T33118.
RefSeqi NP_492785.1. NM_060384.6.
UniGenei Cel.22775.

3D structure databases

ProteinModelPortali O61820.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 38371. 1 interaction.
IntActi O61820. 2 interactions.
STRINGi 6239.B0511.10.

Proteomic databases

PaxDbi O61820.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0511.10 ; B0511.10 ; WBGene00001228 .
GeneIDi 172959.
KEGGi cel:CELE_B0511.10.

Organism-specific databases

CTDi 172959.
WormBasei B0511.10 ; CE17349 ; WBGene00001228 ; eif-3.E.

Phylogenomic databases

eggNOGi NOG324642.
GeneTreei ENSGT00390000002661.
HOGENOMi HOG000036697.
InParanoidi O61820.
KOi K03250.
OMAi DILTGKW.
PhylomeDBi O61820.

Miscellaneous databases

NextBioi 877691.
PROi O61820.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_03004. eIF3e.
InterProi IPR016650. eIF3e.
IPR019010. eIF3e_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10317. PTHR10317. 1 hit.
Pfami PF09440. eIF3_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view ]
PIRSFi PIRSF016255. eIF3e_su6. 1 hit.
SMARTi SM00088. PINT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiEIF3E_CAEEL
AccessioniPrimary (citable) accession number: O61820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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