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Protein
Submitted name:

Proteasome Regulatory Particle, Non-ATPase-like

Gene

rpn-8

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-195253. Degradation of beta-catenin by the destruction complex.
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4608870. Asymmetric localization of PCP proteins.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-6798695. Neutrophil degranulation.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiM67.973.

Names & Taxonomyi

Protein namesi
Submitted name:
Proteasome Regulatory Particle, Non-ATPase-likeImported
Gene namesi
Name:rpn-8Imported
ORF Names:CELE_R12E2.3Imported, R12E2.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiR12E2.3; CE18135; WBGene00004464; rpn-8.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

ProteasomeImported

PTM / Processingi

Proteomic databases

EPDiO61792.
PaxDbiO61792.
PeptideAtlasiO61792.

Expressioni

Gene expression databases

BgeeiWBGene00004464.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiO61792. 3 interactors.
MINTiMINT-210994.
STRINGi6239.R12E2.3.2.

Structurei

3D structure databases

ProteinModelPortaliO61792.
SMRiO61792.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 176MPN (JAB/Mov34)InterPro annotationAdd BLAST137

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili313 – 350Sequence analysisAdd BLAST38

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1556. Eukaryota.
COG1310. LUCA.
GeneTreeiENSGT00530000063075.
HOGENOMiHOG000209236.
InParanoidiO61792.
KOiK03038.
OMAiDAYFAVE.
OrthoDBiEOG091G0DX6.
PhylomeDBiO61792.

Family and domain databases

CDDicd08062. MPN_RPN7_8. 1 hit.
InterProiView protein in InterPro
IPR000555. JAMM/MPN+_dom.
IPR033858. MPN_RPN7_8.
IPR024969. Rpn11/EIF3F_C.
PANTHERiPTHR10540:SF13. PTHR10540:SF13. 1 hit.
PfamiView protein in Pfam
PF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
SMARTiView protein in SMART
SM00232. JAB_MPN. 1 hit.

Sequencei

Sequence statusi: Complete.

O61792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTNKDGDV ATVKAVDVLK QKAGAHHCLG NVHANLPVNK VTVHPLVLLS
60 70 80 90 100
VVDHFNRVSK TQSVKRVVGV LLGSMKKDKT LDIGNSFAVP FDEDDKDKST
110 120 130 140 150
WFLDMDYLES MYGMFYKVAA KEKIVGWYHT GPKLHKNDIA INEQLKRFCP
160 170 180 190 200
NPVLVIIDAE PKNIGLPTEA YIEVQEVHDD GTPPIKTFEH VPSDIGAEEA
210 220 230 240 250
EEVGVEHLLR DIKDQTAGTL SQRITDQLMG LRGLQSQLES IEKYLHDIVR
260 270 280 290 300
GTLPVNHHVI YYVQEVLNLL PDVTHPDYIV SQNVQTNDQL MCVYMGSLVR
310 320 330 340 350
SVVALHNLID NKISLQKAEK EQETGEAEKK KDEKDKKDKK DEKKDEKKEK
360
DSKSSTPNTP KK
Length:362
Mass (Da):40,687
Last modified:August 1, 1998 - v1
Checksum:i5ABA83CD1CF85373
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CCD65169.1.
PIRiT33096.
RefSeqiNP_491319.1. NM_058918.5.
UniGeneiCel.5686.

Genome annotation databases

EnsemblMetazoaiR12E2.3; R12E2.3; WBGene00004464.
GeneIDi172009.
KEGGicel:CELE_R12E2.3.
UCSCiR12E2.3.1. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiO61792_CAEEL
AccessioniPrimary (citable) accession number: O61792
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: June 7, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported