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Protein

Innexin-17

Gene

inx-17

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Structural component of the gap junctions.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Innexin-17
Alternative name(s):
Gap junction innexin
Protein opu-17
Gene namesi
Name:inx-17Imported
Synonyms:opu-17
ORF Names:R12E2.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiR12E2.4a; CE18136; WBGene00002139; inx-17.
R12E2.4b; CE38537; WBGene00002139; inx-17.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei101 – 121HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei189 – 209HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei266 – 286HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002085161 – 362Innexin-17Add BLAST362

Proteomic databases

EPDiO61788.
PaxDbiO61788.
PeptideAtlasiO61788.
PRIDEiO61788.

Expressioni

Gene expression databases

BgeeiWBGene00002139.

Interactioni

Protein-protein interaction databases

STRINGi6239.R12E2.4a.2.

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JBYK. Eukaryota.
ENOG41117UU. LUCA.
GeneTreeiENSGT00530000064205.
HOGENOMiHOG000017412.
InParanoidiO61788.
KOiK22037.
OMAiWFVLMRV.
OrthoDBiEOG091G086D.
PhylomeDBiO61788.

Family and domain databases

InterProiView protein in InterPro
IPR000990. Innexin.
PANTHERiPTHR11893. PTHR11893. 1 hit.
PfamiView protein in Pfam
PF00876. Innexin. 1 hit.
PRINTSiPR01262. INNEXIN.
PROSITEiView protein in PROSITE
PS51013. PANNEXIN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: O61788-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIDTGFYSK TITPTYDSDA IDRLRYYFTV FLLTSSAFFI MAKQYVGQSI
60 70 80 90 100
QCWAPKQFKG GWEEYAESYC LIENTYYVHM NNSNLPGPAI RENKELKYYQ
110 120 130 140 150
WVPFILFGLA VVIYIPRVIW NALQSLIGIN ISIVTSNLRK VAKSGFTSEN
160 170 180 190 200
PDIEKKKKEM QCKKKATSRQ VDGEFWGSRL TTCILATKFL ATILIFISMG
210 220 230 240 250
FLDYFMGLGP MYGWTITKDI LQGRQWQESG SFPRVTFCDF QVRELGYVNN
260 270 280 290 300
WSLQCVLMVN MFNEKLFIAL WWWYALLAIL SIFDIFRVLF RFTIHHQISF
310 320 330 340 350
ITRILACTGD SAISATEVGE FNRKVLRIDG INLTHLVYAN ATIFEAADFV
360
RPMWEQFKEN QN
Note: No experimental confirmation available.Curated
Length:362
Mass (Da):42,100
Last modified:August 1, 1998 - v1
Checksum:i8A3360F299AA4398
GO
Isoform b (identifier: O61788-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     261-266: MFNEKL → IRNFNS
     267-362: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:266
Mass (Da):30,820
Checksum:i3C19A69A5C34B446
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016615261 – 266MFNEKL → IRNFNS in isoform b. Curated6
Alternative sequenceiVSP_016616267 – 362Missing in isoform b. CuratedAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080613 Genomic DNA. Translation: CCD65170.1.
FO080613 Genomic DNA. Translation: CCD65171.1.
AF303262 mRNA. Translation: AAG50220.1.
PIRiT33092.
RefSeqiNP_001021592.1. NM_001026421.1. [O61788-2]
NP_491315.1. NM_058914.3. [O61788-1]
UniGeneiCel.19417.

Genome annotation databases

EnsemblMetazoaiR12E2.4a; R12E2.4a; WBGene00002139. [O61788-1]
GeneIDi172006.
KEGGicel:CELE_R12E2.4.
UCSCiR12E2.4b. c. elegans. [O61788-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiINX17_CAEEL
AccessioniPrimary (citable) accession number: O61788
Secondary accession number(s): Q2Z1N8, Q86S32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families