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Protein

Innexin-17

Gene

inx-17

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Structural components of the gap junctions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Innexin-17
Alternative name(s):
Gap junction innexin
Protein opu-17
Gene namesi
Name:inx-17Imported
Synonyms:opu-17
ORF Names:R12E2.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiR12E2.4a; CE18136; WBGene00002139; inx-17.
R12E2.4b; CE38537; WBGene00002139; inx-17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei101 – 12121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei189 – 20921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei266 – 28621HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Innexin-17PRO_0000208516Add
BLAST

Proteomic databases

EPDiO61788.
PaxDbiO61788.
PRIDEiO61788.

Interactioni

Protein-protein interaction databases

STRINGi6239.R12E2.4a.2.

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JBYK. Eukaryota.
ENOG41117UU. LUCA.
GeneTreeiENSGT00530000064205.
HOGENOMiHOG000017412.
InParanoidiO61788.
OMAiSIQCWAP.
PhylomeDBiO61788.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PANTHERiPTHR11893. PTHR11893. 1 hit.
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PRINTSiPR01262. INNEXIN.
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: O61788-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIDTGFYSK TITPTYDSDA IDRLRYYFTV FLLTSSAFFI MAKQYVGQSI
60 70 80 90 100
QCWAPKQFKG GWEEYAESYC LIENTYYVHM NNSNLPGPAI RENKELKYYQ
110 120 130 140 150
WVPFILFGLA VVIYIPRVIW NALQSLIGIN ISIVTSNLRK VAKSGFTSEN
160 170 180 190 200
PDIEKKKKEM QCKKKATSRQ VDGEFWGSRL TTCILATKFL ATILIFISMG
210 220 230 240 250
FLDYFMGLGP MYGWTITKDI LQGRQWQESG SFPRVTFCDF QVRELGYVNN
260 270 280 290 300
WSLQCVLMVN MFNEKLFIAL WWWYALLAIL SIFDIFRVLF RFTIHHQISF
310 320 330 340 350
ITRILACTGD SAISATEVGE FNRKVLRIDG INLTHLVYAN ATIFEAADFV
360
RPMWEQFKEN QN
Note: No experimental confirmation available.Curated
Length:362
Mass (Da):42,100
Last modified:August 1, 1998 - v1
Checksum:i8A3360F299AA4398
GO
Isoform b (identifier: O61788-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     261-266: MFNEKL → IRNFNS
     267-362: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:266
Mass (Da):30,820
Checksum:i3C19A69A5C34B446
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei261 – 2666MFNEKL → IRNFNS in isoform b. CuratedVSP_016615
Alternative sequencei267 – 36296Missing in isoform b. CuratedVSP_016616Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080613 Genomic DNA. Translation: CCD65170.1.
FO080613 Genomic DNA. Translation: CCD65171.1.
AF303262 mRNA. Translation: AAG50220.1.
PIRiT33092.
RefSeqiNP_001021592.1. NM_001026421.1. [O61788-2]
NP_491315.1. NM_058914.3. [O61788-1]
UniGeneiCel.19417.

Genome annotation databases

EnsemblMetazoaiR12E2.4a; R12E2.4a; WBGene00002139. [O61788-1]
GeneIDi172006.
KEGGicel:CELE_R12E2.4.
UCSCiR12E2.4b. c. elegans. [O61788-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080613 Genomic DNA. Translation: CCD65170.1.
FO080613 Genomic DNA. Translation: CCD65171.1.
AF303262 mRNA. Translation: AAG50220.1.
PIRiT33092.
RefSeqiNP_001021592.1. NM_001026421.1. [O61788-2]
NP_491315.1. NM_058914.3. [O61788-1]
UniGeneiCel.19417.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.R12E2.4a.2.

Proteomic databases

EPDiO61788.
PaxDbiO61788.
PRIDEiO61788.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR12E2.4a; R12E2.4a; WBGene00002139. [O61788-1]
GeneIDi172006.
KEGGicel:CELE_R12E2.4.
UCSCiR12E2.4b. c. elegans. [O61788-1]

Organism-specific databases

CTDi172006.
WormBaseiR12E2.4a; CE18136; WBGene00002139; inx-17.
R12E2.4b; CE38537; WBGene00002139; inx-17.

Phylogenomic databases

eggNOGiENOG410JBYK. Eukaryota.
ENOG41117UU. LUCA.
GeneTreeiENSGT00530000064205.
HOGENOMiHOG000017412.
InParanoidiO61788.
OMAiSIQCWAP.
PhylomeDBiO61788.

Miscellaneous databases

PROiO61788.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PANTHERiPTHR11893. PTHR11893. 1 hit.
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PRINTSiPR01262. INNEXIN.
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "The Caenorhabditis elegans transcriptome project, a complementary view of the genome."
    Kohara Y., Shin-i T., Suzuki Y., Sugano S., Potdevin M., Thierry-Mieg Y., Thierry-Mieg D., Thierry-Mieg J.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: Bristol N2.

Entry informationi

Entry nameiINX17_CAEEL
AccessioniPrimary (citable) accession number: O61788
Secondary accession number(s): Q2Z1N8, Q86S32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.