Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Innexin-19

Gene

inx-19

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Structural component of the gap junctions that specifically coordinates left-right asymmetry in the developing nervous system. Acts by forming gap junction network linking embryonic neurons and providing electrical coupling between cells, leading to promote or inhibit AWC signaling. Required for the left and right AWC olfactory neurons to establish asymmetric patterns of gene expression during embryogenesis. Acts autonomously.1 Publication

GO - Molecular functioni

  • calcium channel inhibitor activity Source: WormBase
  • gap junction channel activity Source: UniProtKB
  • gap junction hemi-channel activity Source: UniProtKB
  • protein kinase inhibitor activity Source: WormBase

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • determination of left/right asymmetry in nervous system Source: WormBase
  • inactivation of MAPKKK activity Source: WormBase
  • intercellular transport Source: WormBase
  • ion transport Source: UniProtKB-KW
  • negative regulation of cation channel activity Source: WormBase
  • negative regulation of protein kinase activity Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ion channel

Keywords - Biological processi

Differentiation, Ion transport, Neurogenesis, Transport

Protein family/group databases

TCDBi1.A.25.1.5. the gap junction-forming innexin (innexin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Innexin-19
Alternative name(s):
Neuronal symmetry protein 5
Protein opu-19
Gene namesi
Name:inx-19
Synonyms:nsy-5, opu-19
ORF Names:T16H5.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiT16H5.1a; CE30834; WBGene00002141; inx-19.
T16H5.1b; CE33183; WBGene00002141; inx-19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48CytoplasmicSequence analysisAdd BLAST48
Transmembranei49 – 69HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini70 – 118ExtracellularSequence analysisAdd BLAST49
Transmembranei119 – 139HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini140 – 214CytoplasmicSequence analysisAdd BLAST75
Transmembranei215 – 235HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini236 – 300ExtracellularSequence analysisAdd BLAST65
Transmembranei301 – 321HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini322 – 454CytoplasmicSequence analysisAdd BLAST133

GO - Cellular componenti

  • gap junction Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body membrane Source: WormBase
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi70E → K in ky634; absence of chemotaxis to the odorant 2-butanone, which is sensed by AWC(ON), but normal response to the odorant 2,3-pentanedione, which is sensed by AWC(OFF), suggesting the absence of functional AWC(ON) neurons. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003413721 – 454Innexin-19Add BLAST454

Proteomic databases

PaxDbiO61715.

Expressioni

Tissue specificityi

Specifically expressed in sensory neurons and interneurons in the head and tail. Expressed in neurons AWC, ASH, AFD, ASI, ADL, ASK, BAG, AWB, and ADF (head sensory neurons); ADA, AIZ, RIC, AIY, and AIM (head interneurons); PHA and PHB (tail sensory neurons); and PVC and PVQ (tail interneurons).1 Publication

Developmental stagei

Expression begins about halfway through embryogenesis. Expressed at higher level in late embryos and in L1 larvae, and fades thereafter. In adults, a weak expression is maintained in several neurons, including ASH but not AWC.1 Publication

Gene expression databases

BgeeiWBGene00002141.

Interactioni

Protein-protein interaction databases

STRINGi6239.T16H5.1a.

Structurei

3D structure databases

ProteinModelPortaliO61715.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II24. Eukaryota.
ENOG410Y2UW. LUCA.
GeneTreeiENSGT00530000064205.
HOGENOMiHOG000017412.
InParanoidiO61715.
OMAiLANLNRY.
OrthoDBiEOG091G076W.
PhylomeDBiO61715.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PANTHERiPTHR11893. PTHR11893. 1 hit.
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PRINTSiPR01262. INNEXIN.
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: O61715-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRTPASTGP LRQDRQMFFH ATLARSFINA LSVRGDDDAV DRLNYYYTPL
60 70 80 90 100
ILAVCCLVIS AKQYGGTPIE CWVNPHSRES MEEYIESYCW IQNTYWIPMY
110 120 130 140 150
ENVPDDHTAR EEKQIGYYQW VPFILIAEAL MFSLPCIFWR LCSFQSGLNI
160 170 180 190 200
QTLINAACDG QALLDASDRQ KAVEAITTNF VDNLDLQSPN GRIRARGWIA
210 220 230 240 250
RIKFSRFLSG QCLSILHSFT KLLYSMNVVA QFLILNACLK SSDFLFFGFQ
260 270 280 290 300
VLNDIWAGRP WTETGHFPRV TLCDFEVRYL ANLNRYTVQC ALLINIINEK
310 320 330 340 350
VFAFLWCWYM ILAIITTCSF IYWIANSFIH SEKVDYVMKF IQIAESSEFK
360 370 380 390 400
KLQKFEKDAT VERLYTVIAF APHLLDTFVS DFLKSDGVLM LRMISNHAGD
410 420 430 440 450
MIVVQLVRNL WQEFRERNWR EFEEHEEMKD VEMRRIHGGE RIVISNPGQT

KSFL
Length:454
Mass (Da):52,975
Last modified:October 1, 2002 - v2
Checksum:iE408BE61913358F2
GO
Isoform b (identifier: O61715-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:438
Mass (Da):51,093
Checksum:iB588487095E40A4B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0342671 – 16Missing in isoform b. CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081208 Genomic DNA. Translation: CCD69899.1.
FO081208 Genomic DNA. Translation: CCD69900.1.
RefSeqiNP_490983.2. NM_058582.5. [O61715-1]
NP_871864.1. NM_182064.3. [O61715-2]
UniGeneiCel.6136.

Genome annotation databases

EnsemblMetazoaiT16H5.1a; T16H5.1a; WBGene00002141. [O61715-1]
GeneIDi171805.
KEGGicel:CELE_T16H5.1.
UCSCiT16H5.1a. c. elegans. [O61715-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081208 Genomic DNA. Translation: CCD69899.1.
FO081208 Genomic DNA. Translation: CCD69900.1.
RefSeqiNP_490983.2. NM_058582.5. [O61715-1]
NP_871864.1. NM_182064.3. [O61715-2]
UniGeneiCel.6136.

3D structure databases

ProteinModelPortaliO61715.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T16H5.1a.

Protein family/group databases

TCDBi1.A.25.1.5. the gap junction-forming innexin (innexin) family.

Proteomic databases

PaxDbiO61715.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT16H5.1a; T16H5.1a; WBGene00002141. [O61715-1]
GeneIDi171805.
KEGGicel:CELE_T16H5.1.
UCSCiT16H5.1a. c. elegans. [O61715-1]

Organism-specific databases

CTDi171805.
WormBaseiT16H5.1a; CE30834; WBGene00002141; inx-19.
T16H5.1b; CE33183; WBGene00002141; inx-19.

Phylogenomic databases

eggNOGiENOG410II24. Eukaryota.
ENOG410Y2UW. LUCA.
GeneTreeiENSGT00530000064205.
HOGENOMiHOG000017412.
InParanoidiO61715.
OMAiLANLNRY.
OrthoDBiEOG091G076W.
PhylomeDBiO61715.

Miscellaneous databases

PROiO61715.

Gene expression databases

BgeeiWBGene00002141.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PANTHERiPTHR11893. PTHR11893. 1 hit.
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PRINTSiPR01262. INNEXIN.
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINX19_CAEEL
AccessioniPrimary (citable) accession number: O61715
Secondary accession number(s): Q86S34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.